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Note 10 - Commitments and Contingencies (Details Textual) - USD ($) $ in Thousands |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Mar. 14, 2017 | Dec. 31, 2016 | Feb. 02, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating Leases, Rent Expense, Net |  |  |  | $ 136 | $ 33 | $ 12
Wanchun Biotech [Member] |  |  |  |  |  |
Quarterly Royalty Payments Required As a Percentage of Gross Proceeds on Sale of Product |  | 20.00% |  | 20.00% |  |
Term of Royalty Payments |  | 10 years |  |  |  |
Wanchun Biotech and Fortis Advisors LLC [Member] |  |  |  |  |  |
Period Following Royalty Termination Agreement, Requirement to Issue Shares |  |  | 3 years |  |  |
Percentage of Fully-diluted Equity Capitalization Required to Be Issued As Shares in Lieu of Royalty Payments |  |  | 10.00% |  |  |
Nereus Trust [Member] | Private Placement [Member] | Subsequent Event [Member] |  |  |  |  |  |
Stock Issued in Lieu of Royalty Payments | 2,112,963 |  |  |  |  |

X
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- Definition Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41499-112717 + Details
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