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Note 10 - Stock-based Compensation Stock (Tables)

12 Months Ended

Dec. 31, 2025

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Year Ended December 31,
		2025				2024
Research and development		$	482,669			$	218,822
General and administrative			965,965				1,186,900
Total stock-based compensation expense		$	1,448,634			$	1,405,722

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Options				Weighted average exercise price per share				Weighted average remaining contractual term (in years)				Aggregate intrinsic value
Balance at January 1, 2025			636,802			$	19.38				7.6
Granted			466,600			$	4.61
Expired			(68,367	)		$	45.84
Forfeited			(42,334	)		$	8.22
Outstanding at December 31, 2025			992,701			$	11.76				8.0				—
Exercisable at December 31, 2025			561,358			$	15.92				7.2				—

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		2025					2024
Expected term (in years)		5.24	-	5.76			5.25	-	5.76
Risk-free interest rate		3.68	-	4.35	%		3.89	-	4.46	%
Expected volatility		71.55	-	76.68	%		76.06	-	80.03	%
Dividend yield				—					—

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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- Definition

Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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