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Note 6 - Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2021

Notes Tables

Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Three Months Ended March 31,
		2021				2020
Research and development		$	33,000			$	96,530
General and administrative			148,280				94,850
Total stock-based compensation expense		$	181,280			$	191,380

Share-based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)				Aggregate intrinsic value
Balance at January 1, 2021			2,240,204			$	8.28
Granted			876,615				1.11
Outstanding at March 31, 2021			3,116,819			$	6.26				9.01			$	475,258
Exercisable at March 31, 2021			1,363,373			$	13.10				8.25			$	331,618
Vested and expected to vest at March 31, 2021			3,116,819			$	6.26				9.01			$	475,258

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Expected term (in years)			10
Risk-free interest rate			1.4	%
Expected volatility			124.6	%
Dividend yield			—

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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- Definition

Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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