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Related Parties Transactions (Details 5) - USD ($) | Mar. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | --- | ---
Due to related parties | $ 7,594,784 | $ 7,745,096 | $ 4,229,320
BioLite, Inc., [Member] |  |  |
Due to related parties |  | 58,684 | 109,220
BioFirst Corporation [Member] |  |  |
Due to related parties |  | 4,151,301 | 3,957,000
AsianGene Corporation [Member] |  |  |
Due to related parties |  | 160,000 | 160,000
YuanGene Corporation [Member] |  |  |
Due to related parties |  | 92,690 | 3,000
Eugene Jiang [Member] |  |  |
Due to related parties |  | $ 100 | $ 100

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