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STATEMENTS OF STOCKHOLDERS' EQUITY (UNAUDITED) - USD ($) | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit
--- | --- | --- | --- | ---
Balance, shares at Sep. 30, 2019 |  | 35,231,776 |  |
Balance, amount at Sep. 30, 2019 | $ 5,133,667 | $ 352,318 | $ 358,507,603 | $ (353,726,254)
Adoption of new accounting standard | 2,146,195 |  |  | 2,146,195
Issuance of common stock, shares |  | 606,395 |  |
Issuance of common stock, amount | 5,050,003 | $ 6,064 | 5,043,939 | 0
Warrant exercises, shares |  | 132,900 |  |
Warrant exercises, amount | 297,101 | $ 1,329 | 295,772 | 0
Equity based compensation - employees | 1,800,225 | $ 0 | 1,800,225 | 0
contributions paid in common stock, shares |  | 4,474 |  |
contributions paid in common stock, amount | 40,937 | $ 45 | 40,892 | 0
Stock issued to nonemployees for service, shares |  | 15,819 |  |
Stock issued to nonemployees for service, amount | 84,447 | $ 158 | 84,289 | 0
Purchase of stock by officer, shares |  | 3,725 |  |
Purchase of stock by officer, amount | 25,000 | $ 37 | 24,963 | 0
Share issuance costs | (92,150) | 0 | (92,150) | 0
Net loss | (5,531,360) | $ 0 | 0 | (5,531,360)
Balance, shares at Dec. 31, 2019 |  | 35,995,089 |  |
Balance, amount at Dec. 31, 2019 | 8,954,065 | $ 359,951 | 365,705,533 | (357,111,419)
Balance, shares at Sep. 30, 2019 |  | 35,231,776 |  |
Balance, amount at Sep. 30, 2019 | 5,133,667 | $ 352,318 | 358,507,603 | (353,726,254)
Net loss | (24,876,157) |  |  |
Balance, shares at Jun. 30, 2020 |  | 38,522,236 |  |
Balance, amount at Jun. 30, 2020 | 20,888,291 | $ 385,223 | 396,959,284 | (376,456,216)
Balance, shares at Dec. 31, 2019 |  | 35,995,089 |  |
Balance, amount at Dec. 31, 2019 | 8,954,065 | $ 359,951 | 365,705,533 | (357,111,419)
Warrant exercises, shares |  | 562,100 |  |
Warrant exercises, amount | 4,318,706 | $ 5,621 | 4,313,085 | 0
Equity based compensation - employees | 1,780,979 | $ 0 | 1,780,979 | 0
contributions paid in common stock, shares |  | 3,376 |  |
contributions paid in common stock, amount | 38,959 | $ 34 | 38,925 | 0
Stock issued to nonemployees for service, shares |  | 17,120 |  |
Stock issued to nonemployees for service, amount | 235,024 | $ 171 | 234,853 | 0
Share issuance costs | (199,372) | 0 | (199,372) | 0
Net loss | (9,067,818) | $ 0 | 0 | (9,067,818)
Proceeds from the sale of common stock, shares |  | 721,459 |  |
Proceeds from the sale of common stock, amount | 7,867,629 | $ 7,215 | 7,860,414 | 0
Purchase of stock by officers and directors, shares |  | 16,787 |  |
Purchase of stock by officers and directors, amount | 159,990 | $ 168 | 159,822 | 0
Option exercises, shares |  | 20,480 |  |
Option exercises, amount | 49,898 | $ 205 | 49,693 | 0
Balance, shares at Mar. 31, 2020 |  | 37,336,411 |  |
Balance, amount at Mar. 31, 2020 | 14,138,060 | $ 373,365 | 379,943,932 | (366,179,237)
Warrant exercises, shares |  | 849,845 |  |
Warrant exercises, amount | 10,156,275 | $ 8,498 | 10,147,777 | 0
Equity based compensation - employees | 3,109,127 | $ 0 | 3,109,127 | 0
contributions paid in common stock, shares |  | 2,875 |  |
contributions paid in common stock, amount | 42,895 | $ 29 | 42,866 | 0
Stock issued to nonemployees for service, shares |  | 14,811 |  |
Stock issued to nonemployees for service, amount | 205,381 | $ 148 | 205,233 | 0
Share issuance costs | (418,497) | 0 | (418,497) | 0
Net loss | (10,276,979) | $ 0 | 0 | (10,276,979)
Proceeds from the sale of common stock, shares |  | 94,575 |  |
Proceeds from the sale of common stock, amount | 1,074,807 | $ 946 | 1,073,861 | 0
Option exercises, shares |  | 73,719 |  |
Option exercises, amount | 276,415 | $ 737 | 275,678 | 0
Shares issued for settlement of clinical research costs, shares |  | 150,000 |  |
Shares issued for settlement of clinical research costs, amount | 1,769,500 | $ 1,500 | 1,768,000 | 0
