    <SEC-DOCUMENT>0001437749-23-013739-index.html : 20230511
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    <ACCEPTANCE-DATETIME>20230510215612
    ACCESSION NUMBER:		0001437749-23-013739
    CONFORMED SUBMISSION TYPE:	S-4
    PUBLIC DOCUMENT COUNT:		36
    FILED AS OF DATE:		20230511
    DATE AS OF CHANGE:		20230510

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-4
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-271823
    		FILM NUMBER:		23908593

    	BUSINESS ADDRESS:
    		STREET 1:		300 EAST MAIN STREET
    		STREET 2:		SUITE 201
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		300 EAST MAIN STREET
    		STREET 2:		SUITE 201
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-4
    <SEQUENCE>1
    <FILENAME>dffn20230501_s4.htm
    <DESCRIPTION>FORM S-4
    <TEXT>
    Document 1 - file: dffn20230501_s4.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.23
    <SEQUENCE>2
    <FILENAME>ex_515228.htm
    <DESCRIPTION>EXHIBIT 10.23
    <TEXT>
    Document 2 - file: ex_515228.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.24
    <SEQUENCE>3
    <FILENAME>ex_515229.htm
    <DESCRIPTION>EXHIBIT 10.24
    <TEXT>
    Document 3 - file: ex_515229.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.25
    <SEQUENCE>4
    <FILENAME>ex_515230.htm
    <DESCRIPTION>EXHIBIT 10.25
    <TEXT>
    Document 4 - file: ex_515230.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.26
    <SEQUENCE>5
    <FILENAME>ex_515231.htm
    <DESCRIPTION>EXHIBIT 10.26
    <TEXT>
    Document 5 - file: ex_515231.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.27
    <SEQUENCE>6
    <FILENAME>ex_518494.htm
    <DESCRIPTION>EXHIBIT 10.27
    <TEXT>
    Document 6 - file: ex_518494.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.28
    <SEQUENCE>7
    <FILENAME>ex_515232.htm
    <DESCRIPTION>EXHIBIT 10.28
    <TEXT>
    Document 7 - file: ex_515232.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.29
    <SEQUENCE>8
    <FILENAME>ex_515233.htm
    <DESCRIPTION>EXHIBIT 10.29
    <TEXT>
    Document 8 - file: ex_515233.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.30
    <SEQUENCE>9
    <FILENAME>ex_515234.htm
    <DESCRIPTION>EXHIBIT 10.30
    <TEXT>
    Document 9 - file: ex_515234.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.31
    <SEQUENCE>10
    <FILENAME>ex_515235.htm
    <DESCRIPTION>EXHIBIT 10.31
    <TEXT>
    Document 10 - file: ex_515235.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>11
    <FILENAME>ex_517279.htm
    <DESCRIPTION>EXHIBIT 23.1
    <TEXT>
    Document 11 - file: ex_517279.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.2
    <SEQUENCE>12
    <FILENAME>ex_518004.htm
    <DESCRIPTION>EXHIBIT 23.2
    <TEXT>
    Document 12 - file: ex_518004.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>13
    <FILENAME>ex_515236.htm
    <DESCRIPTION>EXHIBIT 99.1
    <TEXT>
    Document 13 - file: ex_515236.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.2
    <SEQUENCE>14
    <FILENAME>ex_515237.htm
    <DESCRIPTION>EXHIBIT 99.2
    <TEXT>
    Document 14 - file: ex_515237.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.3
    <SEQUENCE>15
    <FILENAME>ex_515238.htm
    <DESCRIPTION>EXHIBIT 99.3
    <TEXT>
    Document 15 - file: ex_515238.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.4
    <SEQUENCE>16
    <FILENAME>ex_515239.htm
    <DESCRIPTION>EXHIBIT 99.4
    <TEXT>
    Document 16 - file: ex_515239.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.5
    <SEQUENCE>17
    <FILENAME>ex_515240.htm
    <DESCRIPTION>EXHIBIT 99.5
    <TEXT>
    Document 17 - file: ex_515240.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.8
    <SEQUENCE>18
    <FILENAME>ex_518310.htm
    <DESCRIPTION>EXHIBIT 99.8
    <TEXT>
    Document 18 - file: ex_518310.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>19
    <FILENAME>ex_518417.htm
    <DESCRIPTION>EXHIBIT FILING FEES
    <TEXT>
    Document 19 - file: ex_518417.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>a01.jpg
    <TEXT>
    Document 20 - file: a01.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>a02.jpg
    <TEXT>
    Document 21 - file: a02.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>cglogo.jpg
    <TEXT>
    Document 22 - file: cglogo.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>dp01.jpg
    <TEXT>
    Document 23 - file: dp01.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>eippharma01.jpg
    <TEXT>
    Document 24 - file: eippharma01.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>graph01.jpg
    <TEXT>
    Document 25 - file: graph01.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>graph02.jpg
    <TEXT>
    Document 26 - file: graph02.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>graph03.jpg
    <TEXT>
    Document 27 - file: graph03.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>graph04.jpg
    <TEXT>
    Document 28 - file: graph04.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>graph05.jpg
    <TEXT>
    Document 29 - file: graph05.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>graph06.jpg
    <TEXT>
    Document 30 - file: graph06.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>graph07.jpg
    <TEXT>
    Document 31 - file: graph07.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>graph08.jpg
    <TEXT>
    Document 32 - file: graph08.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>graph09.jpg
    <TEXT>
    Document 33 - file: graph09.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>graph10.jpg
    <TEXT>
    Document 34 - file: graph10.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>graph11.jpg
    <TEXT>
    Document 35 - file: graph11.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>graph12.jpg
    <TEXT>
    Document 36 - file: graph12.jpg

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