SEC EDGAR Submission 0001437749-23-013739

<SEC-DOCUMENT>0001437749-23-013739-index.html : 20230511
<SEC-HEADER>0001437749-23-013739.hdr.sgml : 20230511
<ACCEPTANCE-DATETIME>20230510215612
ACCESSION NUMBER:		0001437749-23-013739
CONFORMED SUBMISSION TYPE:	S-4
PUBLIC DOCUMENT COUNT:		36
FILED AS OF DATE:		20230511
DATE AS OF CHANGE:		20230510

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001053691
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				300645032
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-4
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-271823
		FILM NUMBER:		23908593

	BUSINESS ADDRESS:	
		STREET 1:		300 EAST MAIN STREET
		STREET 2:		SUITE 201
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		(434) 220-0718

	MAIL ADDRESS:	
		STREET 1:		300 EAST MAIN STREET
		STREET 2:		SUITE 201
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RestorGenex Corp
		DATE OF NAME CHANGE:	20140307

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Stratus Media Group, Inc
		DATE OF NAME CHANGE:	20080722

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
		DATE OF NAME CHANGE:	20080228
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-4
<SEQUENCE>1
<FILENAME>dffn20230501_s4.htm
<DESCRIPTION>FORM S-4
<TEXT>
Document 1 - file: dffn20230501_s4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.23
<SEQUENCE>2
<FILENAME>ex_515228.htm
<DESCRIPTION>EXHIBIT 10.23
<TEXT>
Document 2 - file: ex_515228.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.24
<SEQUENCE>3
<FILENAME>ex_515229.htm
<DESCRIPTION>EXHIBIT 10.24
<TEXT>
Document 3 - file: ex_515229.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.25
<SEQUENCE>4
<FILENAME>ex_515230.htm
<DESCRIPTION>EXHIBIT 10.25
<TEXT>
Document 4 - file: ex_515230.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.26
<SEQUENCE>5
<FILENAME>ex_515231.htm
<DESCRIPTION>EXHIBIT 10.26
<TEXT>
Document 5 - file: ex_515231.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.27
<SEQUENCE>6
<FILENAME>ex_518494.htm
<DESCRIPTION>EXHIBIT 10.27
<TEXT>
Document 6 - file: ex_518494.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.28
<SEQUENCE>7
<FILENAME>ex_515232.htm
<DESCRIPTION>EXHIBIT 10.28
<TEXT>
Document 7 - file: ex_515232.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.29
<SEQUENCE>8
<FILENAME>ex_515233.htm
<DESCRIPTION>EXHIBIT 10.29
<TEXT>
Document 8 - file: ex_515233.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.30
<SEQUENCE>9
<FILENAME>ex_515234.htm
<DESCRIPTION>EXHIBIT 10.30
<TEXT>
Document 9 - file: ex_515234.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.31
<SEQUENCE>10
<FILENAME>ex_515235.htm
<DESCRIPTION>EXHIBIT 10.31
<TEXT>
Document 10 - file: ex_515235.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>11
<FILENAME>ex_517279.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 11 - file: ex_517279.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>12
<FILENAME>ex_518004.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
Document 12 - file: ex_518004.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>13
<FILENAME>ex_515236.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
Document 13 - file: ex_515236.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>14
<FILENAME>ex_515237.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
Document 14 - file: ex_515237.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>15
<FILENAME>ex_515238.htm
<DESCRIPTION>EXHIBIT 99.3
<TEXT>
Document 15 - file: ex_515238.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.4
<SEQUENCE>16
<FILENAME>ex_515239.htm
<DESCRIPTION>EXHIBIT 99.4
<TEXT>
Document 16 - file: ex_515239.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.5
<SEQUENCE>17
<FILENAME>ex_515240.htm
<DESCRIPTION>EXHIBIT 99.5
<TEXT>
Document 17 - file: ex_515240.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.8
<SEQUENCE>18
<FILENAME>ex_518310.htm
<DESCRIPTION>EXHIBIT 99.8
<TEXT>
Document 18 - file: ex_518310.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>19
<FILENAME>ex_518417.htm
<DESCRIPTION>EXHIBIT FILING FEES
<TEXT>
Document 19 - file: ex_518417.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>20
<FILENAME>a01.jpg
<TEXT>
Document 20 - file: a01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>21
<FILENAME>a02.jpg
<TEXT>
Document 21 - file: a02.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>22
<FILENAME>cglogo.jpg
<TEXT>
Document 22 - file: cglogo.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>23
<FILENAME>dp01.jpg
<TEXT>
Document 23 - file: dp01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>24
<FILENAME>eippharma01.jpg
<TEXT>
Document 24 - file: eippharma01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>25
<FILENAME>graph01.jpg
<TEXT>
Document 25 - file: graph01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>26
<FILENAME>graph02.jpg
<TEXT>
Document 26 - file: graph02.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>27
<FILENAME>graph03.jpg
<TEXT>
Document 27 - file: graph03.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>28
<FILENAME>graph04.jpg
<TEXT>
Document 28 - file: graph04.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>29
<FILENAME>graph05.jpg
<TEXT>
Document 29 - file: graph05.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>30
<FILENAME>graph06.jpg
<TEXT>
Document 30 - file: graph06.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>31
<FILENAME>graph07.jpg
<TEXT>
Document 31 - file: graph07.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>32
<FILENAME>graph08.jpg
<TEXT>
Document 32 - file: graph08.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>33
<FILENAME>graph09.jpg
<TEXT>
Document 33 - file: graph09.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>34
<FILENAME>graph10.jpg
<TEXT>
Document 34 - file: graph10.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>35
<FILENAME>graph11.jpg
<TEXT>
Document 35 - file: graph11.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>36
<FILENAME>graph12.jpg
<TEXT>
Document 36 - file: graph12.jpg

</DOCUMENT>
</SEC-DOCUMENT>