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Collaborations - Additional Information (Details)
¥ in Millions
1 Months Ended 10 Months Ended 12 Months Ended
May 26, 2020
USD ($)
Jan. 01, 2019
USD ($)
Jan. 01, 2019
JPY (¥)
Jun. 30, 2020
USD ($)
May 31, 2020
USD ($)
Oct. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Oct. 31, 2021
JPY (¥)
Jun. 23, 2020
shares
Jan. 01, 2019
JPY (¥)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Proceeds from issuance of warrant               $ 15,000,000        
Common Shares                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Shares issued upon exercise of warrants outstanding | shares                     750,000  
Collaboration and License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Non-refundable upfront payment received   $ 8,100,000         $ 8,100,000         ¥ 900
Initial nonrefundable upfront fee payment received   1,000,000.0 ¥ 110                  
Deferred revenue, additions   6,500,000 750                  
Milestone payments entitled to be received   3,900,000                   450
Research, Development and Regulatory Milestones | Collaboration and License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Initial nonrefundable upfront fee payment received   7,100,000 ¥ 790                  
Commercial Milestones | Collaboration and License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Milestone payments entitled to be received   $ 149,500,000                   ¥ 17,210
Ono Pharmaceutical Co., Ltd. | Collaboration and License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Collaboration term extended period           1 year            
Milestone payments entitled to be received           $ 900,000       ¥ 100    
Deferred revenue, current             9,000,000.0          
Deferred revenue, noncurrent               8,100,000        
Affiliate of Bristol Myers Squibb                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Proceeds from issuance of warrant $ 15,000,000.0       $ 15,000,000.0              
Affiliate of Bristol Myers Squibb | Common Shares                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Shares issued upon exercise of warrants outstanding | shares                     750,000  
Bristol-Myers Squibb Company                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Non-refundable upfront payment received               50,000,000        
Bristol-Myers Squibb Company | Collaboration and License Agreement                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Non-refundable upfront payment received         $ 50,000,000.0              
Initial nonrefundable upfront fee payment received       $ 50,000,000.0                
Revenue recognized             6,500,000 0 $ 0      
Collaboration term expiration period         42 months              
Deferred revenue recognized             1,100,000 100,000 $ 0      
Deferred revenue             42,500,000 49,900,000        
Deferred revenue, current             2,900,000 2,100,000        
Deferred revenue, noncurrent             $ 39,600,000 $ 47,800,000        
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Milestone payments entitled to be received         $ 301,000,000.0              
Bristol-Myers Squibb Company | Research, Development and Regulatory Milestones | Collaboration and License Agreement | Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Milestone payments entitled to be received         176,000,000.0              
Bristol-Myers Squibb Company | Commercial Milestones | Collaboration and License Agreement | Maximum                        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                        
Milestone payments entitled to be received         $ 125,000,000.0