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Note 7 - Stock-based Compensation - Stock Option Activity (Details)
 9 Months Ended
Sep. 30, 2018
$ / shares
shares
Options outstanding, number (in shares) | shares 2,555,989
Options outstanding, weighted-average exercise price (in dollars per share) | $ / shares $ 7.32
Granted (in shares) | shares 660,000
Granted, weighted-average exercise price (in dollars per share) | $ / shares $ 1.02
Expired (in shares) | shares (2,192)
Expired, weighted-average exercise price (in dollars per share) | $ / shares $ 17.10
Options outstanding, number (in shares) | shares 3,213,797
Options outstanding, weighted-average exercise price (in dollars per share) | $ / shares $ 6.02
Options outstanding, weighted-average remaining contractual life (Year) 7 years 3 days
Exercisable (in shares) | shares 2,361,007
Exercisable, weighted-average exercise price (in dollars per share) | $ / shares $ 7.09
Exercisable, weighted-average remaining contractual life (Year) 6 years 127 days