    <SEC-DOCUMENT>0001437749-22-028255-index.html : 20221201
    <SEC-HEADER>0001437749-22-028255.hdr.sgml : 20221201
    <ACCEPTANCE-DATETIME>20221201092602
    ACCESSION NUMBER:		0001437749-22-028255
    CONFORMED SUBMISSION TYPE:	PRER14A
    PUBLIC DOCUMENT COUNT:		6
    FILED AS OF DATE:		20221201
    DATE AS OF CHANGE:		20221201

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		PRER14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37942
    		FILM NUMBER:		221437586

    	BUSINESS ADDRESS:
    		STREET 1:		300 EAST MAIN STREET
    		STREET 2:		SUITE 201
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		300 EAST MAIN STREET
    		STREET 2:		SUITE 201
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>PRER14A
    <SEQUENCE>1
    <FILENAME>dffn20221130_prer14a.htm
    <TEXT>
    Document 1 - file: dffn20221130_prer14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>dffn20221117_prec14aimg001.jpg
    <TEXT>
    Document 2 - file: dffn20221117_prec14aimg001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>dffn20221117_prec14aimg002.jpg
    <TEXT>
    Document 3 - file: dffn20221117_prec14aimg002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>dffn20221117_prec14aimg003.jpg
    <TEXT>
    Document 4 - file: dffn20221117_prec14aimg003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>pc01.jpg
    <TEXT>
    Document 5 - file: pc01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>pc02.jpg
    <TEXT>
    Document 6 - file: pc02.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>