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Note 8- Stock-based Compensation (Tables)

6 Months Ended

Jun. 30, 2023

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Three Months Ended June 30,								Six Months Ended June 30,
		2023				2022				2023				2022
Research and development		$	—			$	58,892			$	12,011			$	117,785
General and administrative			60,665				219,238				170,025				438,476
Total stock-based compensation expense		$	60,665			$	278,130			$	182,036			$	556,261

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)				Aggregate intrinsic value
Balance at January 1, 2023			140,040			$	126.75
Granted			—				—
Cancelled			(54,079	)			22.04
Outstanding at June 30, 2023			85,961			$	192.65				7.65			$	—
Exercisable at June 30, 2023			68,344			$	238.46				7.42			$	—
Vested and expected to vest at June 30, 2023			85,961			$	192.65				7.65			$	—

Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]

		Number of Units				Weighted average grant date fair value
Balance at January 1, 2022			3,652			$	36.49
Vested (1)			(1,157	)			36.04
Outstanding at June 30, 2023			2,495			$	37.57

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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