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Note 8 - Stock-based Compensation - Stock Option Activity (Details)
$ / shares in Units, $ in Thousands
 6 Months Ended
Jun. 30, 2023
USD ($)
$ / shares
shares
Balance, number of shares (in shares) | shares 140,040
Balance, weighted average exercise price (in dollars per share) | $ / shares $ 126.75
Granted, number of shares (in shares) | shares 0
Granted, weighted average exercise price (in dollars per share) | $ / shares $ 0
Cancelled, number of shares (in shares) | shares (54,079)
Cancelled, weighted average exercise price (in dollars per share) | $ / shares $ 22.04
Outstanding , number of shares (in shares) | shares 85,961
Outstanding, weighted average exercise price (in dollars per share) | $ / shares $ 192.65
Outstanding, remaining term (Year) 7 years 7 months 24 days
Outstanding, intrinsic value | $ $ 0
Exercisable, number of shares (in shares) | shares 68,344
Exercisable, weighted average exercise price (in dollars per share) | $ / shares $ 238.46
Exercisable, remaining term (Year) 7 years 5 months 1 day
Exercisable, intrinsic value | $ $ 0
Vested and expected to vest, number of shares (in shares) | shares 85,961
Vested and expected to vest, weighted average exercise price (in dollars per share) | $ / shares $ 192.65
Vested and expected to vest, remaining term (Year) 7 years 7 months 24 days
Vested and expected to vest , intrinsic value | $ $ 0