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Note 10 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Statement [Line Items] |  |
Net operating loss carryforwards | $ 8,650,404 | $ 6,033,726
Stock option compensation | 1,754,906 | 1,641,354
Orphan Drug credits | 1,306,682 | 647,937
Capitalized start-up costs and other | 12,788,834 | 12,403,925
Valuation allowance | (24,471,392) | (20,726,942)
Deferred tax assets | $ 0 | $ 0

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