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v3.22.0.1

Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Revenue: |  |  |
Collaboration agreements | $ 7,600 | $ 135 |
Operating expenses: |  |  |
Research and development, net of tax credits | 90,047 | 40,091 | $ 20,995
General and administrative | 26,213 | 14,346 | 5,382
Total operating expenses | 116,260 | 54,437 | 26,377
Loss from operations | (108,660) | (54,302) | (26,377)
Other (expense) income, net |  |  |
Realized and unrealized (loss) gain on foreign exchange | (144) | (664) | 712
Change in fair value of Series A Preferred Share tranche obligation |  |  | (1,350)
Interest income | 259 | 240 |
Other expense | (41) | (16) | (6)
Total other (expense) income, net | 74 | (440) | (644)
Loss before income taxes | (108,586) | (54,742) | (27,021)
Income tax benefit (expense) | 1,678 | 1,325 | (195)
Net loss and comprehensive loss | (106,908) | (53,417) | (27,216)
Net loss attributable to common shareholders—basic and diluted | $ (106,908) | $ (53,417) | $ (27,216)
Net loss per share attributable to common shareholders—basic and diluted | $ (2.83) | $ (2.66) | $ (17.81)
Weighted-average common shares outstanding—basic and diluted | 37,818,115 | 20,045,602 | 1,528,374

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