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Note 10 - Stock-based Compensation Expense (Tables)

9 Months Ended

Sep. 30, 2025

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Three Months Ended September 30,								Nine Months Ended September 30,
		2025				2024				2025				2024
Research and development		$	133,169			$	42,224			$	378,030			$	146,358
General and administrative			158,548				228,991				771,869				921,653
Total stock-based compensation expense		$	291,717			$	271,215			$	1,149,899			$	1,068,011

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual life (in years)				Aggregate intrinsic value
Balance at January 1, 2025			636,802			$	19.38				7.6
Granted			375,400				3.63
Expired			(16,828	)			60.14
Outstanding at September 30, 2025			995,374			$	12.75				7.1				—
Exercisable at September 30, 2025			536,826			$	18.38				5.9				—

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Nine Months Ended September 30,
		2025					2024
Expected term (in years)		5.24	-	5.76			5.25	-	5.76
Risk-free interest rate		3.93	-	4.35%			4.06	-	4.46%
Expected volatility		71.55	-	76.68%			76.87	-	80.03%
Dividend yield			—					—

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

+ References

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-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
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- Definition

Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

+ References

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- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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