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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies - Outstanding Dilutive Securities (Details) - shares
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Anti-dilutive securities (in shares) 34,516,809 16,529,812 34,516,809 3,212,188
Convertible Debt Securities [Member]        
Anti-dilutive securities (in shares) 213,879
Warrant [Member]        
Anti-dilutive securities (in shares) 31,303,012 14,003,608 31,303,012 447,721
Employee Stock Option [Member]        
Anti-dilutive securities (in shares) 3,213,797 2,521,605 3,213,797 2,545,989
Restricted Stock [Member]        
Anti-dilutive securities (in shares) 4,599 4,599