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Note 8 - Income Taxes (Details Textual) | 12 Months Ended
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Dec. 31, 2021
Deferred Tax Assets, Valuation Allowance, Percentage | 100.00%
Open Tax Year | 2018

X
- Definition Deferred tax Assets' percentage related to net of valuation allowance. + References No definition available. + Details
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Namespace Prefix: | dffn_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tax year that remains open to examination under enacted tax laws, in YYYY format. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32718-109319 + Details
Name: | us-gaap_OpenTaxYear
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:gYearListItemType
Balance Type: | na
Period Type: | duration