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Note 9 - Convertible Preferred Stock, Stockholders' Equity and Common Stock Warrants (Details Textual) - USD ($) |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jan. 22, 2018 | Jan. 31, 2018 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Mar. 13, 2017
Stock Issued During Period, Shares, Issued for Services |  |  |  | 7,792 | 1,174 |
Stock Issued During Period, Shares, Conversion of Convertible Securities |  | 553,752 |  |  |  |
Common Stock Dividends, Shares |  | 68,815 |  |  |  |
Stock Issued During Period, Shares, Make-whole Adjustment |  | 777,895 |  |  |  |
Dividends, Make-whole Adjustment |  | $ 8,200,000 |  | $ 8,167,895 |  |
Proceeds from Issuance of Convertible Preferred Stock, Net of Offering Costs |  |  |  |  | 22,129,774 |
Warrant Expense |  |  |  |  | $ 10,225,846 |
Stock Repurchased and Retired During Period, Shares |  |  |  | 0 | 0 |
Class of Warrant or Rights, Expired |  |  |  | 28,123 | 867 |
Series A Preferred Stock [Member] |  |  |  |  |  |
Proceeds from Issuance of Private Placement |  |  |  |  | $ 0 |
Preferred Stock, Shares Authorized |  |  |  | 0 |  | 13,750,000
Preferred Stock, Shares Issued, Total |  |  |  | 0 |  |
Preferred Stock, Shares Outstanding, Ending Balance |  |  |  | 0 |  |
Conversion From Series A Preferred Stock to Common Stock [Member] |  |  |  |  |  |
Conversion of Stock, Shares Issued | 1,400,462 | 1,400,462 |  |  |  |
Warrants Issued in Connection with the January 2018 Offering [Member] |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 1,000,000 | 1,000,000 |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ 12 | $ 12 |  |  |  |
Class of Warrant or Right, Term | 5 years |  |  |  |  |
Warrants Issued in Connection with the January 2018 Offering [Member] | Maximum [Member] |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  | $ 15 |  |
Option Warrants [Member] |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  | 150,000 |  |  |  |
Additional Warrants [Member] |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  | $ 12 |  |  |  |
Class of Warrant or Right, Granted |  | 131,375 |  |  |  |
Underwriter Warrants [Member] |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ 15 | $ 15 |  |  |  |
Class of Warrant or Right, Term | 5 years | 5 years |  |  |  |
Underwriter Warrants [Member] | Maximum [Member] |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 50,000 | 50,000 |  |  |  |
January 2018 Offering [Member] |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues | 1,000,000 | 1,000,000 |  |  |  |
Proceeds from Issuance or Sale of Equity, Total | $ 10,800,000 | $ 10,800,000 |  |  |  |
Stock Issued During Period, Shares, Issued for Services |  | 150,000 |  |  |  |
January 2018 Offering [Member] | Additional Warrants [Member] |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 131,375 |  |  |  |  |
Private Placement [Member] | Warrant [Member] |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  | $ 33.30 |  |  |
Class of Warrant or Right, Term |  |  | 5 years |  |  |
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right |  |  | 1 |  |  |
Warrant Expense |  |  |  |  | $ 10,200,000 |
Private Placement [Member] | Series A Preferred Stock [Member] |  |  |  |  |  |
Proceeds from Issuance of Private Placement |  |  | $ 25,000,000 |  |  |
Number of Convertible Preferred Stock Per Unit |  |  | 1 |  |  |
Preferred Stock, Dividend Rate, Percentage |  |  | 8.00% |  |  |
Number of Common Stock Per Unit |  |  | 1 |  |  |
Convertible Preferred Stock, Conversion Price |  |  | $ 30.30 |  |  |
Temporary Equity, Stock Issued During Period, New Issues |  |  | 12,376,329 |  |  |
Proceeds from Issuance of Convertible Preferred Stock, Net of Offering Costs |  |  | $ 22,100,000 |  |  |
Payments of Stock Issuance Costs |  |  | $ 2,900,000 |  |  |
Private Placement [Member] | Series B Preferred Stock [Member] | Placement Agent [Member] |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  | $ 33.30 |  |  |
Class of Warrant or Right, Term |  |  | 5 years |  |  |
Class of Warrant or Right, Granted During Period |  |  | 78,637 |  |  |

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