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Note 8 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2020
Notes Tables |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year ended December 31, |
|  | 2020 |  |  | 2019 |
Research and development |  | $ | 164,791 |  |  | $ | 54,155 |
General and administrative |  |  | 571,328 |  |  |  | 461,607 |
Total stock-based compensation expense |  | $ | 736,119 |  |  | $ | 515,762 |
Share-based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate Intrinsic Value |
Balance at January 1, 2019 |  |  | 203,736 |  |  | $ | 88.14 |  |  |  |  |  |  |  |  |
Granted |  |  | 117,270 |  |  |  | 2.62 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (11,583 | ) |  |  | 83.81 |  |  |  |  |  |  |  |  |
Expired |  |  | (147 | ) |  |  | 276.00 |  |  |  |  |  |  |  |  |
Balance at December 31, 2019 |  |  | 309,276 |  |  | $ | 55.78 |  |  |  | 6.98 |  |  |  | — |
Granted |  |  | 1,931,100 |  |  |  | 0.68 |  |  |  |  |  |  |  |  |
Expired |  |  | (172 | ) |  |  | 142.50 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2020 |  |  | 2,240,204 |  |  | $ | 8.28 |  |  |  | 8.90 |  |  | $ | 289,067 |
Exercisable at December 31, 2020 |  |  | 1,129,733 |  |  | $ | 15.64 |  |  |  | 8.28 |  |  | $ | 219,010 |
Vested and expected to vest at December 31, 2020 |  |  | 2,240,204 |  |  | $ | 8.28 |  |  |  | 8.90 |  |  | $ | 289,067 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2020 |  | 2019
Expected term (in years) |  | 5.31 | — | 10.00 |  | 5.25 | — | 5.77
Risk-free interest rate |  | 0.4% | — | 1.7% |  | 1.9% | — | 2.5%
Expected volatility |  | 113.4% | — | 124.8% |  | 112.4% | — | 114.4%
Dividend yield |  | — | — | — |  | — | — | —

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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