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Note 7 - Stockholders' Equity and Common Stock Warrants (10 Q) (Details Textual) - shares | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Class of Warrant or Rights, Expired | 23,639 | 18,077 | 1,071

X
- Definition Number of warrants or rights expired. + References No definition available. + Details
Name: | dffn_ClassOfWarrantOrRightsExpired
Namespace Prefix: | dffn_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration