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Long-Term Investments (Details 4) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Net sales $ 212,242
Gross Profit 210,743
Net loss (873,317) (713,622) (4,101,303) (4,242,860)
Share of losses from investments accounted for using the equity method (66,205) (38,567) (549)
Rgene Corporation [Member]        
Net sales
Gross Profit
Net loss (22,662) (36,041) (120,065)
Share of losses from investments accounted for using the equity method $ (549)
BioFirst Corporation [Member]        
Net sales 10,334 10,022    
Gross Profit 1,882 2,372    
Net loss (307,034) (178,294)    
Share of losses from investments accounted for using the equity method $ (66,205) $ (38,567)