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Note 8 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2019
Notes Tables |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year ended December 31, |
|  | 2019 |  |  | 2018 |
Research and development |  | $ | 54,155 |  |  | $ | 62,161 |
General and administrative |  |  | 461,607 |  |  |  | 1,159,430 |
Total stock-based compensation expense |  | $ | 515,762 |  |  | $ | 1,221,591 |
Share-based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate Intrinsic Value |
Balance at January 1, 2018 |  |  | 170,461 |  |  | $ | 109.74 |  |  |  |  |  |  |  |  |
Granted |  |  | 44,005 |  |  |  | 15.37 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (10,583 | ) |  |  | 131.25 |  |  |  |  |  |  |  |  |
Expired |  |  | (147 | ) |  |  | 256.50 |  |  |  |  |  |  |  |  |
Balance at January 1, 2019 |  |  | 203,736 |  |  | $ | 88.14 |  |  |  | 6.70 |  |  | $ | 143 |
Granted |  |  | 117,270 |  |  |  | 2.62 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (11,583 | ) |  |  | 83.81 |  |  |  |  |  |  |  |  |
Expired |  |  | (147 | ) |  |  | 276.00 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2019 |  |  | 309,276 |  |  | $ | 55.78 |  |  |  | 6.98 |  |  | $ | — |
Exercisable at December 31, 2019 |  |  | 235,415 |  |  | $ | 71.75 |  |  |  | 6.34 |  |  | $ | — |
Vested and expected to vest at December 31, 2019 |  |  | 309,276 |  |  | $ | 55.78 |  |  |  | 6.98 |  |  | $ | — |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2019 |  |  | 2018 |
Expected term (in years) |  |  | 5.25 |  |  |  | — |  |  |  | 5.77 |  |  |  | 5.27 |  |  |  | — |  |  |  | 5.66 |
Risk-free interest rate |  |  | 1.9 | % |  |  | — |  |  |  | 2.5 | % |  |  | 2.3 | % |  |  | — |  |  |  | 2.8 | %
Expected volatility |  |  | 112.4 | % |  |  | — |  |  |  | 114.4 | % |  |  | 113.6 | % |  |  | — |  |  |  | 115.0 | %
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 + Details
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