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Long-Term Investments (Details 4) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017
Net sales | $ 212,242 |  |  |
Gross Profit | 210,743 |  |  |
Net loss | (873,317) | (713,622) | (4,101,303) | (4,242,860)
Share of losses from investments accounted for using the equity method | (66,205) | (38,567) | (549) |
Rgene Corporation [Member] |  |  |  |
Net sales |  |  |  |
Gross Profit |  |  |  |
Net loss | (22,662) | (36,041) | (120,065) |
Share of losses from investments accounted for using the equity method |  |  | $ (549) |
BioFirst Corporation [Member] |  |  |  |
Net sales | 10,334 | 10,022 |  |
Gross Profit | 1,882 | 2,372 |  |
Net loss | (307,034) | (178,294) |  |
Share of losses from investments accounted for using the equity method | $ (66,205) | $ (38,567) |  |

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