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Consolidated Statements of Convertible Preferred Shares and Shareholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Initial Public Offering | Series A Convertible Preferred Shares | Series B Convertible Preferred Shares | Common Shares | Common Shares Initial Public Offering | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ (22,384) |  |  |  | $ 1 |  | $ 340 | $ (22,725)
Temporary equity balance, Shares at Dec. 31, 2018 |  |  | 6,813,340 |  |  |  |  |
Temporary equity balance, Value at Dec. 31, 2018 |  |  | $ 31,873 |  |  |  |  |
Balance, Shares at Dec. 31, 2018 |  |  |  |  | 1,528,374 |  |  |
Issuance of convertible preferred shares, net of issuance costs |  |  | $ 21,876 | $ 82,248 |  |  |  |
Issuance of convertible preferred shares, net of issuance costs, Shares |  |  | 4,276,795 | 10,468,258 |  |  |  |
Series A Tranche 3 termination | 2,960 |  |  |  |  |  | 2,960 |
Share-based compensation expense | 511 |  |  |  |  |  | 511 |
Net loss and comprehensive loss | (27,216) |  |  |  |  |  |  | (27,216)
Balance at Dec. 31, 2019 | $ (46,129) |  |  |  | $ 1 |  | 3,811 | (49,941)
Temporary equity balance, Shares at Dec. 31, 2019 | 21,558,393 |  | 11,090,135 | 10,468,258 |  |  |  |
Temporary equity balance, Value at Dec. 31, 2019 | $ 135,997 |  | $ 53,749 | $ 82,248 |  |  |  |
Balance, Shares at Dec. 31, 2019 |  |  |  |  | 1,528,374 |  |  |
Exercise of vested stock options | $ 799 |  |  |  | $ 1,272 |  | (473) |
Exercise of common stock options, Shares | 416,157 |  |  |  | 416,157 |  |  |
Share-based compensation expense | $ 2,537 |  |  |  |  |  | 2,537 |
Issuance of common shares upon initial public offering, net of issuance costs |  | $ 232,043 |  |  |  | $ 232,043 |  |
Issuance of common shares upon initial public offering, net of issuance costs , Shares |  |  |  |  |  | 12,650,000 |  |
Conversion of convertible preferred shares into an equivalent number of common shares, Value | 135,997 |  | $ (53,749) | $ (82,248) | $ 135,997 |  |  |
Conversion of convertible preferred shares into an equivalent number of common shares, Shares |  |  | (11,090,135) | (10,468,258) | 21,558,393 |  |  |
Issuance of warrant and conversion into common shares,Value | 15,000 |  |  |  | $ 15,000 |  |  |
Issuance of warrant and conversion into common shares, Shares |  |  |  |  | 750,000 |  |  |
Net loss and comprehensive loss | (53,417) |  |  |  |  |  |  | (53,417)
Balance at Dec. 31, 2020 | $ 286,830 |  |  |  | $ 384,313 |  | $ 5,875 | $ (103,358)
Temporary equity balance, Shares at Dec. 31, 2020 |  |  | 0 | 0 |  |  |  |
Balance, Shares at Dec. 31, 2020 |  |  |  |  | 36,902,924 |  |  |

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