<SEC-DOCUMENT>0001140361-20-026325.txt : 20201123
<SEC-HEADER>0001140361-20-026325.hdr.sgml : 20201123
<ACCEPTANCE-DATETIME>20201123161648
ACCESSION NUMBER:		0001140361-20-026325
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20201123
FILED AS OF DATE:		20201123
DATE AS OF CHANGE:		20201123

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BeyondSpring Inc.
		CENTRAL INDEX KEY:			0001677940
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				463009483
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38024
		FILM NUMBER:		201337511

	BUSINESS ADDRESS:	
		STREET 1:		28 LIBERTY STREET
		STREET 2:		39TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005
		BUSINESS PHONE:		646-528-4184

	MAIL ADDRESS:	
		STREET 1:		28 LIBERTY STREET
		STREET 2:		39TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>nt10017010x4_6k.htm
<DESCRIPTION>FORM 6-K
<TEXT>
<html>
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      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center"><font style="background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-style: normal; font-variant: normal; text-transform: none;">UNITED STATES</font></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SECURITIES AND
      EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">WASHINGTON, D.C.
      20549</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">FORM 6-K</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER</div>
    <div style="text-align: center; font-weight: bold;">PURSUANT TO RULE 13a-16 OR 15d-16</div>
    <div style="text-align: center; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">For the month of November, 2020</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Commission File Number: 001-38024</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">BeyondSpring
      Inc.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">BeyondSpring Inc.</div>
    <div style="text-align: center; font-weight: bold;">28 Liberty Street, 39th Floor</div>
    <div style="text-align: center; font-weight: bold;">New York, New York 10005</div>
    <div style="text-align: center; font-weight: bold;">(Address of principal executive office)</div>
    <div><br>
    </div>
    <div>Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.</div>
    <div><br>
    </div>
    <div>Form 20-F&#160;&#160; &#9746;&#160;&#160;&#160;&#160; Form 40-F&#160;&#160; &#9744;</div>
    <div><br>
    </div>
    <div>Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): &#9744;</div>
    <div><br>
    </div>
    <div>Note: Regulation S-T Rule 101(b)(1) only permits the submission in paper of a Form 6-K if submitted solely to provide an attached annual report to security holders.</div>
    <div><br>
    </div>
    <div>Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): &#9744;</div>
    <div><br>
    </div>
    <div>Note: Regulation S-T Rule 101(b)(7) only permits the submission in paper of a Form 6-K if submitted to furnish a report or other document that the registrant foreign private issuer must furnish and make public under the laws of the jurisdiction in
      which the registrant is incorporated, domiciled or legally organized (the registrant&#8217;s &#8220;home country&#8221;), or under the rules of the home country exchange on which the registrant&#8217;s securities are traded, as long as the report or other document is not a
      press release, is not required to be and has not been distributed to the registrant&#8217;s security holders, and, if discussing a material event, has already been the subject of a Form 6-K submission or other Commission filing on EDGAR.</div>
    <div>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div><br>
    </div>
    <div>&#160;</div>
    <div>On November 18, 2020, BeyondSpring Inc. (the &#8220;Company&#8221;) entered into an Underwriting Agreement (the &#8220;Underwriting Agreement&#8221;) with BofA Securities, Inc., Jefferies LLC and Evercore Group L.L.C., as representatives of the underwriters named therein
      (the &#8220;Underwriters&#8221;), relating to an offering (the &#8220;Offering&#8221;) of an aggregate of 8,625,000 ordinary shares of the Company, par value $0.0001 per share (the &#8220;Ordinary Shares&#8221;), including the exercise in full of the Underwriters&#8217; option to purchase an
      additional 1,125,000 Ordinary Shares, at the public offering price of $10.00 per share. The Offering closed on November 23, 2020. The gross proceeds from the Offering will be approximately $86.1 million, before deducting underwriting discounts and
      commissions and other offering expenses.</div>
    <div><br>
    </div>
    <div>The Offering was made pursuant to the Company&#8217;s effective shelf registration statement on Form F-3 (File No. 333-249816), including the prospectus dated November 12, 2020, as supplemented by the prospectus supplement dated November 18, 2020.</div>
    <div><br>
    </div>
    <div>A copy of the Underwriting Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the Underwriting Agreement does not purport to be complete and is qualified in its entirety by reference
      to such exhibit.</div>
    <div><br>
    </div>
    <div>A copy of the opinion of Maples and Calder (Hong Kong) LLP relating to the validity of the securities to be issued pursuant to the Underwriting Agreement is filed herewith as Exhibit 5.1.</div>
    <div><br>
    </div>
    <div>The information contained in this report is hereby incorporated by reference into the Registration Statement on Form F-3 (File No. 333-249816) and Registration Statement on Form S-8 (File No. 333-240082).</div>
    <div><br>
    </div>
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    <div><br>
    </div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div>Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="ze07296f84ca446ffa99e9c661cd7d6ea" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td colspan="3" style="vertical-align: top;">
            <div>BeyondSpring Inc.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 4%; vertical-align: top; padding-bottom: 2px;">
            <div>By:</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Lan Huang</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">
            <div>Name:</div>
          </td>
          <td style="width: 40%; vertical-align: top;">
            <div>Lan Huang</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">
            <div>Title:</div>
          </td>
          <td style="width: 40%; vertical-align: top;">
            <div>Chairman and Chief Executive Officer</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>Date: November 23, 2020</div>
    <div><br>
    </div>
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    <div><br>
    </div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">EXHIBIT INDEX</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6740bbddd7574781b537825ad4a35ecd" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 14.13%; vertical-align: top;">
            <div style="font-weight: bold;"><u>Exhibit No.</u></div>
          </td>
          <td style="width: 85.87%; vertical-align: top;">
            <div style="font-weight: bold;"><u>Exhibit</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">&#160;</td>
          <td style="width: 85.87%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">
            <div><a href="nt10017010x4_ex1-1.htm">1.1</a></div>
          </td>
          <td style="width: 85.87%; vertical-align: top;">
            <div>Underwriting Agreement, dated as of November 18, 2020, by and between the Company, BofA Securities, Inc., Jefferies LLC and Evercore Group L.L.C., as representatives of the underwriters named therein.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">&#160;</td>
          <td style="width: 85.87%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">
            <div><a href="nt10017010x4_ex5-1.htm">5.1</a></div>
          </td>
          <td style="width: 85.87%; vertical-align: top;">
            <div>Opinion of Maples and Calder (Hong Kong) LLP.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">&#160;</td>
          <td style="width: 85.87%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 14.13%; vertical-align: top;">
            <div><a href="nt10017010x4_ex5-1.htm">23.1</a></div>
          </td>
          <td style="width: 85.87%; vertical-align: top;">
            <div>Consent of Maples and Calder (Hong Kong) LLP (included in Exhibit 5.1).</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>nt10017010x4_ex1-1.htm
<DESCRIPTION>EXHIBIT 1.1
<TEXT>
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    <div>
      <div style="text-align: right; font-weight: bold;">Exhibit 1.1</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">BeyondSpring Inc.</div>
      <div style="text-align: center; font-weight: bold;">7,500,000 Ordinary Shares</div>
      <div style="text-align: center; font-weight: bold;">(Par Value $0.0001 Per Share)</div>
      <div style="text-align: center; font-weight: bold;"><u>UNDERWRITING AGREEMENT</u></div>
      <div><br>
      </div>
      <div style="text-align: right;">November 18, 2020</div>
      <div><br>
      </div>
      <div>BOFA SECURITIES, INC.</div>
      <div>JEFFERIES LLC</div>
      <div>EVERCORE GROUP L.L.C.</div>
      <div>As Representatives of the several Underwriters</div>
      <div><br>
      </div>
      <div>c/o BOFA SECURITIES, INC.</div>
      <div>One Bryant Park</div>
      <div>New York, New York 10036</div>
      <div><br>
      </div>
      <div>c/o JEFFERIES LLC</div>
      <div>520 Madison Avenue</div>
      <div>New York, New York 10022</div>
      <div><br>
      </div>
      <div>c/o EVERCORE GROUP L.L.C.</div>
      <div>55 East 52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street</div>
      <div>New York, New York 10055</div>
      <div><br>
      </div>
      <div>Ladies and Gentlemen:</div>
      <div><br>
      </div>
      <div><font style="font-weight: bold;">Introductory.</font>&#160; BeyondSpring Inc., a Cayman Island exempted company (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;), proposes to issue and sell to the several underwriters named in <u>Schedule A</u>
