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Note 12 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Net operating loss carryforwards | $ 5,875,074 | $ 5,310,628
Stock option compensation | 2,456,410 | 2,141,973
Orphan Drug credits | 2,847,803 | 2,537,039
Capitalized start-up costs and other | 7,349,092 | 5,247,468
Valuation allowance | (18,091,090) | (15,237,108)
Net deferred tax asset | 437,289 |
Intangible assets | (2,223,678) | (2,223,678)
Net deferred tax liability | $ (1,786,389) | $ (2,223,678)

X
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- Definition Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (b),(c) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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