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Note 7 - Stockholders' Equity and Common Stock Warrants | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2023 | Dec. 31, 2022
Notes to Financial Statements |  |
Equity [Text Block] |
7. | Stockholders' Equity and Common Stock Warrants
Common Stock Warrants As of March 31, 2023, the Company had the following warrants outstanding to acquire shares of its common stock:
|  | Outstanding |  |  | Range of exercise price per share |  | Expiration dates
Common stock warrants issued related to the May 2019 common stock offering |  |  | 27,648 |  |  |  | $250.09 | - | $306.04 |  | May and December 2024
Common stock warrants issued related to the November 2019 common stock offering |  |  | 4,269 |  |  |  |  | $17.51 |  |  | May 2024
Common stock warrants issued related to the December 2019 common stock offering |  |  | 6,264 |  |  |  | $21.68 | - | $34.92 |  | December 2024 and June 2025
Common stock warrants issued related to the May 2020 common stock offering |  |  | 11,424 |  |  |  |  | $65.65 |  |  | March 2025
Common stock warrants issued related to the May 2020 investor warrant exercise |  |  | 4,998 |  |  |  |  | $29.7 |  |  | November 2025
Common stock warrants issued related to the February 2021 common stock offering |  |  | 33,649 |  |  |  |  | $64.08 |  |  | February 2026
|  |  | 88,252 |  |  |  |  |  |  |  |
During the three months ended March 31, 2023, 23,639 warrants expired. | 7. Stockholders' Equity and Common Stock Warrants Common Stock Warrants As of December 31, 2022, the Company had the following warrants outstanding to acquire shares of its common stock:
|  | Outstanding |  |  | Range of exercise price per share |  | Expiration dates
Common stock warrants issued in 2018 related to the January 2018 Offering |  |  | 23,639 |  |  | $599.71 | - | $749.76 |  | January 2023
Common stock warrants issued related to the May 2019 Offering |  |  | 27,648 |  |  | $250.09 | - | $306.04 |  | May and December 2024
Common stock warrants issued related to the November 2019 Offering |  |  | 4,269 |  |  |  | $17.51 |  |  | November 2024
Common stock warrants issued related to the December 2019 Offering |  |  | 6,264 |  |  | $21.68 | - | $34.92 |  | December 2024 and June 2025
Common stock warrants issued related to the May 2020 Offering |  |  | 11,424 |  |  |  | $65.65 |  |  | March 2025
Common stock warrants issued related to the May 2020 Investor Warrant Exercise |  |  | 4,998 |  |  |  | $29.70 |  |  | November 2025
Common stock warrants issued related to the February 2021 Offering |  |  | 33,649 |  |  |  | $64.08 |  |  | February 2026
|  |  | 111,891 |  |  |  |  |  |  |
During the years ended December 31, 2022 and 2021, 18,077 and 1,071 warrants expired, respectively.

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