<SEC-DOCUMENT>0001104659-25-013687.txt : 20250214
<SEC-HEADER>0001104659-25-013687.hdr.sgml : 20250214
<ACCEPTANCE-DATETIME>20250214112334
ACCESSION NUMBER:		0001104659-25-013687
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250214
DATE AS OF CHANGE:		20250214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Repare Therapeutics Inc.
		CENTRAL INDEX KEY:			0001808158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			Z4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91542
		FILM NUMBER:		25625059

	BUSINESS ADDRESS:	
		STREET 1:		7171 FREDERICK BANTING
		STREET 2:		SUITE 270, BUILDING 2
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4S 1Z9
		BUSINESS PHONE:		(857) 412-7018

	MAIL ADDRESS:	
		STREET 1:		7171 FREDERICK BANTING
		STREET 2:		SUITE 270, BUILDING 2
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4S 1Z9

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARK Investment Management LLC
		CENTRAL INDEX KEY:			0001697748
		ORGANIZATION NAME:           	
		IRS NUMBER:				464309299
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		200 CENTRAL AVENUE
		CITY:			ST. PETERSBURG
		STATE:			FL
		ZIP:			33701
		BUSINESS PHONE:		212-426-7040

	MAIL ADDRESS:	
		STREET 1:		200 CENTRAL AVENUE
		CITY:			ST. PETERSBURG
		STATE:			FL
		ZIP:			33701
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001104659-22-016037</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: ARK Investment Management LLC -->
          <cik>0001697748</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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  <formData>
    <coverPageHeader>
      <amendmentNo>3</amendmentNo>
      <securitiesClassTitle>Common Shares, no par value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001808158</issuerCik>
        <issuerName>Repare Therapeutics Inc.</issuerName>
        <issuerCusip>760273102</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>7171 FREDERICK BANTING</com:street1>
          <com:street2>SUITE 270, BUILDING 2</com:street2>
          <com:city>SAINT-LAURENT, QUEBEC</com:city>
          <com:stateOrCountry>A8</com:stateOrCountry>
          <com:zipCode>1Z9</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
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      <reportingPersonName>ARK Investment Management LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1999996.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>1999996.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1999996.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.70</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
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    <items>
      <item1>
        <issuerName>Repare Therapeutics Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>7171 Frederick Banting Suite 270. Building 2, Saint-Laurent, A8, H4S 1Z9</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>ARK Investment Management LLC</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>200 Central Avenue, St. Petersburg, FL 33701</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Delaware</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>1,999,996</amountBeneficiallyOwned>
        <classPercent>4.70</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>1,999,996</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>1,999,996</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>To the knowledge of the Reporting Person, no other person has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, a number of the shares which represents more than five percent of the number of shares outstanding class of the shares.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
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      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
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      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>ARK Investment Management LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kellen Carter</signature>
        <title>Kellen Carter, Chief Compliance Officer</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
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</SEC-DOCUMENT>
