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Note 5 - Convertible Preferred Stock, Common Stock and Common Stock Warrants - Warrants Outstanding to Acquire Shares of Its Common Stock (Details) - $ / shares	Mar. 31, 2018	Jan. 31, 2018	Jan. 22, 2018
Common stock warrants, outstanding (in shares)	31,707,233
Warrants issued before 2016 [Member]
Common stock warrants, outstanding (in shares)	430,721
Warrants issued before 2016 [Member] | Minimum [Member]
Range of exercise price (in dollars per share)	$ 20
Warrants issued before 2016 [Member] | Maximum [Member]
Range of exercise price (in dollars per share)	$ 49
Series A Convertible Preferred Stock [Member]
Common stock warrants, outstanding (in shares)	13,555,887
Range of exercise price (in dollars per share)	$ 2.22
Warrants Issued in Connection with the January 2018 Offering [Member]
Common stock warrants, outstanding (in shares)	17,720,625
Range of exercise price (in dollars per share)		$ 0.80	$ 0.80
Warrants Issued in Connection with the January 2018 Offering [Member] | Minimum [Member]
Range of exercise price (in dollars per share)	$ 0.80
Warrants Issued in Connection with the January 2018 Offering [Member] | Maximum [Member]
Range of exercise price (in dollars per share)	$ 1

X

- Definition

Exercise price per share or per unit of warrants or rights outstanding.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(4))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	num:perShareItemType
Balance Type:	na
Period Type:	instant

X

- Definition

Number of warrants or rights outstanding.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

+ Details

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X

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X

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X

- Details

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- Details

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