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Note 8 - Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2022

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Three Months Ended September 30,								Nine Months Ended September 30,
		2022				2021				2022				2021
Research and development		$	46,704			$	18,811			$	164,489			$	111,378
General and administrative			135,177				145,581				573,653				531,574
Total stock-based compensation expense		$	181,881			$	164,392			$	738,142			$	642,952

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)				Aggregate intrinsic value
Balance at January 1, 2022			72,454			$	265.91
Granted			77,088				9.87							$	6,279
Forfeited			(7,603	)			144.62
Expired			(439	)			1,575.00
Outstanding at September 30, 2022			141,500			$	128.77				8.7				—
Exercisable at September 30, 2022			68,062			$	251.37				8.0				—
Vested and expected to vest at September 30, 2022			141,500			$	128.77				8.7				—

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		2022				2021
Expected term (in years)			5.7				10
Risk-free interest rate			1.7	%			1.5	%
Expected volatility			121.4	%			123.8	%
Dividend yield			—	%			—	%

Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]

		Number of Units				Weighted average grant date fair value
Balance at January 1, 2022			5,509			$	34.78
Vested (1)			(1,347	)			30.93
Outstanding at September 30, 2022			4,162			$	36.02

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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