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Note 10 - Stock-based Compensation Stock (Tables) | 12 Months Ended
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Dec. 31, 2025
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Research and development |  | $ | 482,669 |  |  | $ | 218,822 |
General and administrative |  |  | 965,965 |  |  |  | 1,186,900 |
Total stock-based compensation expense |  | $ | 1,448,634 |  |  | $ | 1,405,722 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual term (in years) |  |  | Aggregate intrinsic value |
Balance at January 1, 2025 |  |  | 636,802 |  |  | $ | 19.38 |  |  |  | 7.6 |  |  |  |  |
Granted |  |  | 466,600 |  |  | $ | 4.61 |  |  |  |  |  |  |  |  |
Expired |  |  | (68,367 | ) |  | $ | 45.84 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (42,334 | ) |  | $ | 8.22 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2025 |  |  | 992,701 |  |  | $ | 11.76 |  |  |  | 8.0 |  |  |  | — |
Exercisable at December 31, 2025 |  |  | 561,358 |  |  | $ | 15.92 |  |  |  | 7.2 |  |  |  | — |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Expected term (in years) |  | 5.24 | - | 5.76 |  |  | 5.25 | - | 5.76 |
Risk-free interest rate |  | 3.68 | - | 4.35 | % |  | 3.89 | - | 4.46 | %
Expected volatility |  | 71.55 | - | 76.68 | % |  | 76.06 | - | 80.03 | %
Dividend yield |  |  |  | — |  |  |  |  | — |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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