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Condensed Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands | Total | 2020 Employee Share Purchase Plan | Common Shares | Common Shares 2020 Employee Share Purchase Plan | Additional Paid-in Capital | Additional Paid-in Capital 2020 Employee Share Purchase Plan | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2020 | $ 286,830 |  | $ 384,313 |  | $ 5,875 |  | $ (103,358)
Balance, Shares at Dec. 31, 2020 |  |  | 36,902,924 |  |  |  |
Exercise of stock options | 183 |  | $ 297 |  | (114) |  |
Exercise of stock options, Shares |  |  | 87,786 |  |  |  |
Share-based compensation expense | 2,057 |  |  |  | 2,057 |  |
Net loss and comprehensive loss | (21,417) |  |  |  |  |  | (21,417)
Balance at Mar. 31, 2021 | 267,653 |  | $ 384,610 |  | 7,818 |  | (124,775)
Balance, Shares at Mar. 31, 2021 |  |  | 36,990,710 |  |  |  |
Balance at Dec. 31, 2020 | 286,830 |  | $ 384,313 |  | 5,875 |  | (103,358)
Balance, Shares at Dec. 31, 2020 |  |  | 36,902,924 |  |  |  |
Net loss and comprehensive loss | (47,726) |  |  |  |  |  |
Balance at Jun. 30, 2021 | 245,089 |  | $ 385,454 |  | 10,719 |  | (151,084)
Balance, Shares at Jun. 30, 2021 |  |  | 37,109,506 |  |  |  |
Balance at Mar. 31, 2021 | 267,653 |  | $ 384,610 |  | 7,818 |  | (124,775)
Balance, Shares at Mar. 31, 2021 |  |  | 36,990,710 |  |  |  |
Exercise of stock options | 449 |  | $ 731 |  | (282) |  |
Exercise of stock options, Shares |  |  | 115,497 |  |  |  |
Share-based compensation expense | 3,183 |  |  |  | 3,183 |  |
Issuance of common shares | 113 |  | $ 113 |  |  |  |
Issuance of common shares, Shares |  |  | 3,299 |  |  |  |
Net loss and comprehensive loss | (26,309) |  |  |  |  |  | (26,309)
Balance at Jun. 30, 2021 | 245,089 |  | $ 385,454 |  | 10,719 |  | (151,084)
Balance, Shares at Jun. 30, 2021 |  |  | 37,109,506 |  |  |  |
Balance at Dec. 31, 2021 | 288,421 |  | $ 480,699 |  | 17,988 |  | (210,266)
Balance, Shares at Dec. 31, 2021 |  |  | 41,850,162 |  |  |  |
Exercise of stock options | 28 |  | $ 46 |  | (18) |  |
Exercise of stock options, Shares |  |  | 12,235 |  |  |  |
Share-based compensation expense | 4,755 |  |  |  | 4,755 |  |
Issuance of common shares under the 2020 Employee Share Purchase Plan |  | $ 213 |  | $ 303 |  | $ (90) |
Issuance of common shares under the 2020 Employee Share Purchase Plan, Shares |  |  |  | 16,807 |  |  |
Net loss and comprehensive loss | (34,757) |  |  |  |  |  | (34,757)
Balance at Mar. 31, 2022 | 258,660 |  | $ 481,048 |  | 22,635 |  | (245,023)
Balance, Shares at Mar. 31, 2022 |  |  | 41,879,204 |  |  |  |
Balance at Dec. 31, 2021 | $ 288,421 |  | $ 480,699 |  | 17,988 |  | (210,266)
Balance, Shares at Dec. 31, 2021 |  |  | 41,850,162 |  |  |  |
Exercise of stock options, Shares | 56,503 |  |  |  |  |  |
Net loss and comprehensive loss | $ (72,850) |  |  |  |  |  |
Balance at Jun. 30, 2022 | 225,517 |  | $ 481,380 |  | 27,253 |  | (283,116)
Balance, Shares at Jun. 30, 2022 |  |  | 41,923,472 |  |  |  |
Balance at Mar. 31, 2022 | 258,660 |  | $ 481,048 |  | 22,635 |  | (245,023)
Balance, Shares at Mar. 31, 2022 |  |  | 41,879,204 |  |  |  |
Exercise of stock options | 205 |  | $ 332 |  | (127) |  |
Exercise of stock options, Shares |  |  | 44,268 |  |  |  |
Share-based compensation expense | 4,745 |  |  |  | 4,745 |  |
Net loss and comprehensive loss | (38,093) |  |  |  |  |  | (38,093)
Balance at Jun. 30, 2022 | $ 225,517 |  | $ 481,380 |  | $ 27,253 |  | $ (283,116)
Balance, Shares at Jun. 30, 2022 |  |  | 41,923,472 |  |  |  |

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