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Note 12 - Stock-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2023
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2023 |  |  | 2022 |  |  | 2023 |  |  | 2022 |
Research and development |  | $ | 30,737 |  |  | $ | 41,546 |  |  | $ | 101,885 |  |  | $ | 134,559 |
General and administrative |  |  | 78,431 |  |  |  | 40,838 |  |  |  | 140,775 |  |  |  | 118,288 |
Total stock-based compensation expense |  | $ | 109,168 |  |  | $ | 82,384 |  |  | $ | 242,660 |  |  | $ | 252,847 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |
Balance at January 1, 2023 |  |  | 114,516 |  |  | $ | 25.98 |
Options assumed in the Merger |  |  | 52,574 |  |  | $ | 313.67 |
Granted |  |  | 162,250 |  |  | $ | 5.33 |
Outstanding at September 30, 2023 |  |  | 329,340 |  |  | $ | 61.73 |
Exercisable at September 30, 2023 |  |  | 148,912 |  |  | $ | 111.77 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | September 30, |
|  | 2023 |  |  | 2022 |
Expected term (in years) |  |  | 5.75 |  |  |  | 6.00 |
Risk-free interest rate |  |  | 4.4% |  |  |  | 1.9% |
Expected volatility |  |  | 81.7% |  |  |  | 80.3% |
Dividend yield |  |  | 0.0% |  |  |  | 0.0% |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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