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Note 7 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Stock-based compensation expense | $ 897,260 | $ 736,119
Research and Development Expense [Member] |  |
Stock-based compensation expense | 154,041 | 164,791
General and Administrative Expense [Member] |  |
Stock-based compensation expense | $ 743,219 | $ 571,328

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