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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended
September 30,
   
Nine Months Ended
September 30,
 
   
2018
   
2017
   
2018
   
2017
 
Basic net (loss) income per common share calculation:
                               
Net (loss) income
  $
(6,719,730
)
  $
5,096,856
    $
(12,798,872
)
  $
(3,154,181
)
Accretion of Series A cumulative preferred dividends
   
     
(366,641
)
   
(85,993
)
   
(912,946
)
Undistributed earnings allocated to participating securities
   
     
(1,838,354
)
   
 
     
 
 
Deemed dividend related to the make-whole provision for the conversion of Series A preferred stock into common
   
     
     
(8,167,895
)
   
 
Net (loss) income attributable to common
   
(6,719,730
)
   
2,891,861
     
(21,052,760
)
   
(4,067,127
)
                                 
Weighted average common shares outstanding, basic
   
50,572,001
     
13,937,869
     
47,777,757
     
11,709,128
 
Net (loss) income per share of common, basic
  $
(0.13
)
  $
0.21
    $
(0.44
)
  $
(0.35
)
                                 
Diluted net income (loss) per common share calculation:
                               
Net income (loss) attributable to common
   
(6,719,730
)
   
2,891,861
     
(21,052,760
)
   
(4,067,127
)
Change in fair value of warrant liability
   
     
     
     
(18,909,792
)
Interest on convertible debt
   
     
28,891
     
     
 
Diluted net loss
   
(6,719,730
)
   
2,920,752
     
(21,052,760
)
   
(22,976,919
)
Weighted average common shares outstanding, basic
   
50,572,001
     
13,937,869
     
47,777,757
     
11,709,128
 
Common stock equivalents arising from stock options
   
     
20,608
     
     
 
Common stock equivalents arising from warrants
   
     
     
     
816,579
 
Common stock equivalents arising from convertible debt
   
     
756,376
     
     
 
Common stock equivalents
   
50,572,001
     
14,714,853
     
47,777,757
     
12,525,707
 
Diluted net loss per share of common
  $
(0.13
)
  $
0.20
    $
(0.44
)
  $
(1.83
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended
September 30,
   
Nine Months Ended
September 30,
 
   
2018
   
2017
   
2018
   
2017
 
Convertible debt
   
     
     
     
213,879
 
Common stock warrants
   
31,303,012
     
14,003,608
     
31,303,012
     
447,721
 
Stock options
   
3,213,797
     
2,521,605
     
3,213,797
     
2,545,989
 
Unvested restricted stock awards
   
     
4,599
     
     
4,599
 
     
34,516,809
     
16,529,812
     
34,516,809
     
3,212,188