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Note 8 - Stock-based Compensation - Stock-based Compensation Expense (10 Q) (Details) - USD ($) | 3 Months Ended | 12 Months Ended
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Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | Dec. 31, 2021
Total stock-based compensation expense | $ 121,371 | $ 278,131 | $ 928,052 | $ 897,260
Research and Development Expense [Member] |  |  |  |
Total stock-based compensation expense | 12,011 | 58,892 | 215,904 | 154,041
General and Administrative Expense [Member] |  |  |  |
Total stock-based compensation expense | $ 109,360 | $ 219,239 | $ 712,148 | $ 743,219

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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