        (the &#8220;<font style="font-weight: bold;">Underwriters</font>&#8221;) an aggregate of 7,500,000 ordinary shares, par value $0.0001 per share (the &#8220;<font style="font-weight: bold;">Ordinary Shares</font>&#8221;), of the Company (the &#8220;<font style="font-weight: bold;">Firm Shares</font>&#8221;).&#160; In addition, the Company has granted to the Underwriters an option to purchase up to an additional 1,125,000 Ordinary Shares as provided in Section 2 (the &#8220;<font style="font-weight: bold;">Optional Shares</font>&#8221;).&#160;
        The Firm Shares and, if and to the extent such option is exercised, the Optional Shares are collectively called the &#8220;<font style="font-weight: bold;">Offered Shares</font>.&#8221;&#160; BofA Securities, Inc. (&#8220;<font style="font-weight: bold;">BofA</font>&#8221;),
        Jefferies LLC (&#8220;<font style="font-weight: bold;">Jefferies</font>&#8221;) and Evercore Group L.L.C. (&#8220;<font style="font-weight: bold;">Evercore</font>&#8221;) have agreed to act as representatives of the several Underwriters (in such capacity, the &#8220;<font style="font-weight: bold;">Representatives</font>&#8221;) in connection with the offering and sale of the Offered Shares. To the extent there are no additional underwriters listed on <u>Schedule A</u>, the term &#8220;Representatives&#8221; as used herein shall
        mean you, as Underwriters, and the term &#8220;Underwriters&#8221; shall mean either the singular or the plural, as the context requires.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The Company has prepared and filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold;">Commission</font>&#8221;) a shelf registration statement on Form F-3, File No. 333&#8209;249816 with respect to
        the Ordinary Shares, including a base prospectus (the &#8220;<font style="font-weight: bold;">Base Prospectus</font>&#8221;) to be used in connection with the public offering and sale of the Offered Shares.&#160; Such registration statement, as amended, including
        the financial statements, exhibits and schedules thereto, in the form in which it became effective under the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder (collectively, the &#8220;<font style="font-weight: bold;">Securities Act</font>&#8221;), including all documents incorporated or deemed to be incorporated by reference therein and any information deemed to be a part thereof at the time of effectiveness pursuant to Rule 430A or 430B under the Securities
        Act, is called the &#8220;<font style="font-weight: bold;">Registration Statement</font>.&#8221;&#160; Any registration statement filed by the Company pursuant to Rule 462(b) under the Securities Act in connection with the offer and sale of the Offered Shares is
        called the &#8220;<font style="font-weight: bold;">Rule 462(b) Registration Statement</font>,&#8221; and from and after the date and time of filing of any such Rule 462(b) Registration Statement the term &#8220;Registration Statement&#8221; shall include the Rule 462(b)
        Registration Statement.&#160; The preliminary prospectus supplement dated November 17, 2020 describing the Offered Shares and the offering thereof (the &#8220;<font style="font-weight: bold;">Preliminary Prospectus Supplement</font>&#8221;), together with the Base
        Prospectus, is called the &#8220;<font style="font-weight: bold;">Preliminary Prospectus</font>,&#8221; and the Preliminary Prospectus and any other prospectus supplement to the Base Prospectus in preliminary form that describes the Offered Shares and the
        offering thereof and is used prior to the filing of the Prospectus (as defined below), together with the Base Prospectus, is called a</div>
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      <!--PROfilePageNumberReset%Num%2%%%-->
      <div>&#160;&#8220;<font style="font-weight: bold;">preliminary prospectus</font>.&#8221;&#160; As used herein, the term &#8220;<font style="font-weight: bold;">Prospectus</font>&#8221; shall mean the final prospectus supplement to the Base Prospectus that describes the Offered Shares
        and the offering thereof (the &#8220;<font style="font-weight: bold;">Final Prospectus Supplement</font>&#8221;), together with the Base Prospectus, in the form first used by the Underwriters to confirm sales of the Offered Shares<font style="font-weight: bold;">&#160;</font>or in the form first made available to the Underwriters by the Company to meet requests of purchasers pursuant to Rule 173 under the Securities Act.&#160; References herein to the Preliminary Prospectus, any preliminary prospectus and
        the Prospectus shall refer to both the prospectus supplement and the Base Prospectus components of such prospectus.&#160; As used herein, &#8220;<font style="font-weight: bold;">Applicable Time</font>&#8221; is 7:00 p.m. (New York City time) on November 18, 2020.&#160;
        As used herein, &#8220;<font style="font-weight: bold;">free writing prospectus</font>&#8221; has the meaning set forth in Rule 405 under the Securities Act, and &#8220;<font style="font-weight: bold;">Time of Sale Prospectus</font>&#8221; means the Preliminary
        Prospectus, as amended or supplemented immediately prior to the Applicable Time, together with the free writing prospectuses, if any, and pricing information identified in <u>Schedule B</u> hereto.&#160; As used herein, <font style="font-weight: bold;">&#8220;Road Show&#8221;</font> means a &#8220;road show&#8221; (as defined in Rule 433 under the Securities Act) relating to the offering of the Offered Shares contemplated hereby that is a &#8220;written communication&#8221; (as defined in Rule 405 under the Securities
        Act).&#160; As used herein, &#8220;<font style="font-weight: bold;">Section 5(d) Written Communication</font>&#8221; means each written communication (within the meaning of Rule 405 under the Securities Act) that is made in reliance on Section 5(d) of the
        Securities Act by the Company or any person authorized to act on behalf of the Company to one or more potential investors that are qualified institutional buyers (&#8220;<font style="font-weight: bold;">QIBs</font>&#8221;) and/or institutions that are
        accredited investors (&#8220;<font style="font-weight: bold;">IAIs</font>&#8221;), as such terms are respectively defined in Rule 144A and Rule 501(a) under the Securities Act, to determine whether such investors might have an interest in the offering of the
        Offered Shares; &#8220;<font style="font-weight: bold;">Section 5(d) Oral Communication</font>&#8221; means each oral communication, if any, made in reliance on Section 5(d) of the Securities Act by the Company or any person authorized to act on behalf of the
        Company made to one or more QIBs and/or one or more IAIs to determine whether such investors might have an interest in the offering of the Offered Shares; &#8220;<font style="font-weight: bold;">Marketing Materials</font>&#8221; means any materials or
        information provided to investors by, or with the approval of, the Company in connection with the marketing of the offering of the Offered Shares, including any roadshow or investor presentations made to investors by the Company (whether in person
        or electronically); and &#8220;<font style="font-weight: bold;">Permitted Section 5(d) Communication</font>&#8221; means the Section 5(d) Written Communication(s) and Marketing Materials listed on Schedule C attached hereto.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">All references in this Agreement to the Registration Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus and the Prospectus shall include the documents incorporated or deemed to be
        incorporated by reference therein.&#160; All references in this Agreement to financial statements and schedules and other information which are &#8220;contained,&#8221; &#8220;included&#8221; or &#8220;stated&#8221; in, or &#8220;part of&#8221; the Registration Statement, the Rule 462(b) Registration
        Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus, the Time of Sale Prospectus or the Prospectus, and all other references of like import, shall be deemed to mean and include all such financial statements and
        schedules and other information which is or is deemed to be incorporated by reference in the Registration Statement, the Rule 462(b) Registration Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus, the Time of
        Sale Prospectus or the Prospectus, as the case may be.&#160; All references in this Agreement to amendments or supplements to the Registration Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus, the Time of Sale
        Prospectus or the Prospectus shall be deemed to mean and include the filing of any document under the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder (collectively, the &#8220;<font style="font-weight: bold;">Exchange Act</font>&#8221;) that is or is deemed to be incorporated by reference in the Registration Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus, or the Prospectus, as the case may be.&#160; All references
        in this Agreement to (i) the Registration Statement, the Preliminary Prospectus, any preliminary prospectus, the Base Prospectus or the Prospectus, any amendments or supplements to any of the foregoing, or any free writing prospectus, shall include
        any copy thereof filed with the Commission pursuant to its Electronic Data Gathering, Analysis and Retrieval System (&#8220;<font style="font-weight: bold;">EDGAR</font>&#8221;) and (ii) the Prospectus shall be deemed to include any &#8220;electronic Prospectus&#8221;
        provided for use in connection with the offering of the Offered Shares as contemplated by Section 3(n) of this Agreement.</div>
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      <div style="text-indent: 36pt;">The Company hereby confirms its agreement with the Underwriters as follows:</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 1.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Representations and Warranties of the Company.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">A.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Representations and Warranties of the Company</font><font style="font-weight: bold;">.</font>&#160; The Company hereby
