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Note 8 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018
Stock-based compensation expense | $ 515,762 | $ 1,221,591
Research and Development Expense [Member] |  |
Stock-based compensation expense | 54,155 | 62,161
General and Administrative Expense [Member] |  |
Stock-based compensation expense | $ 461,607 | $ 1,159,430

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