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Note 8- Stock-based Compensation (10 Q) (Tables) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2023 | Dec. 31, 2022
Notes Tables |  |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended March 31, |
|  | 2023 |  |  | 2022 |
Research and development |  | $ | 12,011 |  |  | $ | 58,892 |
General and administrative |  |  | 109,360 |  |  |  | 219,239 |
Total stock-based compensation expense |  | $ | 121,371 |  |  | $ | 278,131 |
|  | December 31, |
|  | 2022 |  |  | 2021 |
Research and development |  | $ | 215,904 |  |  | $ | 154,041 |
General and administrative |  |  | 712,148 |  |  |  | 743,219 |
Total stock-based compensation expense |  | $ | 928,052 |  |  | $ | 897,260 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate intrinsic value |
Balance at January 1, 2023 |  |  | 140,040 |  |  | $ | 126.75 |  |  |  |  |  |  |  |  |
Granted |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Cancelled |  |  | (35,993 | ) |  |  | 20.13 |  |  |  |  |  |  |  |  |
Outstanding at March 31, 2023 |  |  | 104,047 |  |  | $ | 163.64 |  |  |  | 7.99 |  |  | $ | — |
Exercisable at March 31, 2023 |  |  | 78,533 |  |  | $ | 211.21 |  |  |  | 7.75 |  |  | $ | — |
Vested and expected to vest at March 31, 2023 |  |  | 104,047 |  |  | $ | 163.64 |  |  |  | 7.99 |  |  | $ | — |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual term (in years) |  |  | Aggregate Intrinsic Value |
Balance at January 1, 2021 |  |  | 44,738 |  |  | $ | 407.60 |  |  |  |  |  |  |  |  |
Granted |  |  | 36,310 |  |  |  | 44.66 |  |  |  |  |  |  |  |  |
Expired |  |  | (8,594 | ) |  |  | 68.48 |  |  |  |  |  |  |  |  |
Balance at December 31, 2021 |  |  | 72,454 |  |  |  | 265.91 |  |  |  |  |  |  |  |  |
Granted |  |  | 77,088 |  |  |  | 9.87 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (8,892 | ) |  |  | 147.28 |  |  |  |  |  |  |  |  |
Expired |  |  | (610 | ) |  |  | 1,562.92 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2022 |  |  | 140,040 |  |  |  | 126.75 |  |  |  | 8.5 |  |  |  | — |
Exercisable at December 31, 2022 |  |  | 74,086 |  |  | $ | 226.95 |  |  |  | 7.9 |  |  |  | — |
Vested and expected to vest at December 31, 2022 |  |  | 140,040 |  |  | $ | 126.75 |  |  |  | 8.5 |  |  |  | — |
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] |
|  | Number of Units |  |  | Weighted average grant date fair value |
Balance at January 1, 2023 |  |  | 3,652 |  |  | $ | 36.49 |
Vested (1) |  |  | (742 | ) |  |  | 33.72 |
Outstanding at March 31, 2023 |  |  | 2,910 |  |  | $ | 38.28 |
|  | Number of Units |  |  | Weighted average grant date fair value |
Balance at January 1, 2022 |  |  | 5,509 |  |  | $ | 34.78 |
Vested(1) |  |  | (1,857 | ) |  |  | 31.41 |
Outstanding at December 31, 2022 |  |  | 3,652 |  |  |  | 36.49 |

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