Modification of warrants | 5,554 | 0 | 5,554 | 0
Warrant issuances | 805,753 | $ 0 | 805,753 | 0
Balance, shares at Jun. 30, 2020 |  | 38,522,236 |  |
Balance, amount at Jun. 30, 2020 | 20,888,291 | $ 385,223 | 396,959,284 | (376,456,216)
Balance, shares at Sep. 30, 2020 |  | 38,730,150 |  |
Balance, amount at Sep. 30, 2020 | 19,726,674 | $ 387,302 | 401,174,675 | (381,835,303)
Warrant exercises, shares |  | 15,000 |  |
Warrant exercises, amount | 89,250 | $ 150 | 89,100 | 0
Equity based compensation - employees | 3,296,309 | $ (20) | 3,296,329 | 0
contributions paid in common stock, shares |  | 3,564 |  |
contributions paid in common stock, amount | 41,671 | $ 36 | 41,635 | 0
Share issuance costs | (117,021) | 0 | (117,021) | 0
Net loss | (7,936,864) | $ 0 | 0 | (7,936,864)
Proceeds from the sale of common stock, shares |  | 1,000,000 |  |
Proceeds from the sale of common stock, amount | 13,559,500 | $ 10,000 | 13,549,500 | 0
Option exercises, shares |  | 5,300 |  |
Option exercises, amount | 23,511 | $ 53 | 23,458 | 0
Modification of warrants | 192 | $ 0 | 192 | 0
Equity based compensation - employees, shares |  | (2,000) |  |
Stock and options issued to nonemployees for service, shares |  | 15,044 |  |
Stock and options issued to nonemployees for service, amount | 152,450 | $ 150 | 152,300 | 0
Balance, shares at Dec. 31, 2020 |  | 39,767,058 |  |
Balance, amount at Dec. 31, 2020 | 28,835,672 | $ 397,671 | 418,210,168 | (389,772,167)
Balance, shares at Sep. 30, 2020 |  | 38,730,150 |  |
Balance, amount at Sep. 30, 2020 | 19,726,674 | $ 387,302 | 401,174,675 | (381,835,303)
Net loss | (28,156,252) |  |  |
Balance, shares at Jun. 30, 2021 |  | 42,963,391 |  |
Balance, amount at Jun. 30, 2021 | 59,793,744 | $ 429,634 | 469,355,665 | (409,991,555)
Balance, shares at Dec. 31, 2020 |  | 39,767,058 |  |
Balance, amount at Dec. 31, 2020 | 28,835,672 | $ 397,671 | 418,210,168 | (389,772,167)
Warrant exercises, shares |  | 991,239 |  |
Warrant exercises, amount | 7,938,841 | $ 9,912 | 7,928,929 | 0
Equity based compensation - employees | 3,282,742 | $ 0 | 3,282,742 | 0
contributions paid in common stock, shares |  | 3,347 |  |
contributions paid in common stock, amount | 51,420 | $ 33 | 51,387 | 0
Share issuance costs | (13,828) | 0 | (13,828) | 0
Net loss | (11,281,120) | $ 0 | 0 | (11,281,120)
Option exercises, shares |  | 48,845 |  |
Option exercises, amount | 138,788 | $ 489 | 138,299 | 0
Stock and options issued to nonemployees for service, shares |  | 13,486 |  |
Stock and options issued to nonemployees for service, amount | 379,277 | $ 135 | 379,142 | 0
Balance, shares at Mar. 31, 2021 |  | 40,823,975 |  |
Balance, amount at Mar. 31, 2021 | 29,331,792 | $ 408,240 | 429,976,839 | (401,053,287)
Warrant exercises, shares |  | 437,312 |  |
Warrant exercises, amount | 1,379,490 | $ 4,373 | 1,375,117 | 0
Equity based compensation - employees | 3,511,359 | $ 0 | 3,511,359 | 0
contributions paid in common stock, shares |  | 6,111 |  |
contributions paid in common stock, amount | 53,205 | $ 61 | 53,144 | 0
Share issuance costs | (103,185) | 0 | (103,185) | 0
Net loss | (8,938,268) | $ 0 | 0 | (8,938,268)
Proceeds from the sale of common stock, shares |  | 1,610,000 |  |
Proceeds from the sale of common stock, amount | 33,803,926 | $ 16,100 | 33,787,826 | 0
Option exercises, shares |  | 72,809 |  |
Option exercises, amount | 464,162 | $ 728 | 463,434 | 0
Modification of warrants | 24,195 | $ 0 | 24,195 | 0
Stock and options issued to nonemployees for service, shares |  | 13,184 |  |
Stock and options issued to nonemployees for service, amount | 267,068 | $ 132 | 266,936 | 0
Balance, shares at Jun. 30, 2021 |  | 42,963,391 |  |
Balance, amount at Jun. 30, 2021 | $ 59,793,744 | $ 429,634 | $ 469,355,665 | $ (409,991,555)

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