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Note 11 - Stock-based Compensation Expense - Stock-based Compensation Expense (Details) - USD ($) | 3 Months Ended | 9 Months Ended
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Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Share based compensation expense | $ 291,717 | $ 271,215 | $ 1,149,899 | $ 1,068,011
Research and Development Expense [Member] |  |  |  |
Share based compensation expense | 133,169 | 42,224 | 378,030 | 146,358
General and Administrative Expense [Member] |  |  |  |
Share based compensation expense | $ 158,548 | $ 228,991 | $ 771,869 | $ 921,653

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