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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019
Cash Flows From Operating Activities: |  |
Net loss and comprehensive loss for the year | $ (53,417) | $ (27,216)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation expense | 2,537 | 511
Depreciation expense | 897 | 605
Change in fair value of Series A Preferred Shares tranche obligation |  | 1,350
Non-cash lease expense | 890 | 362
Foreign exchange (gain) loss | 588 | (629)
Deferred tax asset | (1,280) |
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (6,988) | (466)
Research and development tax credits receivable | (909) | (566)
Other receivables | (2,038) | (1,347)
Other non-current assets | 71 | (464)
Accounts payable | 17 | 833
Accrued expenses and other current liabilities | 4,573 | 611
Operating lease liabilities, current portion | (225) | 21
Income tax payable | (200) | 218
Operating lease liabilities, net of current portion | (465) | (394)
Deferred revenue | 49,865 | 8,142
Net cash used in operating activities | (6,084) | (18,429)
Cash Flows From Investing Activities: |  |
Purchase of property and equipment | (2,237) | (1,304)
Purchase of marketable securities | (7,526) |
Net cash used in investing activities | (9,763) | (1,304)
Cash Flows From Financing Activities: |  |
Proceeds from exercise of stock options | 799 |
Proceeds from issuance of warrant | 15,000 |
Net proceeds from issuance of common shares in initial public offering | 232,043 |
Net cash provided by financing activities | 247,842 | 103,243
Effect of exchange rate fluctuations on cash held | (604) | 566
Net Increase In Cash And Cash Equivalents And Restricted Cash | 231,391 | 84,076
Cash and cash equivalents and restricted cash at beginning of year | 95,005 | 10,929
Cash and cash equivalents and restricted cash at end of year | 326,396 | 95,005
Reconciliation Of Cash And Cash Equivalents And Restricted Cash |  |
Cash and cash equivalents | 326,184 | 94,797
Restricted cash | 212 | 208
Total cash and cash equivalents and restricted cash | 326,396 | 95,005
Supplemental Disclosure Of Cash Flow Information: |  |
Cash interest received | 216 |
Cash taxes paid | 156 | 23
Property and equipment purchases incurred but not yet paid | 218 | 40
Right-of-use assets obtained in exchange for new operating lease liability | 4,538 | 1,074
Conversion of Series A and B Preferred Shares into common shares | 135,997 |
Conversion of warrant into common shares | $ 15,000 |
Series A Preferred Shares |  |
Cash Flows From Financing Activities: |  |
Proceeds from issuance of preferred shares, net |  | 20,995
Series B Preferred Shares |  |
Cash Flows From Financing Activities: |  |
Proceeds from issuance of preferred shares, net |  | $ 82,248

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