        represents, warrants and covenants to each Underwriter, as of the date of this Agreement, as of the First Closing Date (as hereinafter defined) and as of each Option Closing Date (as hereinafter defined), if any, as follows:</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Compliance with Registration Requirements</font><font style="font-weight: bold;">.</font>&#160; The Registration
        Statement has become effective under the Securities Act.&#160; The Company has complied, to the Commission&#8217;s satisfaction, with all requests of the Commission for additional or supplemental information, if any.&#160; No stop order suspending the
        effectiveness of the Registration Statement is in effect and no proceedings for such purpose have been instituted or are pending or, to the best knowledge of the Company, are contemplated or threatened by the Commission.&#160; At the time the Company&#8217;s
        Annual Report on Form 20-F for the year ended December 30, 2019 (the &#8220;<font style="font-weight: bold;">Annual Report</font>&#8221;) was filed with the Commission, or, if later, at the time the Registration Statement was originally filed with the
        Commission, the Company met the then-applicable requirements for use of Form F-3 under the Securities Act.&#160; The Company is a &#8220;foreign private issuer&#8221; within the meaning of Rule 405 under the Act.&#160; The documents incorporated or deemed to be
        incorporated by reference in the Registration Statement, the Time of Sale Prospectus and the Prospectus, at the time they were or hereafter are filed with the Commission, or became effective under the Exchange Act, as the case may be, complied and
        will comply in all material respects with the requirements of the Exchange Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Disclosure</font><font style="font-weight: bold;">.</font>&#160; Each preliminary prospectus and the Prospectus when
        filed complied in all material respects with the Securities Act and, if filed by electronic transmission pursuant to EDGAR, was identical (except as may be permitted by Regulation S&#8209;T under the Securities Act) to the copy thereof delivered to the
        Underwriters for use in connection with the offer and sale of the Offered Shares.&#160; Each of the Registration Statement and any post-effective amendment thereto, at the time it became or becomes effective, complied and will comply in all material
        respects with the Securities Act and did not and will not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading.&#160; As of the
        Applicable Time, the Time of Sale Prospectus did not, and at the First Closing Date (as defined in Section 2) and at each applicable Option Closing Date (as defined in Section 2), will not, contain any untrue statement of a material fact or omit to
        state a material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading.&#160; The Prospectus, as of its date, did not, and at the First Closing Date and at each applicable Option
        Closing Date, will not, contain any untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.&#160; The
        representations and warranties set forth in the three immediately preceding sentences do not apply to statements in or omissions from the Registration Statement or any post-effective amendment thereto, or the Prospectus or the Time of Sale
        Prospectus, or any amendments or supplements thereto, made in reliance upon and in conformity with written information relating to any Underwriter furnished to the Company in writing by the Representatives expressly for use therein, it being
        understood and agreed that the only such information consists of the information described in Section 9(b) below.&#160; There are no contracts or other documents required to be described in the Time of Sale Prospectus or the Prospectus or to be filed as
        an exhibit to the Registration Statement which have not been described or filed as required.</div>
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      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Free Writing Prospectuses; Road Show</font><font style="font-weight: bold;">.</font>&#160; As of the determination
        date referenced in Rule 164(h) under the Securities Act, the Company was not, is not or will not be (as applicable) an &#8220;ineligible issuer&#8221; in connection with the offering of the Offered Shares pursuant to Rules 164, 405 and 433 under the Securities
        Act.&#160; Each free writing prospectus that the Company is required to file pursuant to Rule 433(d) under the Securities Act has been, or will be, filed with the Commission in accordance with the requirements of the Securities Act.&#160; Each free writing
        prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) under the Securities Act or that was prepared by or on behalf of or used or referred to by the Company complies or will comply in all material respects with the
        requirements of Rule 433 under the Securities Act, including timely filing with the Commission, retention and legending, as applicable, and each such free writing prospectus, as of its issue date and at all subsequent times through the completion
        of the public offer and sale of the Offered Shares did not, does not and will not include any information that conflicted, conflicts or will conflict with the information contained in the Registration Statement, the Prospectus or any preliminary
        prospectus unless such information has been superseded or modified as of such time.&#160; Except for the free writing prospectuses, if any, and pricing information identified in <u>Schedule B</u>, and electronic road shows, if any, furnished to you
        before first use, the Company has not prepared, used or referred to, and will not, without your prior consent, prepare, use or refer to, any free writing prospectus.&#160; Each Road Show, when considered together with the Time of Sale Prospectus, did
        not, as of the Applicable Time, contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Distribution of Offering Material By the Company</font><font style="font-weight: bold;">.</font>&#160; Prior to the
        later of (i) the expiration or termination of the option granted to the several Underwriters in Section 2, and (ii) the completion of the Underwriters&#8217; distribution of the Offered Shares, the Company has not distributed and will not distribute any
        offering material in connection with the offering and sale of the Offered Shares other than the Registration Statement, the Time of Sale Prospectus, the Prospectus or any free writing prospectus reviewed and consented to by the Representatives, the
        free writing prospectuses, if any, and pricing information identified on <u>Schedule B</u> hereto and any Permitted Section 5(d) Communications.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">The Underwriting Agreement</font><font style="font-weight: bold;">.</font>&#160; This Agreement has been duly
        authorized, executed and delivered by the Company.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Authorization of the Offered Shares</font><font style="font-weight: bold;">.</font>&#160; &#160; The Offered Shares have
        been duly authorized for issuance and sale pursuant to this Agreement and, when issued by the Company against payment therefor pursuant to this Agreement, will be validly issued, fully paid and non-assessable, and the issuance and sale of the
        Offered Shares is not subject to any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase the Offered Shares.&#160; Upon the issuance to the Underwriters of the Offered Shares, and payment therefor, the
        Underwriters will acquire good, marketable and valid title to such Offered Shares, free and clear of all pledges, liens, security interests, charges, claims or encumbrances.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Applicable Registration or Other Similar Rights</font><font style="font-weight: bold;">.</font>&#160; There are no
        persons with registration or other similar rights to have any equity or debt securities registered for sale under the Registration Statement or included in the offering contemplated by this Agreement, except for such rights as have been duly
        waived.</div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Material Adverse Change</font><font style="font-weight: bold;">.</font>&#160; Except as otherwise disclosed in the
        Registration Statement, the Time of Sale Prospectus and the Prospectus, subsequent to the respective dates as of which information is given in the Registration Statement, the Time of Sale Prospectus and the Prospectus: (i) there has been no
        material adverse change, or any development that could reasonably be expected to result in a material adverse change, in (A) the condition, financial or otherwise, or in the earnings, business, operations or prospects, whether or not arising from
        transactions in the ordinary course of business, of the Company and its subsidiaries, considered as one entity or (B) the ability of the Company to consummate the transactions contemplated by this Agreement or perform its obligations hereunder (any
        such change being referred to herein as a &#8220;<font style="font-weight: bold;">Material Adverse Change</font>&#8221;); (ii) the Company and its subsidiaries, considered as one entity, have not incurred any material liability or obligation, indirect, direct
        or contingent, not in the ordinary course of business nor entered into any material transaction or agreement not in the ordinary course of business; and (iii) there has been no dividend or distribution of any kind declared, paid or made by the
        Company or, except for dividends paid to the Company or other subsidiaries, by any of the Company&#8217;s subsidiaries on any class of share capital, or any repurchase or redemption by the Company or any of its subsidiaries of any class of share capital.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Statistical and Market-Related Data</font><font style="font-weight: bold;">.</font>&#160; The statistical,
