    <SEC-DOCUMENT>0001437749-19-010251-index.html : 20190516
    <SEC-HEADER>0001437749-19-010251.hdr.sgml : 20190516
    <ACCEPTANCE-DATETIME>20190516163643
    ACCESSION NUMBER:		0001437749-19-010251
    CONFORMED SUBMISSION TYPE:	S-3
    PUBLIC DOCUMENT COUNT:		13
    FILED AS OF DATE:		20190516
    DATE AS OF CHANGE:		20190516

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-231541
    		FILM NUMBER:		19832812

    	BUSINESS ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-3
    <SEQUENCE>1
    <FILENAME>dffn20190514_s3.htm
    <DESCRIPTION>FORM S-3
    <TEXT>
    Document 1 - file: dffn20190514_s3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.1
    <SEQUENCE>2
    <FILENAME>ex_145198.htm
    <DESCRIPTION>EXHIBIT 4.1
    <TEXT>
    Document 2 - file: ex_145198.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.3
    <SEQUENCE>3
    <FILENAME>ex_144952.htm
    <DESCRIPTION>EXHIBIT 4.3
    <TEXT>
    Document 3 - file: ex_144952.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>4
    <FILENAME>ex_144951.htm
    <DESCRIPTION>EXHIBIT 5.1
    <TEXT>
    Document 4 - file: ex_144951.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>5
    <FILENAME>ex_145199.htm
    <DESCRIPTION>EXHIBIT 23.1
    <TEXT>
    Document 5 - file: ex_145199.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>a1.jpg
    <TEXT>
    Document 6 - file: a1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>a2.jpg
    <TEXT>
    Document 7 - file: a2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>dffn20190514_s3img003.gif
    <TEXT>
    Document 8 - file: dffn20190514_s3img003.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>dffn20190514_s3img004.gif
    <TEXT>
    Document 9 - file: dffn20190514_s3img004.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>ex01.jpg
    <TEXT>
    Document 10 - file: ex01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>ex02.jpg
    <TEXT>
    Document 11 - file: ex02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>logox.jpg
    <TEXT>
    Document 12 - file: logox.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>s3img002.jpg
    <TEXT>
    Document 13 - file: s3img002.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>