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Note 11 - Stock-based Compensation Stock (Tables)

6 Months Ended

Jun. 30, 2024

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Three Months Ended June 30,								Six Months Ended June 30,
		2024				2023				2024				2023
Research and development		$	40,337			$	31,022			$	104,134			$	71,148
General and administrative			538,244				31,230				692,662				62,344
Total stock-based compensation expense		$	578,581			$	62,252			$	796,796			$	133,492

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)				Aggregate intrinsic value
Balance at January 1, 2024			349,374			$	51.15
Granted			207,284				11.23
Cancelled/Expired			(23,354	)			114.18
Outstanding at June 30, 2024			533,304			$	32.87				8.4				—
Exercisable at June 30, 2024			228,508			$	64.13				6.7				—

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Six Months Ended June 30,
		2024
Expected term (in years)		5.25	-	5.76
Risk-free interest rate		4.06	-	4.46%
Expected volatility		76.87	-	80.03%
Dividend yield			—

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

+ References

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-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
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- Definition

Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

+ References

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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