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Note 5 - Significant Agreements and Contracts (Details Textual) - USD ($)
 1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Aug. 31, 2014
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Aug. 31, 2024
Jan. 31, 2023
Research and development expense       $ 6,040,442 $ 5,125,097 $ 15,986,865 $ 11,711,746          
Revenues       322,569 1,939,751 3,997,784 7,575,972          
Vertex Option and License Agreement [Member]                        
Research and development expense     $ 100,000                  
Contractual Obligation     $ 117,000,000                  
Agreement, Milestone, Period for Net Sales     12 months                  
Agreement, Maximum Deduction Percentage of Fees and Payments     50.00%                  
Payments for License Agreement     $ 100,000 0 0 0 0          
National Institute of Aging Grant [Member]                        
Government Assistance, Asset                     $ 300,000 $ 21,000,000
Government Assistance, Income, Increase (Decrease) $ 500,000 $ 5,600,000       6,100,000     $ 8,400,000 $ 6,700,000    
Revenues       300,000 $ 1,900,000 4,000,000 $ 7,600,000          
Proceeds From Grants           19,500,000            
Grant Funding Remaining       1,600,000   1,600,000            
Deferred Revenue, Current       $ 1,800,000   $ 1,800,000     $ 2,300,000      
Grant Amount, Received, Percentage           98.00%            
Grant Amount Remaining, Percentage           2.00%            
National Institute of Aging Grant [Member] | Forecast [Member]                        
Government Assistance, Income, Increase (Decrease)               $ 6,200,000