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Note 11 - Stock-based Compensation Stock (Tables) | 6 Months Ended
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Jun. 30, 2024
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2024 |  |  | 2023 |  |  | 2024 |  |  | 2023 |
Research and development |  | $ | 40,337 |  |  | $ | 31,022 |  |  | $ | 104,134 |  |  | $ | 71,148 |
General and administrative |  |  | 538,244 |  |  |  | 31,230 |  |  |  | 692,662 |  |  |  | 62,344 |
Total stock-based compensation expense |  | $ | 578,581 |  |  | $ | 62,252 |  |  | $ | 796,796 |  |  | $ | 133,492 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate intrinsic value |
Balance at January 1, 2024 |  |  | 349,374 |  |  | $ | 51.15 |  |  |  |  |  |  |  |  |
Granted |  |  | 207,284 |  |  |  | 11.23 |  |  |  |  |  |  |  |  |
Cancelled/Expired |  |  | (23,354 | ) |  |  | 114.18 |  |  |  |  |  |  |  |  |
Outstanding at June 30, 2024 |  |  | 533,304 |  |  | $ | 32.87 |  |  |  | 8.4 |  |  |  | — |
Exercisable at June 30, 2024 |  |  | 228,508 |  |  | $ | 64.13 |  |  |  | 6.7 |  |  |  | — |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Six Months Ended June 30, |
|  | 2024 |
Expected term (in years) |  | 5.25 | - | 5.76 |
Risk-free interest rate |  | 4.06 | - | 4.46% |
Expected volatility |  | 76.87 | - | 80.03% |
Dividend yield |  |  | — |  |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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