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Note 9 - Commitments and Contingencies (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 14, 2017
Feb. 02, 2015
Mar. 31, 2017
Mar. 31, 2016
Operating Leases, Rent Expense, Net     $ 43 $ 21
Research and Development Expenses Settled by Shares Issuance     $ 42,259
Shares Issued, Price Per Share $ 20      
Private Placement [Member] | Nereus Trust [Member]        
Stock Issued in Lieu of Royalty Payments 2,112,963      
Wanchun Biotech [Member]        
Quarterly Royalty Payments Required As a Percentage of Gross Proceeds on Sale of Product     20.00%  
Term of Royalty Payments     10 years  
Wanchun Biotech and Fortis Advisors LLC [Member]        
Period Following Royalty Termination Agreement, Requirement to Issue Shares   3 years    
Percentage of Fully-diluted Equity Capitalization Required to Be Issued As Shares in Lieu of Royalty Payments   10.00%