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Note 8 - Stock-based Compensation - Stock Option Activity (Details)
 9 Months Ended
Sep. 30, 2022
USD ($)
$ / shares
shares
Balance (in shares) | shares 72,454
Balance (in dollars per share) | $ / shares $ 265.91
Granted (in shares) | shares 77,088
Granted, weighted-average exercise price (in dollars per share) | $ / shares $ 9.87
Forfeited (in shares) | shares (7,603)
Forfeited (in dollars per share) | $ / shares $ 144.62
Expired (in shares) | shares (439)
Expired (in dollars per share) | $ / shares $ 1,575.00
Options outstanding, number (in shares) | shares 141,500
Options outstanding, weighted-average exercise price (in dollars per share) | $ / shares $ 128.77
Options outstanding, weighted-average remaining contractual life (Year) 8 years 8 months 12 days
Options outstanding, aggregate intrinsic value | $ $ 0
Exercisable (in shares) | shares 68,062
Exercisable, weighted-average exercise price (in dollars per share) | $ / shares $ 251.37
Exercisable, weighted-average remaining contractual life (Year) 8 years
Exercisable, aggregate intrinsic value | $ $ 0
Vested and expected to vest (in shares) | shares 141,500
Vested and expected to vest, weighted-average exercise price (in dollars per share) | $ / shares $ 128.77
Vested and expected to vest, weighted-average remaining contractual life (Year) 8 years 8 months 12 days
Vested and expected to vest, aggregate intrinsic value | $ $ 0