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Note 5 - Significant Agreements and Contracts (Details Textual) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Jun. 30, 2025 | Mar. 31, 2025 | Aug. 31, 2014 | Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Aug. 31, 2024 | Jan. 31, 2023
Research and development expense |  |  |  | $ 6,040,442 | $ 5,125,097 | $ 15,986,865 | $ 11,711,746 |  |  |  |  |
Revenues |  |  |  | 322,569 | 1,939,751 | 3,997,784 | 7,575,972 |  |  |  |  |
Vertex Option and License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  | $ 100,000 |  |  |  |  |  |  |  |  |
Contractual Obligation |  |  | $ 117,000,000 |  |  |  |  |  |  |  |  |
Agreement, Milestone, Period for Net Sales |  |  | 12 months |  |  |  |  |  |  |  |  |
Agreement, Maximum Deduction Percentage of Fees and Payments |  |  | 50.00% |  |  |  |  |  |  |  |  |
Payments for License Agreement |  |  | $ 100,000 | 0 | 0 | 0 | 0 |  |  |  |  |
National Institute of Aging Grant [Member] |  |  |  |  |  |  |  |  |  |  |  |
Government Assistance, Asset |  |  |  |  |  |  |  |  |  |  | $ 300,000 | $ 21,000,000
Government Assistance, Income, Increase (Decrease) | $ 500,000 | $ 5,600,000 |  |  |  | 6,100,000 |  |  | $ 8,400,000 | $ 6,700,000 |  |
Revenues |  |  |  | 300,000 | $ 1,900,000 | 4,000,000 | $ 7,600,000 |  |  |  |  |
Proceeds From Grants |  |  |  |  |  | 19,500,000 |  |  |  |  |  |
Grant Funding Remaining |  |  |  | 1,600,000 |  | 1,600,000 |  |  |  |  |  |
Deferred Revenue, Current |  |  |  | $ 1,800,000 |  | $ 1,800,000 |  |  | $ 2,300,000 |  |  |
Grant Amount, Received, Percentage |  |  |  |  |  | 98.00% |  |  |  |  |  |
Grant Amount Remaining, Percentage |  |  |  |  |  | 2.00% |  |  |  |  |  |
National Institute of Aging Grant [Member] | Forecast [Member] |  |  |  |  |  |  |  |  |  |  |  |
Government Assistance, Income, Increase (Decrease) |  |  |  |  |  |  |  | $ 6,200,000 |  |  |  |

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