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Note 6 - Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2018

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended March 31,
		2018				2017
Research and development			16,372				43,322
General and administrative			308,295				323,061
Total stock-based compensation expense			324,667				366,383

Share-based Compensation, Stock Options, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)
Balance at January 1, 2018			2,555,989				7.32
Granted			500,000				1.18
Expired			(2,192	)			17.10
Outstanding at March 31, 2018			3,053,797				6.30				7.36
Exercisable at March 31, 2018			2,011,881				7.84				6.46

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Expected term (in years)			5.66
Risk-free interest rate			2.3	%
Expected volatility			112.7	%
Dividend yield			—	%

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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