    <SEC-DOCUMENT>0001437749-20-011311-index.html : 20200519
    <SEC-HEADER>0001437749-20-011311.hdr.sgml : 20200519
    <ACCEPTANCE-DATETIME>20200519172939
    ACCESSION NUMBER:		0001437749-20-011311
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		6
    FILED AS OF DATE:		20200519
    DATE AS OF CHANGE:		20200519

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-231541
    		FILM NUMBER:		20894842

    	BUSINESS ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>dffn20200518_424b5.htm
    <DESCRIPTION>FORM 424B5
    <TEXT>
    Document 1 - file: dffn20200518_424b5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>dffn20190514_s3img003.gif
    <TEXT>
    Document 2 - file: dffn20190514_s3img003.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>dffn20190514_s3img004.gif
    <TEXT>
    Document 3 - file: dffn20190514_s3img004.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>dffn20200518_424b5img001.jpg
    <TEXT>
    Document 4 - file: dffn20200518_424b5img001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>logo1.jpg
    <TEXT>
    Document 5 - file: logo1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>s3img002.jpg
    <TEXT>
    Document 6 - file: s3img002.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>