        demographic and market&#8209;related data included in the Registration Statement, the Time of Sale Prospectus or the Prospectus are based on or derived from sources that the Company believes to be reliable and accurate or represent the Company&#8217;s good
        faith estimates that are made on the basis of data derived from such sources.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(j)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Independent Accountants</font><font style="font-weight: bold;">.</font>&#160; Ernst &amp; Young Hua Ming LLP, which
        has expressed its opinion with respect to the financial statements (which term as used in this Agreement includes the related notes thereto) filed with the Commission as a part of the Registration Statement, the Time of Sale Prospectus and the
        Prospectus, is (i) an independent registered public accounting firm as required by the Securities Act, the Exchange Act, (ii) in compliance with the applicable requirements relating to the qualification of accountants under Rule 2-01 of Regulation
        S-X under the Securities Act and (iii) a registered public accounting firm as defined by the Public Company Accounting Oversight Board (&#8220;<font style="font-weight: bold;">PCAOB</font>&#8221;) whose registration has not been suspended or revoked and who
        has not requested such registration to be withdrawn.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(k)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Financial Statements</font><font style="font-weight: bold;">.</font>&#160; The financial statements filed with the
        Commission as a part of the Registration Statement, the Time of Sale Prospectus and the Prospectus present fairly the consolidated financial position of the Company and its subsidiaries as of and at the dates indicated and the results of their
        operations and cash flows for the periods specified.&#160; Such financial statements have been prepared in conformity with generally accepted accounting principles as applied in the United States applied on a consistent basis throughout the periods
        involved, except as may be expressly stated in the related notes thereto.&#160; The interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement fairly presents the information called for
        in all material respects and has been prepared in accordance with the Commission&#8217;s rules and guidelines applicable thereto. No other financial statements or supporting schedules are required to be included in the Registration Statement, the Time of
        Sale Prospectus or the Prospectus.&#160; The financial data set forth or incorporated by reference in each of the Registration Statement, the Time of Sale Prospectus and the Prospectus under the captions &#8220;Selected Financial Data&#8221; and &#8220;Capitalization&#8221;
        fairly present the information set forth therein on a basis consistent with that of the audited financial statements contained in the Registration Statement, the Time of Sale Prospectus and the Prospectus. To the Company&#8217;s knowledge, no person who
        has been suspended or barred from being associated with a registered public accounting firm, or who has failed to comply with any sanction pursuant to Rule 5300 promulgated by the PCAOB, has participated in or otherwise aided the preparation of, or
        audited, the financial statements, supporting schedules or other financial data filed with the Commission as a part of the Registration Statement, the Time of Sale Prospectus and the Prospectus.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">5</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(l)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Company&#8217;s Accounting System</font><font style="font-weight: bold;">.</font>&#160; The Company and each of its
        subsidiaries make and keep accurate books and records and maintain a system of internal accounting controls sufficient to provide reasonable assurance that: (i) transactions are executed in accordance with management&#8217;s general or specific
        authorization; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles as applied in the United States and to maintain accountability for assets; (iii)
        access to assets is permitted only in accordance with management&#8217;s general or specific authorization; (iv) the recorded accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect
        to any differences; and (v) the interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement, the Time of Sale Prospectus and the Prospectus fairly presents the information called
        for in all material respects and is prepared in accordance with the Commission&#8217;s rules and guidelines applicable thereto.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(m)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Disclosure Controls and Procedures; Deficiencies in or Changes to Internal Control Over Financial Reporting</font><font style="font-weight: bold;">.</font> The Company has established and maintains disclosure controls and procedures (as defined in Rules 13a-15 and 15d-15 under the Exchange Act), which (i) are designed to ensure that material information relating
        to the Company, including its consolidated subsidiaries, is made known to the Company&#8217;s principal executive officer and its principal financial officer by others within those entities, particularly during the periods in which the periodic reports
        required under the Exchange Act are being prepared; (ii) have been evaluated by management of the Company for effectiveness as of the end of the Company&#8217;s most recent fiscal quarter; and (iii) are effective in all material respects to perform the
        functions for which they were established.&#160; Based on the most recent evaluation of its disclosure controls and procedures, the Company is not aware of (i) any significant deficiencies or material weaknesses in the design or operation of internal
        control over financial reporting which are reasonably likely to adversely affect the Company&#8217;s ability to record, process, summarize and report financial information; or (ii) any fraud, whether or not material, that involves management or other
        employees who have a significant role in the Company&#8217;s internal control over financial reporting, in each case except as would not result in a Material Adverse Change.&#160; The Company is not aware of any change in its internal control over financial
        reporting that has occurred during its most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the Company&#8217;s internal control over financial reporting.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(n)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Incorporation and Good Standing of the Company</font><font style="font-weight: bold;">.</font>&#160; The Company has
        been duly incorporated and is validly existing as an exempted company in good standing under the laws of the Cayman Islands and has the power and authority (corporate or other) to own, lease and operate its properties and to conduct its business as
        described in the Registration Statement, the Time of Sale Prospectus and the Prospectus and to enter into and perform its obligations under this Agreement.&#160; The Company is duly qualified as a foreign corporation to transact business and is in good
        standing in each jurisdiction in which such qualification is required, whether by reason of the ownership or leasing of property or the conduct of business except as would not result in a Material Adverse Change.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(o)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Subsidiaries</font><font style="font-weight: bold;">.</font>&#160; Each of the Company&#8217;s &#8220;subsidiaries&#8221; (for purposes
        of this Agreement, as defined in Rule 405 under the Securities Act) has been duly incorporated or organized, as the case may be, and is validly existing as a corporation, partnership or limited liability company, as applicable, in good standing
        under the laws of the jurisdiction of its incorporation or organization and has the power and authority (corporate or other) to own, lease and operate its properties and to conduct its business as described in the Registration Statement, the Time
        of Sale Prospectus and the Prospectus. Each of the Company&#8217;s subsidiaries is duly qualified as a foreign corporation, partnership or limited liability company, as applicable, to transact business and is in good standing in each jurisdiction in
        which such qualification is required, whether by reason of the ownership or leasing of property or the conduct of business except as would not result in a Material Adverse Change. All of the issued and outstanding share capital or other equity or
        ownership interests of each of the Company&#8217;s subsidiaries have been duly authorized and validly issued, are fully paid and nonassessable and are owned by the Company, directly or through subsidiaries, free and clear of any security interest,
        mortgage, pledge, lien, encumbrance or adverse claim, except with respect to the unpaid paid-in capital of Dalian Wanchunbulin Pharmaceuticals Ltd., the unpaid paid-in capital of Wanchun Biotechnology (Shenzhen) Ltd. and the unpaid paid-in capital
        of Beijing Wanchun Pharmaceuticals Technology Ltd.&#160; The Company does not own or control, directly or indirectly, any corporation, association or other entity other than (i) the subsidiaries listed on Exhibit 8.1 to the Company&#8217;s most recent annual
        report on Form 20-F and (ii) such other entities omitted from Exhibit 8.1 which, when such omitted entities are considered in the aggregate as a single subsidiary, would not constitute a significant subsidiary within the meaning of Rule 1-02(w) of
