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Note 9 - Convertible Preferred Stock, Stockholders' Equity and Common Stock Warrants - Warrants Outstanding to Acquire Shares of Its Common Stock (Details) - $ / shares | Dec. 31, 2018 | Jan. 31, 2018 | Jan. 22, 2018
--- | --- | --- | ---
Common stock warrants, outstanding (in shares) | 2,087,012 |  |
Warrants issued before 2016 [Member] |  |  |
Common stock warrants, outstanding (in shares) | 1,767 |  |
Warrants issued before 2016 [Member] | Minimum [Member] |  |  |
Range of exercise price (in dollars per share) | $ 562.50 |  |
Warrants issued before 2016 [Member] | Maximum [Member] |  |  |
Range of exercise price (in dollars per share) | $ 735 |  |
Warrants Attached to Series A Convertible Preferred Stock [Member] |  |  |
Common stock warrants, outstanding (in shares) | 903,870 |  |
Range of exercise price (in dollars per share) | $ 33.30 |  |
Warrants Issued in Connection with the January 2018 Offering [Member] |  |  |
Common stock warrants, outstanding (in shares) | 1,181,375 |  |
Range of exercise price (in dollars per share) |  | $ 12 | $ 12
Warrants Issued in Connection with the January 2018 Offering [Member] | Minimum [Member] |  |  |
Range of exercise price (in dollars per share) | $ 12 |  |
Warrants Issued in Connection with the January 2018 Offering [Member] | Maximum [Member] |  |  |
Range of exercise price (in dollars per share) | $ 15 |  |

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