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Note 12 - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 3 Months Ended | 9 Months Ended
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Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022
Share based compensation expense | $ 109,168 | $ 82,384 | $ 242,660 | $ 252,847
Research and Development Expense [Member] |  |  |  |
Share based compensation expense | 30,737 | 41,546 | 101,885 | 134,559
General and Administrative Expense [Member] |  |  |  |
Share based compensation expense | $ 78,431 | $ 40,838 | $ 140,775 | $ 118,288

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