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Segment Information - Schedule of Reportable Segment Net Loss, Including Significant Expense Categories Attributable to Company's Reportable Segment (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |
Collaboration agreements | $ 250 | $ 1,073 | $ 250 | $ 53,477
Operating expenses: |  |  |  |
Total research and development costs | 14,283 | 30,075 | 34,553 | 63,045
Total general and administrative costs | 6,029 | 8,317 | 13,681 | 16,935
Restructuring cost | 3,384 | 0 | 6,649 | 0
Total operating expenses | 23,696 | 38,392 | 54,883 | 79,980
Gain on sale of technology and other assets | 5,666 | 0 | 5,666 | 0
Loss from operations | (17,780) | (37,319) | (48,967) | (26,503)
Other income, net | 1,284 | 2,871 | 2,798 | 5,846
Income tax expense | (248) | (326) | (618) | (955)
Net loss | (16,744) | (34,774) | (46,787) | (21,612)
Operating Segments |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Collaboration agreements | 250 | 1,073 | 250 | 53,477
Operating expenses: |  |  |  |
Total research and development costs | 14,283 | 30,075 | 34,553 | 63,045
Personnel related costs | 2,944 | 5,220 | 7,522 | 10,939
Other general administrative costs | 3,085 | 3,097 | 6,159 | 5,996
Total general and administrative costs | 6,029 | 8,317 | 13,681 | 16,935
Restructuring cost | 3,384 | 0 | 6,649 | 0
Total operating expenses | 23,696 | 38,392 | 54,883 | 79,980
Gain on sale of technology and other assets | 5,666 | 0 | 5,666 | 0
Loss from operations | (17,780) | (37,319) | (48,967) | (26,503)
Other income, net | 1,284 | 2,871 | 2,798 | 5,846
Income tax expense | (248) | (326) | (618) | (955)
Net loss | (16,744) | (34,774) | (46,787) | (21,612)
Operating Segments | Discovery Costs |  |  |  |
Operating expenses: |  |  |  |
Direct external costs | 259 | 1,398 | 957 | 3,124
Laboratory supplies and research materials | 90 | 959 | 344 | 1,957
Personnel related costs | 243 | 3,232 | 1,750 | 6,418
Facilities related costs | 145 | 393 | 503 | 798
Other costs | 65 | 842 | 643 | 1,754
Operating Segments | Development Costs |  |  |  |
Operating expenses: |  |  |  |
Personnel related costs | 5,070 | 9,186 | 13,233 | 18,845
Facilities related costs | 233 | 213 | 480 | 421
Other costs | 695 | 1,186 | 1,584 | 2,618
Debiopharm development cost reimbursement | (1,413) | (880) | (2,682) | (1,380)
R&D tax credits | (71) | (260) | (206) | (554)
Operating Segments | Development Costs | Camonsertib Program |  |  |  |
Operating expenses: |  |  |  |
Direct external costs | 1,848 | 3,961 | 4,114 | 7,941
Operating Segments | Development Costs | Lunresertib Program |  |  |  |
Operating expenses: |  |  |  |
Direct external costs | 3,999 | 7,660 | 8,274 | 15,767
Operating Segments | Development Costs | RP-1664 Program |  |  |  |
Operating expenses: |  |  |  |
Direct external costs | 1,579 | 1,412 | 2,921 | 3,008
Operating Segments | Development Costs | RP-3467 and Pol Program |  |  |  |
Operating expenses: |  |  |  |
Direct external costs | $ 1,541 | $ 773 | $ 2,638 | $ 2,328

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