        Regulation S-X.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">6</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(p)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Capitalization and Other Share Capital Matters</font><font style="font-weight: bold;">.</font>&#160; The authorized,
        issued and outstanding share capital of the Company is as set forth in the Registration Statement, the Time of Sale Prospectus and the Prospectus under the captions &#8220;Description of Share Capital&#8221; and &#8220;Capitalization&#8221; (other than for subsequent
        issuances, if any, pursuant to employee benefit plans described in the Prospectus, or upon the exercise of outstanding options described in the Registration Statement, the Time of Sale Prospectus and the Prospectus).&#160; The Ordinary Shares of the
        Company, including the Offered Shares, conform in all material respects to the description thereof contained in the Time of Sale Prospectus.&#160; All of the issued and outstanding Ordinary Shares have been duly authorized and validly issued, are fully
        paid and non-assessable and have been issued in compliance with federal and state securities laws, except with respect to the unpaid paid-in capital of Dalian Wanchunbulin Pharmaceuticals Ltd., the unpaid paid-in capital of Wanchun Biotechnology
        (Shenzhen) Ltd. and the unpaid paid-in capital of Beijing Wanchun Pharmaceuticals Technology Ltd. and, except as otherwise set forth in the Registration Statement, the Time of Sale Prospectus and the Prospectus.&#160; None of the issued and outstanding
        Ordinary Shares were issued in violation of any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase securities of the Company.&#160; There are no authorized or outstanding options, warrants, preemptive rights,
        rights of first refusal or other rights to purchase, or equity or debt securities convertible into or exchangeable or exercisable for, any share capital of the Company or capital stock of any of its subsidiaries other than those accurately
        described in the Registration Statement, the Time of Sale Prospectus and the Prospectus.&#160; The description of the Company&#8217;s share option, share bonus and other share plans or arrangements, and the options or other rights granted thereunder, set
        forth in the Registration Statement, the Time of Sale Prospectus and the Prospectus accurately and fairly presents the information required to be shown with respect to such plans, arrangements, options and rights.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(q)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Stock Exchange Listing</font><font style="font-weight: bold;">.</font>&#160; The Offered Shares are registered
        pursuant to Section 12(b) of the Exchange Act and are listed on the Nasdaq Capital Market (the &#8220;<font style="font-weight: bold;">Nasdaq</font>&#8221;), and the Company has taken no action designed to, or likely to have the effect of, terminating the
        registration of the Offered Shares under the Exchange Act or delisting the Offered Shares from the Nasdaq, nor has the Company received any notification that the Commission or the Nasdaq is contemplating terminating such registration or listing. To
        the Company&#8217;s knowledge, it is in compliance with all applicable listing requirements of the Nasdaq.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(r)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Non-Contravention of Existing Instruments; No Further Authorizations or Approvals Required</font><font style="font-weight: bold;">.</font>&#160; Neither the Company nor any of its subsidiaries is in violation of its charter or by&#8209;laws, partnership agreement or operating agreement or similar organizational document, as applicable, or is in default (or,
        with the giving of notice or lapse of time, would be in default) (&#8220;<font style="font-weight: bold;">Default</font>&#8221;) under any indenture, mortgage, loan or credit agreement, note, contract, franchise, lease or other instrument to which the Company
        or any of its subsidiaries is a party or by which it or any of them may be bound (including, without limitation, any credit agreement, indenture, pledge agreement, securities agreement or other instrument or agreement evidencing, guaranteeing,
        securing or relating to indebtedness of the Company or any of its subsidiaries), or to which any of property or assets of the Company or any of its subsidiaries is subject (each, an &#8220;<font style="font-weight: bold;">Existing Instrument</font>&#8221;),
        except for such Defaults as would not, individually or in the aggregate, result in a Material Adverse Change.&#160; The Company&#8217;s execution, delivery and performance of this Agreement, consummation of the transactions contemplated hereby and by the
        Registration Statement, the Time of Sale Prospectus and the Prospectus and the issuance and sale of the Offered Shares (including the use of proceeds from the sale of the Offered Shares as described in the Registration Statement, the Time of Sale
        Prospectus and the Prospectus under the caption &#8220;Use of Proceeds&#8221;) (i) have been duly authorized by all necessary corporate action and will not result in any violation of the provisions of the charter or by&#8209;laws, partnership agreement or operating
        agreement or similar organizational document of the Company or any subsidiary, as applicable; (ii) will not conflict with or constitute a breach of, or Default under, or result in the creation or imposition of any lien, charge or encumbrance upon
        any property or assets of the Company or any of its subsidiaries pursuant to, or require the consent of any other party to, any Existing Instrument; and (iii) will not result in any violation of any law, administrative regulation or administrative
        or court decree applicable to the Company or any of its subsidiaries.&#160; No consent, approval, authorization or other order of, or registration or filing with, any court or other governmental or regulatory authority or agency, is required for the
        Company&#8217;s execution, delivery and performance of this Agreement and consummation of the transactions contemplated hereby, and by the Registration Statement, the Time of Sale Prospectus and the Prospectus, other than such as have been obtained or
        made by the Company and are in full force and effect under the Securities Act and such as may be required under applicable state securities or blue sky laws or Financial Industry Regulatory Authority, Inc. (&#8220;<font style="font-weight: bold;">FINRA</font>&#8221;).</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">7</font></div>
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      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(s)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Compliance with Laws.</font>&#160; The Company and its subsidiaries have been and are in compliance with all
        applicable laws, rules and regulations, except where failure to be so in compliance could not be expected, individually or in the aggregate, to result in a Material Adverse Change.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(t)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Material Actions or Proceedings</font><font style="font-weight: bold;">.</font>&#160; Except as otherwise
        disclosed in the Prospectus, there are no legal or governmental actions, suits or proceedings pending or, to the best of the Company&#8217;s knowledge, threatened (i) against or affecting the Company or any of its subsidiaries; (ii) which have as the
        subject thereof any officer or director of, or property owned or leased by, the Company or any of its subsidiaries; or (iii) relating to environmental or discrimination matters, where in any such case (A) there is a reasonable possibility that such
        action, suit or proceeding might be determined adversely to the Company, such subsidiary or such officer or director, (B) any such action, suit or proceeding, if so determined adversely, would reasonably be expected to result in a Material Adverse
        Change or adversely affect the consummation of the transactions contemplated by this Agreement or (C) any such action, suit or proceeding is or would be material in the context of the sale of Shares.&#160; Except as otherwise disclosed in the
        Prospectus, no material labor dispute with the employees of the Company or any of its subsidiaries, or with the employees of any principal supplier, manufacturer, customer or contractor of the Company, exists or, to the best of the Company&#8217;s
        knowledge, is threatened or imminent.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(u)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Intellectual Property Rights</font><font style="font-weight: bold;">. </font>Except as otherwise disclosed in
        the Prospectus, to the Company&#8217;s knowledge, the Company and its subsidiaries own, possess, license or have other rights to use, on reasonable terms, all patents, patent applications, trade and service marks, trade and service mark registrations,
        trade names, copyrights, licenses, inventions, trade secrets, technology, know-how and other intellectual property (collectively, the &#8220;<font style="font-weight: bold;">Intellectual Property</font>&#8221;) necessary for the conduct of the Company&#8217;s
        business as now conducted or as proposed in the Prospectus to be conducted. Except as set forth in the Prospectus, (a) to the Company&#8217;s knowledge, there are no exclusive rights of third parties to any such Intellectual Property; (b) to the
        Company&#8217;s knowledge, there is no material infringement by third parties of any such Intellectual Property; (c) there is no pending or, to the Company&#8217;s knowledge, threatened action, suit, proceeding or claim by others, challenging the Company&#8217;s
        rights in or to any such Intellectual Property, and the Company is unaware of any facts which would form a reasonable basis for any such claim; (d) there is no material pending or, to the Company&#8217;s knowledge, threatened action, suit, proceeding or
