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Note 4 - Cash, Cash Equivalents and Marketable Securities | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2023 | Dec. 31, 2022
Notes to Financial Statements |  |
Cash, Cash Equivalents, and Marketable Securities [Text Block] |
4. | Cash, cash equivalents and marketable securities
The following is a summary of the Company's cash and cash equivalents as of the date indicated:
|  | March 31, 2023 |  |  | December 31, 2022 |
Cash in banking institutions |  | $ | 631,002 |  |  | $ | 1,586,920 |
Money market funds |  |  | 14,014,584 |  |  |  | 8,526,786 |
Total |  | $ | 14,645,586 |  |  | $ | 10,113,706 |
The following is a summary of the Company's marketable securities as of as of the date indicated:
|  | Amortized cost |  |  | Unrealized gains |  |  | Unrealized losses |  |  | Fair Value |
March 31, 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commercial paper |  | $ | 1,995,318 |  |  |  | 210 |  |  | $ | (1,437 | ) |  | $ | 1,994,091 |
U.S. treasury bonds |  |  | 999,575 |  |  |  | — |  |  |  | (1,896 | ) |  |  | 997,679 |
Total |  | $ | 2,994,893 |  |  |  | 210 |  |  | $ | (3,333 | ) |  | $ | 2,991,770 |
December 31, 2022 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commercial paper |  | $ | 9,445,220 |  |  |  | 263 |  |  | $ | (21,313 | ) |  | $ | 9,424,170 |
U.S. treasury bonds |  |  | 2,999,095 |  |  |  | — |  |  |  | (14,325 | ) |  |  | 2,984,770 |
Total |  | $ | 12,444,315 |  |  |  | 263 |  |  | $ | (35,638 | ) |  | $ | 12,408,940 |
The Company's marketable securities generally have contractual maturity dates between 7 and 30 months. As of March 31, 2023, $1,991,770 of the marketable securities held were in an unrealized loss position, all of which have been in an unrealized loss position for less than twelve months. The Company determined that unrealized losses on marketable securities were primarily due to market conditions, including changes in the U.S. Federal Reserve interest rate, and not credit losses. The Company does not intend to sell the investments and it is not more likely than not that that the Company will be required to sell the investments before the recovery of the amortized cost basis. No allowance for credit losses related to any of these securities was recorded for the three months ended March 31, 2023. | 4. Cash, cash equivalents and marketable securities The following is a summary of the Company's cash and cash equivalents as of the dates indicated:
|  | December 31, |
|  | 2022 |  |  | 2021 |
Cash in banking institutions |  | $ | 1,586,920 |  |  | $ | 30,308,075 |
Money market funds |  |  | 8,526,786 |  |  |  | 7,005,483 |
Total |  | $ | 10,113,706 |  |  | $ | 37,313,558 |
The following is a summary of the Company's marketable securities as of December 31, 2022:
|  | Amortized cost |  |  | Unrealized gains |  |  | Unrealized losses |  |  | Fair Value |
Commercial paper |  | $ | 9,445,220 |  |  | $ | 263 |  |  | $ | (21,313 | ) |  | $ | 9,424,170 |
U.S. treasury bonds |  |  | 2,999,095 |  |  |  | — |  |  |  | (14,325 | ) |  |  | 2,984,770 |
Total |  | $ | 12,444,315 |  |  | $ | 263 |  |  | $ | (35,638 | ) |  | $ | 12,408,940 |
The Company did not have any marketable securities as of December 31, 2021. The Company's marketable securities generally have contractual maturity dates between 3 and 12 months. All but one of the Company’s marketable securities are in an unrealized loss position at December 31, 2022. Unrealized losses on marketable securities as of December 31, 2022 were $35,638 and were primarily due to changes in interest rates, and not due to increased credit risks associated with specific securities. Accordingly, no other-than-temporary impairment was recorded for the year ended December 31, 2022 and there were no realized gains or losses recorded during the year ended December 31, 2022.

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- Definition The entire disclosure of cash, cash equivalents, and debt and equity securities, including any unrealized or realized gain (loss). + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 320 -Name Accounting Standards Codification -Publisher FASB -URI https://asc.fasb.org//320/tableOfContent + Details
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