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Going Concern - Additional Information (Details) - USD ($)
 12 Months Ended
Feb. 23, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2022
Dec. 31, 2018
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Net loss   $ (29,199,000) $ (44,836,000) $ (39,612,000)    
Net cash used by operating activities   (18,811,000) (43,672,000) (31,951,000)    
Cash, cash equivalents, and restricted cash   14,421,000 18,289,000 60,038,000   $ 95,288,000
Restricted cash   499,000 393,000 $ 388,000    
Current liabilities   4,854,000 6,945,000      
Issuance of common stock   4,139,000 14,037,000      
Common stock, value   4,000 $ 4,000      
Shelf Registration Statement [Member] | ATM Facility [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Minimum public float   $ 75,000,000        
Maximum [Member] | Cellectis [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Threshold percentage of ownership in outstanding common stock to enact indemnification agreement   50.00%        
Subsequent Event [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Common stock, issued and sold 3,880,000          
Issuance of common stock $ 10,000,000.0          
After deduction of underwriting discounts and estimated other offering expenses $ 900,000          
Subsequent Event [Member] | Pre-funded Warrants [Member] | Maximum [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Warrants issued (in shares) 3,880,000          
Subsequent Event [Member] | Common Warrants [Member] | Maximum [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Warrants issued (in shares) 7,760,000          
Forecast [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Cash expense for separation-related payments         $ 500,000  
Equipment [Member]            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Restricted cash   $ 600,000