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Note 5 - Significant Agreements and Contracts (Details Textual) - USD ($)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Aug. 31, 2014
Mar. 31, 2025
Jun. 30, 2025
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Aug. 31, 2024
Jan. 31, 2023
Research and Development Expense       $ 21,817,072 $ 18,798,343      
Government Assistance, Asset       21,300,000        
Revenues       4,006,510 9,737,974      
Vertex Option and License Agreement [Member]                
Research and Development Expense $ 100,000              
Contractual Obligation $ 117,000,000              
Agreement, Milestone, Period for Net Sales 12 months              
Agreement, Maximum Deduction Percentage of Fees and Payments 50.00%              
Payments for License Agreement $ 100,000     0 0      
National Institute of Aging Grant [Member]                
Government Assistance, Asset             $ 300,000 $ 21,000,000
Government Assistance, Income, Increase (Decrease)       6,200,000 8,400,000 $ 6,700,000    
Revenues       4,000,000 9,700,000      
Proceeds From Grants       20,500,000        
Grant Funding Remaining       600,000        
Deferred Revenue, Current       $ 400,000 $ 2,300,000      
Grant Amount, Received, Percentage   90.00% 8.00%          
Grant Amount Remaining, Percentage       2.00%        
Grant Amount Canceled, Percentage       2.00%        
Grant Funding Canceled       $ 100,000