XML 43 R34.htm IDEA: XBRL DOCUMENT
v3.25.2

Segment Information (Tables) | 6 Months Ended
--- | ---
Jun. 30, 2025
Segment Reporting [Abstract] |
Schedule of Reportable Segment Net Loss, Including Significant Expense Categories, Attributable to Company's Reportable Segment | The following table presents reportable segment net loss, including significant expense categories, attributable to the Company's reportable segment for the three and six months ended June 30, 2025 and 2024.
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
|  | (in thousands) |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreements |  | $ | 250 |  |  | $ | 1,073 |  |  | $ | 250 |  |  | $ | 53,477 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |
Discovery costs |  |  |  |  |  |  |  |  |  |  |  |
Direct external costs |  |  | 259 |  |  |  | 1,398 |  |  |  | 957 |  |  |  | 3,124 |
Laboratory supplies and research materials |  |  | 90 |  |  |  | 959 |  |  |  | 344 |  |  |  | 1,957 |
Personnel related costs |  |  | 243 |  |  |  | 3,232 |  |  |  | 1,750 |  |  |  | 6,418 |
Facilities related costs |  |  | 145 |  |  |  | 393 |  |  |  | 503 |  |  |  | 798 |
Other costs |  |  | 65 |  |  |  | 842 |  |  |  | 643 |  |  |  | 1,754 |
Development costs |  |  |  |  |  |  |  |  |  |  |  |
Direct external costs |  |  |  |  |  |  |  |  |  |  |  |
Camonsertib program |  |  | 1,848 |  |  |  | 3,961 |  |  |  | 4,114 |  |  |  | 7,941 |
Lunresertib program |  |  | 3,999 |  |  |  | 7,660 |  |  |  | 8,274 |  |  |  | 15,767 |
RP-1664 program |  |  | 1,579 |  |  |  | 1,412 |  |  |  | 2,921 |  |  |  | 3,008 |
RP-3467 and Polθ program |  |  | 1,541 |  |  |  | 773 |  |  |  | 2,638 |  |  |  | 2,328 |
Personnel related costs |  |  | 5,070 |  |  |  | 9,186 |  |  |  | 13,233 |  |  |  | 18,845 |
Facilities related costs |  |  | 233 |  |  |  | 213 |  |  |  | 480 |  |  |  | 421 |
Other costs |  |  | 695 |  |  |  | 1,186 |  |  |  | 1,584 |  |  |  | 2,618 |
Debiopharm development cost reimbursement |  |  | (1,413 | ) |  |  | (880 | ) |  |  | (2,682 | ) |  |  | (1,380 | )
R&D tax credits |  |  | (71 | ) |  |  | (260 | ) |  |  | (206 | ) |  |  | (554 | )
Total research and development costs |  | $ | 14,283 |  |  | $ | 30,075 |  |  | $ | 34,553 |  |  | $ | 63,045 |
Personnel related costs |  |  | 2,944 |  |  |  | 5,220 |  |  |  | 7,522 |  |  |  | 10,939 |
Other general administrative costs (1) |  |  | 3,085 |  |  |  | 3,097 |  |  |  | 6,159 |  |  |  | 5,996 |
Total general and administrative costs |  | $ | 6,029 |  |  | $ | 8,317 |  |  | $ | 13,681 |  |  | $ | 16,935 |
Restructuring costs |  |  | 3,384 |  |  |  | — |  |  |  | 6,649 |  |  |  | — |
Total operating expenses |  | $ | 23,696 |  |  | $ | 38,392 |  |  | $ | 54,883 |  |  | $ | 79,980 |
Gain on sale of technology and other assets |  |  | 5,666 |  |  |  | — |  |  |  | 5,666 |  |  |  | — |
Loss from operations |  | $ | (17,780 | ) |  | $ | (37,319 | ) |  | $ | (48,967 | ) |  | $ | (26,503 | )
Other income, net (2) |  |  | 1,284 |  |  |  | 2,871 |  |  |  | 2,798 |  |  |  | 5,846 |
Income tax expense |  |  | (248 | ) |  |  | (326 | ) |  |  | (618 | ) |  |  | (955 | )
Net loss |  | $ | (16,744 | ) |  | $ | (34,774 | ) |  | $ | (46,787 | ) |  | $ | (21,612 | )
(1) Includes professional fees, directors and officers insurance costs, public company operating costs, information technology related costs, and other administrative costs. (2) Includes interest income and other expenses.
Schedule of the Company's Revenue by Location | Revenue by location is as follows:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
|  | (in thousands) |
United States |  | $ | 250 |  |  | $ | — |  |  | $ | 250 |  |  | $ | 2,589 |
Switzerland |  |  | — |  |  |  | 1,073 |  |  |  | — |  |  |  | 50,888 |
Total revenue |  | $ | 250 |  |  | $ | 1,073 |  |  | $ | 250 |  |  | $ | 53,477 |
Schedule of Property and Equipment, Net and Right-of-Use Assets by Location | The Company’s property and equipment, net by country of domicile (Canada) and its subsidiary in the United States are as follows:
|  | As of June 30, |  |  | As of December 31, |
|  | 2025 |  |  | 2024 |
|  | (in thousands) |
Canada |  | $ | — |  |  | $ | 2,143 |
United States |  |  | 72 |  |  |  | 151 |
Total property and equipment, net |  | $ | 72 |  |  | $ | 2,294 |
The Company’s right-of-use assets by country of domicile (Canada) and its subsidiary in the United States are as follows:
|  | As of June 30, |  |  | As of December 31, |
|  | 2025 |  |  | 2024 |
|  | (in thousands) |
Canada |  | $ | 58 |  |  | $ | 891 |
United States |  |  | 571 |  |  |  | 1,033 |
Total right-of-use assets, net |  | $ | 629 |  |  | $ | 1,924 |

X
- Definition Tabular disclosure of long-lived assets, excluding financial instruments, long-term customer relationships of a financial institution, mortgage rights, deferred policy acquisition costs, and deferred tax assets, by geographic areas located in the entity's country of domicile and foreign countries in which the entity holds assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 41 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-41 + Details
Name: | us-gaap_LongLivedAssetsByGeographicAreasTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of revenue from external customers by geographic areas attributed to the entity's country of domicile and to foreign countries from which the entity derives revenue. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 41 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-41 + Details
Name: | us-gaap_RevenueFromExternalCustomersByGeographicAreasTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
Name: | us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_SegmentReportingAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration