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Note 10 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Notes Tables |
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] |
|  | December 31, 2022 |  |  | December 31, 2021 |
Federal |  | $ | — |  |  | $ | (362,150 | )
State |  |  | — |  |  |  | (81,743 | )
Total |  |  | — |  |  |  | (443,893 | )
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
Deferred tax assets |  | December 31, 2022 |  |  | December 31, 2021 |
Net operating loss carryforwards |  | $ | 8,650,404 |  |  | $ | 6,033,726 |
Stock option compensation |  |  | 1,754,906 |  |  |  | 1,641,354 |
Orphan Drug credits |  |  | 1,306,682 |  |  |  | 647,937 |
Capitalized start-up costs and other |  |  | 12,788,834 |  |  |  | 12,403,925 |
Valuation allowance |  |  | (24,471,392 | ) |  |  | (20,726,942 | )
Deferred tax assets |  | $ | — |  |  | $ | — |
Summary of Operating Loss Carryforwards [Table Text Block] |
Combined NOL Carryforwards: |  | December 31, 2022 |  |  | December 31, 2021 |
Federal |  | $ | 34,116,553 |  |  | $ | 23,442,045 |
State |  |  | 30,727,733 |  |  |  | 23,436,624 |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
Rate reconciliation: |  | December 31, 2022 |  |  | December 31, 2021 |
Federal tax benefit at statutory rate |  |  | (21.0 | )% |  |  | (21.0 | )%
State tax, net of Federal benefit |  |  | (3.9 | )% |  |  | (4.7 | )%
Orphan drug credit |  |  | (4.5 | )% |  |  | (0.4 | )%
Change in valuation allowance |  |  | 29.0 | % |  |  | 24.3 | %
Stock compensation |  |  | 0.4 | % |  |  | — | %
Other |  |  | — | % |  |  | — | %
Total provision |  |  | — | % |  |  | (1.8 | )%

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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- Definition Tabular disclosure of pertinent information, such as tax authority, amounts, and expiration dates, of net operating loss carryforwards, including an assessment of the likelihood of utilization. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32559-109319 + Details
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