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Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue | $ 0 | $ 0 | $ 0
Operating expenses: |  |  |
Research and development, including patent cost of $42,259 for the year ended December 31, 2017 | (88,928) | (10,437) | (6,282)
General and administrative | (9,053) | (1,931) | (1,193)
Loss from operations | (97,981) | (12,368) | (7,475)
Foreign exchange gain (loss), net | 555 | (195) | 13
Interest income | 120 | 18 | 13
Other income | 918 |  |
Interest expense |  |  | (532)
Loss on disposal of property and equipment |  |  | (27)
Net loss on equity method investment |  |  | (44)
Net loss before income tax | (96,388) | (12,545) | (8,052)
Income tax benefit |  |  |
Net loss | (96,388) | (12,545) | (8,052)
Less: Net loss attributable to noncontrolling interests | (4,625) | (535) | (82)
Net loss attributable to BeyondSpring Inc. | $ (91,763) | $ (12,010) | $ (7,970)
Net loss per share |  |  |
Basic and diluted (in dollars per share) | $ (4.40) | $ (0.75) | $ (0.53)
Weighted average shares outstanding |  |  |
Basic and diluted (in shares) | 20,866,084 | 16,086,419 | 15,171,370
Other comprehensive loss |  |  |
Foreign currency translation adjustment loss | $ 1 | $ 64 | $ 21
Total comprehensive loss | (96,389) | (12,609) | (8,073)
Less: Comprehensive loss attributable to noncontrolling interests | (4,535) | (561) | (92)
Comprehensive loss attributable to BeyondSpring Inc. | $ (91,854) | $ (12,048) | $ (7,981)

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