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Note 6 - Stockholders' Equity and Common Stock Warrants (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Feb. 28, 2021 | May 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020
Proceeds from Issuance of Common Stock |  |  | $ 31,094,302 | $ 10,827,100
Deemed Dividend From Warrant Exchange |  | $ 2,000,000.0 | $ (0) | $ 1,950,378
Class of Warrant or Rights, Expired (in shares) |  |  | 53,570 | 0
Class of Warrant or Right, Exercised During Period (in shares) |  |  | 4,230,000 | 19,106,504
Proceeds from Warrant Exercises |  |  | $ 2,200,000 | $ 8,000,000.0
Underwriter Warrants in Connection with the February 2021 Common Stock Offering [Member] |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 1,682,927 |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 1.28125 |  | $ 1.28 |
Warrants and Rights Outstanding, Term (Year) | 5 years |  |  |
The May 2020 Offering Warrants [Member] |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 571,429 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 1.3125 | $ 1.3125 |
Warrants and Rights Outstanding, Term (Year) |  | 5 years |  |
Prior Warrant [Member] |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 5,000,000 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 0.35 |  |
Class of Warrant or Right, Exchange, Additional Consideration Per Share (in dollars per share) |  | $ 0.125 |  |
New Warrants Issued May 8, 2020 [Member] |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 5,000,000 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 0.5263 |  |
The May 2020 PA Warrants [Member] | H.C Wainwright & Co., LLC [Member] |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 250,000 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 0.5938 |  |
Public Offering, Inclusive of Underwriter Shares [Member] |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | 33,658,538 |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ 1.025 |  |  |
Underwriter Option to Purchase Additional Shares, Term (Day) | 30 days |  |  |
Proceeds from Issuance of Common Stock | $ 31,100,000 |  |  |
The May 2020 Offering [Member] |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  | 11,428,572 |  |
Shares Issued, Price Per Share (in dollars per share) |  | $ 1.05 |  |
Proceeds from Issuance of Common Stock |  | $ 10,300,000 |  |

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