        claim by others challenging the validity or scope of any such Intellectual Property; (e) there is no pending or, to the Company&#8217;s knowledge, threatened action, suit, proceeding or claim by others that the Company infringes or otherwise violates any
        patent, trademark, copyright, trade secret or other proprietary rights of others, and the Company is unaware of any other fact which would form a reasonable basis for any such claim; (f) to the Company&#8217;s knowledge, there is no U.S. patent or
        published U.S. patent application which contains claims that dominate or may dominate any Intellectual Property described in the Prospectus as being owned by or licensed to the Company or that interferes with the issued or pending claims of any
        such Intellectual Property; and (g) there is no prior art of which the Company is aware that may render any U.S. patent held by the Company invalid or any non-provisional U.S. patent application held by the Company unpatentable which has not been
        disclosed to or cited by the U.S. Patent and Trademark Office during the pendency of such patents and applications.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">8</font></div>
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      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(v)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">All Necessary Permits, etc</font><font style="font-weight: bold;">.</font>&#160; Except as otherwise disclosed in the
        Prospectus, the Company and each subsidiary possess such valid and current certificates, authorizations or permits issued by the appropriate state, federal or foreign regulatory agencies or bodies necessary for the ownership or lease of its
        properties or the conduct of its businesses as described in the Registration, Statement and the Prospectus, or to permit all clinical and nonclinical studies and trials conducted by or on behalf of the Company and its subsidiaries, including,
        without limitation, all necessary U.S. Food and Drug Administration (the &#8220;<font style="font-weight: bold;">FDA</font>&#8221;), National Medical Products Administration (the &#8220;<font style="font-weight: bold;">NMPA</font>&#8221;) and applicable foreign regulatory
        agency approvals&#894; and neither the Company nor any subsidiary has received, or has any reason to believe that it will receive, any notice of proceedings relating to the revocation or modification of, or non-compliance with, any such certificate,
        authorization or permit which, singly or in the aggregate, if the subject of an unfavorable decision, ruling or finding, could result in a Material Adverse Change.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(w)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Title to Properties</font><font style="font-weight: bold;">.</font>&#160; Except as otherwise disclosed in the
        Prospectus, the Company and each of its subsidiaries has good and marketable title to all of the real and personal property and other assets reflected as owned in the financial statements referred to in Section 1(k) above, in each case free and
        clear of any security interests, mortgages, liens, encumbrances, equities, adverse claims and other defects, except such as do not materially and adversely affect the value of such property and do not materially interfere with the use made or
        proposed to be made of such property by the Company or such subsidiary.&#160; The real property, improvements, equipment and personal property held under lease by the Company or any subsidiary are held under valid and enforceable leases, with such
        exceptions as are not material and do not materially interfere with the use made or proposed to be made of such real property, improvements, equipment or personal property by the Company or such subsidiary.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(x)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Tax Law Compliance</font><font style="font-weight: bold;">.</font>&#160; The Company has filed all tax returns that
        are required to be filed or has requested extensions thereof (except in any case in which the failure to so file would not individually or in the aggregate, reasonably be expected to have a Material Adverse Change), except as set forth in or
        contemplated in the Prospectus and has paid all taxes required to be paid by it and any other assessment, fine or penalty levied against it, to the extent that any of the foregoing is due and payable, except for any such assessment, fine or penalty
        that is currently being contested in good faith or as would not individually or in the aggregate, reasonably be expected to have a Material Adverse Change, except as set forth in or contemplated in the Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(y)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Company Not an &#8220;Investment Company&#8221;.</font>&#160; The Company has been advised of the rules and requirements under
        the Investment Company Act of 1940, as amended (the &#8220;Investment Company Act&#8221;).&#160; The Company is not, and will not be, either after receipt of payment for the Offered Shares or after the application of the proceeds therefrom as described under &#8220;Use
        of Proceeds&#8221; in the Prospectus, an &#8220;investment company&#8221; within the meaning of Investment Company Act and will conduct its business in a manner so that it will not become subject to the Investment Company Act.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">9</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(z)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Insurance</font><font style="font-weight: bold;">.</font>&#160; Except as otherwise disclosed in the Prospectus, each
        of the Company and its subsidiaries are insured by recognized, financially sound and reputable institutions with policies in such amounts and with such deductibles and covering such risks as are generally deemed adequate and customary for their
        businesses including, but not limited to, policies covering real and personal property owned or leased by the Company and its subsidiaries against theft, damage, destruction, acts of vandalism and earthquakes and policies covering the Company and
        its subsidiaries for product liability claims and clinical trial liability claims.&#160; The Company has no reason to believe that it or any subsidiary will not be able (i) to renew its existing insurance coverage as and when such policies expire; or
        (ii) to obtain comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that would not result in a Material Adverse Change.&#160; Neither the Company nor any subsidiary has
        been denied any insurance coverage which it has sought or for which it has applied.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(aa)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Price Stabilization or Manipulation; Compliance with Regulation M</font>.&#160; The Company has not taken,
        directly or indirectly, any action designed to or that might be reasonably expected to cause or result in stabilization or manipulation of the price of the Ordinary Shares or any other &#8220;reference security&#8221; (as defined in Rule 100 of Regulation M
        under the Exchange Act (&#8220;<font style="font-weight: bold;">Regulation M</font>&#8221;)) whether to facilitate the sale or resale of the Offered Shares or otherwise, and has taken no action which would directly or indirectly violate Regulation M.&#160; The
        Company acknowledges that the Underwriters may engage in passive market making transactions in the Shares on the Nasdaq in accordance with Regulation M.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(bb)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Related Party Transactions</font>.&#160; There are no business relationships or related-party transactions involving
        the Company or any of its subsidiaries or any other person required to be described in the Prospectus which have not been described as required.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(cc)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">FINRA Matters.</font>&#160; If applicable, all of the information provided to the Underwriters or to counsel for the
        Underwriters by the Company, its officers and directors and the holders of any securities (debt or equity) or options to acquire any securities of the Company in connection with letters, filings or other supplemental information provided to FINRA
        pursuant to FINRA Rules 5110, 5190 and 5121 is true, complete and correct.&#160; Neither the Company nor any of its Affiliates directly, or indirectly through one or more intermediaries, controls, or is controlled by, or is under common control with, or
        is a person associated with any member firm of FINRA.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(dd)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Unlawful Contributions or Other Payments.</font>&#160; Except as otherwise disclosed in the Prospectus, neither
        the Company nor any of its subsidiaries nor, to the best of the Company&#8217;s knowledge, any employee or agent of the Company or any subsidiary, has made any contribution or other payment to any official of, or candidate for, any federal, state or
        foreign office in violation of any law or of the character required to be disclosed in the Registration Statement and the Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ee)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Compliance with Environmental Laws</font><font style="font-weight: bold;">.&#160; </font>Except as described in the
        Prospectus and except as would not, singly or in the aggregate, result in a Material Adverse Change, (i) neither the Company nor any of its subsidiaries is in violation of any federal, state, local or foreign statute, law, rule, regulation,
        ordinance, code, policy or rule of common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the
        environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release or threatened release of chemicals,
