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Note 11 - Stock-based Compensation Stock - Stock-based Compensation Expense (Details) - USD ($) | 3 Months Ended | 6 Months Ended
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Jun. 30, 2024 | Jun. 30, 2023 | Jun. 30, 2024 | Jun. 30, 2023
Share based compensation expense | $ 578,581 | $ 62,252 | $ 796,796 | $ 133,492
Research and Development Expense [Member] |  |  |  |
Share based compensation expense | 40,337 | 31,022 | 104,134 | 71,148
General and Administrative Expense [Member] |  |  |  |
Share based compensation expense | $ 538,244 | $ 31,230 | $ 692,662 | $ 62,344

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