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Note 8 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021
Research and development | $ 928,052 | $ 897,260
Research and Development Expense [Member] |  |
Research and development | 215,904 | 154,041
General and Administrative Expense [Member] |  |
Research and development | $ 712,148 | $ 743,219

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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