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Note 12 - Stock-based Compensation Stock - Stock-based Compensation Expense (Details) - USD ($) | 3 Months Ended | 9 Months Ended
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Sep. 30, 2024 | Sep. 30, 2023 | Sep. 30, 2024 | Sep. 30, 2023
Share based compensation expense | $ 271,215 | $ 109,168 | $ 1,068,011 | $ 242,660
Research and Development Expense [Member] |  |  |  |
Share based compensation expense | 42,224 | 30,737 | 146,358 | 101,885
General and Administrative Expense [Member] |  |  |  |
Share based compensation expense | $ 228,991 | $ 78,431 | $ 921,653 | $ 140,775

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