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Note 10 - Commitments and Contingencies (Details Textual) - USD ($) $ in Thousands				12 Months Ended
	Mar. 14, 2017	Dec. 31, 2016	Feb. 02, 2015	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Operating Leases, Rent Expense, Net				$ 136	$ 33	$ 12
Wanchun Biotech [Member]
Quarterly Royalty Payments Required As a Percentage of Gross Proceeds on Sale of Product		20.00%		20.00%
Term of Royalty Payments		10 years
Wanchun Biotech and Fortis Advisors LLC [Member]
Period Following Royalty Termination Agreement, Requirement to Issue Shares			3 years
Percentage of Fully-diluted Equity Capitalization Required to Be Issued As Shares in Lieu of Royalty Payments			10.00%
Nereus Trust [Member] | Private Placement [Member] | Subsequent Event [Member]
Stock Issued in Lieu of Royalty Payments	2,112,963

X

- Definition

The percent of the fully-diluted equity capitalization of the Company required to be issued as shares in lieu of royalty payments.

+ References

No definition available.

+ Details

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X

- Definition

The requirement to issue shares in lieu of royalty payments if the Company offers an IPO within this time frame.

+ References

No definition available.

+ Details

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X

- Definition

The percent of gross proceeds from the sale of product that is required to be paid out as royalties on a quarterly basis.

+ References

No definition available.

+ Details

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X

- Definition

The number of shares issued in lieu of royalty payments.

+ References

No definition available.

+ Details

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X

- Definition

The term in which royalty payments are due.

+ References

No definition available.

+ Details

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X

- Definition

Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 840
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41499-112717

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- Details

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