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Note 8 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019
Stock-based compensation expense | $ 736,119 | $ 515,762
Research and Development Expense [Member] |  |
Stock-based compensation expense | 164,791 | 54,155
General and Administrative Expense [Member] |  |
Stock-based compensation expense | $ 571,328 | $ 461,607

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