        pollutants, contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products (collectively, &#8220;<font style="font-weight: bold;">Hazardous Materials</font>&#8221;) or to the manufacture, processing, distribution, use, treatment,
        storage, disposal, transport or handling of Hazardous Materials (collectively, &#8220;<font style="font-weight: bold;">Environmental Laws</font>&#8221;), (ii) the Company and its subsidiaries have all permits, authorizations and approvals required under any
        applicable Environmental Laws and are each in compliance with their requirements, (iii) there are no pending or threatened administrative, regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of noncompliance or
        violation, investigation or proceedings relating to any Environmental Law against the Company or any of its subsidiaries and (iv) there are no events or circumstances that might reasonably be expected to form the basis of an order for clean-up or
        remediation, or an action, suit or proceeding by any private party or governmental body or agency, against or affecting the Company or any of its subsidiaries relating to Hazardous Materials or any Environmental Laws.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">10</font></div>
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      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ff)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Periodic Review of Costs of Environmental Compliance</font><font style="font-weight: bold;">.</font>&#160; In the
        ordinary course of its business, the Company conducts a periodic review of the effect of Environmental Laws on the business, operations and properties of the Company and its subsidiaries, in the course of which it identifies and evaluates
        associated costs and liabilities (including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws or any permit, license or approval, any related constraints on
        operating activities and any potential liabilities to third parties).&#160; On the basis of such review and the amount of its established reserves, the Company has reasonably concluded that such associated costs and liabilities would not, individually
        or in the aggregate, result in a Material Adverse Change.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(gg)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">ERISA Compliance</font><font style="font-weight: bold;">.&#160; </font>Except as would not reasonably be expected
        to have a Material Adverse Change, none of the following events has occurred or exists: (i) a failure to fulfill the obligations, if any, under the minimum funding standards of Section 302 of the United States Employee Retirement Income Security
        Act of 1974, as amended, and the regulations and published interpretations thereunder (&#8220;<font style="font-weight: bold;">ERISA</font>&#8221;), with respect to any Plan (as defined below), determined without regard to any waiver of such obligations or
        extension of any amortization period; (ii) an audit or investigation by the Internal Revenue Service, the U.S. Department of Labor, the Pension Benefit Guaranty Corporation or any other federal or state governmental agency or any foreign regulatory
        agency with respect to the employment or compensation of employees by any of the Company or any of its subsidiaries; (iii) any breach of any contractual obligation, or any violation of law or applicable qualification standards, with respect to the
        employment or compensation of employees by the Company or any of its subsidiaries; (iv) an increase in the aggregate amount of contributions required to be made to all Plans in the current fiscal year of the Company and its subsidiaries compared to
        the amount of such contributions made in the most recently completed fiscal year of the Company and its subsidiaries; (v) an increase in the &#8220;accumulated post-retirement benefit obligations&#8221; (within the meaning of Statement of Financial Accounting
        Standards 106) of the Company and its subsidiaries compared to the amount of such obligations in the most recently completed fiscal year of the Company and its subsidiaries; (vi) any event or condition giving rise to a liability under Title IV of
        ERISA; or (vii) the filing of a claim by one or more employees or former employees of the Company or any of its subsidiaries related to their employment.&#160; For purposes of this paragraph, the term &#8220;<font style="font-weight: bold;">Plan</font>&#8221; means
        a plan (within the meaning of Section 3(3) of ERISA) subject to Title IV of ERISA with respect to which the Company or any of its subsidiaries would reasonably be expected to have any material liability.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(hh)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Parties to Lock-Up Agreements</font><font style="font-weight: bold;">.</font>&#160; The Company has furnished to the
        Underwriters a letter agreement in the form attached hereto as <u>Exhibit F</u> (the &#8220;<font style="font-weight: bold;">Lock-up Agreement</font>&#8221;) from each of the persons or entities listed on <u>Exhibit G</u>.&#160; Such <u>Exhibit G</u> lists under
        an appropriate caption certain shareholders, the directors and executive officers of the Company.&#160; If any additional persons shall become directors or executive officers of the Company prior to the end of the Company Lock-up Period (as defined
        below), the Company shall cause each such person, prior to or contemporaneously with their appointment or election as a director or executive officer of the Company, to execute and deliver to the Representatives a Lock-up Agreement.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">11</font></div>
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      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Compliance with Laws.</font><font style="font-weight: bold;">&#160; </font>Except as otherwise disclosed in the
        Prospectus, based on the Company&#8217;s reasonable belief, the Company and each of its subsidiaries: (A) is and at all times has been in compliance in all material respects with all statutes, rules, or regulations applicable to the ownership, testing,
        development, manufacture, packaging, processing, use, distribution, labeling, storage, import, export or disposal of any product manufactured or distributed by the Company, including, without limitation the U.S. Food, Drug and Cosmetic Act, the
        regulations promulgated pursuant to such laws, including without limitation, regulations relating to Good Clinical Practices and Good Laboratory Practices and all other local, state, federal, national, supranational and foreign laws and regulations
        relating to the regulation of the Company (&#8220;<font style="font-weight: bold;">Applicable Laws</font>&#8221;), except for such non-compliance as would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Change&#894; (B)
        has not received any FDA Form 483, notice of adverse finding, warning letter, untitled letter or other correspondence or notice from the FDA or any other court, arbitrator or governmental authority alleging or asserting any material noncompliance
        with any Applicable Laws or any licenses, certificates, approvals, clearances, authorizations, permits and supplements or amendments thereto required by any such Applicable Laws (&#8220;<font style="font-weight: bold;">Authorizations</font>&#8221;), except for
        such non-compliance as would not, individually or in the aggregate, have a Material Adverse Change&#894; (C) possesses all material Authorizations and such Authorizations are valid and in full force and effect and are not in violation of any material
        term of any such Authorizations&#894; (D) has not received notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any governmental authority or third party alleging that any product operation
        or activity is in violation of any Applicable Laws or Authorizations and to the knowledge of the Company, no such proceeding has been threatened by such governmental authority&#894; (E) has not received any written notice that any governmental authority
        has taken, is taking or will take action to materially limit, suspend, modify or revoke any Authorizations and to the knowledge of the Company, no such proceeding has been threatened by any such governmental authority&#894; and (F) has filed, obtained,
        maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required by any Applicable Laws or Authorizations and that all such reports, documents, forms,
        notices, applications, records, claims, submissions and supplements or amendments were complete and correct on the date filed (or were corrected or supplemented by a subsequent submission).</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(jj)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Dividend Restrictions.</font><font style="font-weight: bold;">&#160; </font>Except as disclosed in the Prospectus,
        no subsidiary of the Company is prohibited or restricted, directly or indirectly, from paying dividends to the Company, or from making any other distribution with respect to such subsidiary&#8217;s equity securities or from repaying to the Company or any
        other subsidiary of the Company any amounts that may from time to time become due under any loans or advances to such subsidiary from the Company or from transferring any property or assets to the Company or to any other subsidiary.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(kk)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Foreign Corrupt Practices Act.</font><font style="font-weight: bold;">&#160; </font>Neither the Company nor any of
        its subsidiaries nor, to the knowledge of the Company, any director, officer, agent, employee, affiliate or other person acting on behalf of the Company or any of its subsidiaries is aware of or has taken any action, directly or indirectly, that
        could result in a violation or a sanction for violation by such persons of the Foreign Corrupt Practices Act of 1977 or the U.K. Bribery Act 2010, each as may be amended, or similar law of any other relevant jurisdiction, or the rules or
        regulations thereunder; and the Company and its subsidiaries have instituted and maintain policies and procedures to ensure compliance therewith. No part of the proceeds of the offering will be used, directly or indirectly, in violation of the
        Foreign Corrupt Practices Act of 1977 or the U.K. Bribery Act 2010, each as may be amended, or similar law of any other relevant jurisdiction, or the rules or regulations thereunder.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">12</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ll)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Money Laundering Laws.</font><font style="font-weight: bold;">&#160; </font>The operations of the Company and its
        subsidiaries are, and have been conducted at all times, in compliance with applicable financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money laundering statutes of
        all applicable jurisdictions, the rules and regulations thereunder and any related or similar applicable rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the &#8220;<font style="font-weight: bold;">Money Laundering Laws</font>&#8221;) and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any of its subsidiaries with respect to the Money Laundering Laws
        is pending or, to the best knowledge of the Company, threatened.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(mm)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Clinical Studies</font>. All preclinical studies and clinical trials conducted by or on behalf of the Company
        that are material to the Company and its subsidiaries, taken as a whole, have been adequately described in the Registration Statement and the Prospectus in all material respects. The preclinical studies and clinical trials conducted by or on behalf
        of the Company were and, if still ongoing, are being conducted in material compliance with all laws and regulations applicable thereto in the jurisdictions in which they are being conducted and with all laws and regulations applicable to
        preclinical studies and clinical trials from which data will be submitted to support marketing approval, except where the failure to be in compliance would not, individually or in the aggregate, reasonably be expected to have a Material Adverse
        Change. The descriptions in the Registration Statement and the Prospectus of the results of such studies and trials are accurate and complete in all material respects and fairly present the data derived from such studies. The Company has no
        knowledge of any well-controlled Phase 2 or Phase 3 clinical trial the aggregate results of which call into question in any material respect the results of any clinical trial conducted by or on behalf of the Company that are described or referred
        to in the Registration Statement and the Prospectus. Except as disclosed in the Registration Statement and the Prospectus, the Company has not received any written notices or statements from the FDA, the NMPA or any comparable drug regulatory
        agency (each, a &#8220;<font style="font-weight: bold;">Regulatory Authority</font>&#8221;) imposing, requiring, requesting or suggesting a clinical hold, termination, suspension or material modification for or of any preclinical studies or clinical trials
        that are described or the results of which are referred to in the Registration Statement, the Prospectus. Except as disclosed in the Registration Statement and the Prospectus, the Company has not received any notices or statements from any
        Regulatory Authority, and otherwise has no knowledge that (i) any investigational new drug application for any potential product of the Company has been rejected or determined to be non-approvable or conditionally approvable; or (ii) any license,
        approval, permit or authorization to conduct any clinical trial of any potential product of the Company has been, will be or is reasonably likely to be suspended, revoked, materially modified or limited.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(nn)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">OFAC.</font><font style="font-weight: bold;">&#160; </font>Neither the Company nor any of its subsidiaries nor, to
        the knowledge of the Company, any director, officer, agent, employee or affiliate of the Company or any of its subsidiaries (i) is, or is controlled or 50% or more owned in the aggregate by or is acting on behalf of, one or more individuals or
        entities that are currently the subject of any sanctions administered or enforced by the United States (including any administered or enforced by the Office of Foreign Assets Control of the U.S. Department of the Treasury, the U.S. Department of
        State or the Bureau of Industry and Security of the U.S. Department of Commerce), the United Nations Security Council, the European Union, a member state of the European Union (including sanctions administered or enforced by Her Majesty&#8217;s Treasury
        of the United Kingdom) or other relevant sanctions authority (collectively, &#8220;<font style="font-weight: bold;">Sanctions</font>&#8221; and such persons, &#8220;<font style="font-weight: bold;">Sanctioned Persons</font>&#8221; and each such person, a &#8220;<font style="font-weight: bold;">Sanctioned Person</font>&#8221;), (ii) is located, organized or resident in a country or territory that is, or whose government is, the subject of Sanctions that broadly prohibit dealings with that country or territory
        (collectively, &#8220;<font style="font-weight: bold;">Sanctioned Countries</font>&#8221; and each, a &#8220;<font style="font-weight: bold;">Sanctioned Country</font>&#8221;) or (iii) will, directly or indirectly, use the proceeds of this offering, or lend, contribute or
        otherwise make available such proceeds to any subsidiary, joint venture partner or other individual or entity in any manner that would result in a violation of any Sanctions by, or could reasonably be expected to result in the imposition of
        Sanctions against, any individual or entity (including any individual or entity participating in the offering, whether as underwriter, advisor, investor or otherwise).</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">13</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(oo)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Dealings with Sanctioned Persons or Sanctioned Countries.</font><font style="font-weight: bold;">&#160;</font>Neither
        the Company nor any of its subsidiaries has engaged in any dealings or transactions with or for the benefit of a Sanctioned Person, or with or in a Sanctioned Country, in the preceding three years, nor does the Company or any of its subsidiaries
        have any plans to engage in dealings or transactions with or for the benefit of a Sanctioned Person, or with or in a Sanctioned Country.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(pp)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Cybersecurity; Data Protection.</font><font style="font-weight: bold;">&#160;</font>Except as disclosed in the
        Prospectus, (A)(i) the Company has not been notified of, and has not suffered, any security breach or other compromise of or relating to any of the Company&#8217;s information technology and computer systems, networks, hardware, software, data
        (including, to the knowledge of the Company, the data of its customers, employees, suppliers, vendors and any third party data maintained by or on behalf of it), equipment or technology (collectively, &#8220;IT Systems and Data&#8221;) and (ii) the Company has
        not been notified of, and has no knowledge of, any event or condition that would reasonably be expected to result in any security breach or other compromise to its IT Systems and Data, except in the case of this clause (i) and (ii) as would not,
        individually or in the aggregate, have a Material Adverse Change; (B) the Company is presently in compliance in all material respects with applicable laws or statutes and all judgments, orders, rules and regulations of any court or arbitrator or
        governmental or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems and Data and to the protection of such IT Systems and Data from unauthorized use, access, misappropriation or
        modification, except as would not, individually or in the aggregate, have a Material Adverse Change; and (C) the Company has implemented security, backup and disaster recovery technology consistent with industry standards and practices.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(qq)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">CSRC. </font>Each of the Company and each of the Company&#8217;s directors that signed the Registration Statement is
        aware of and has been advised as to, the content of the Rules on Mergers and Acquisitions of Domestic Enterprises by Foreign Investors jointly promulgated by the Ministry of Commerce, the State Assets Supervision and Administration Commission, the
        State Tax Administration, the State Administration of Industry and Commerce, the China Securities Regulatory Commission (the &#8220;<font style="font-weight: bold;">CSRC</font>&#8221;) and the State Administration of Foreign Exchange of the People&#8217;s Republic
        of China (the &#8220;<font style="font-weight: bold;">PRC</font>&#8221;) on August 8, 2006 and as amended on June 22, 2009 (the &#8220;<font style="font-weight: bold;">M&amp;A Rules</font>&#8221;), in particular the relevant provisions thereof which purport to require
        offshore special purpose vehicles, formed for listing purposes and controlled directly or indirectly by PRC companies or individuals, to obtain approval of the CSRC prior to the listing and trading of their securities on an overseas stock exchange;
        the Company has received legal advice specifically with respect to the M&amp;A Rules from its Chinese counsel and the Company understands such legal advice; and the Company has fully communicated such legal advice from its Chinese counsel to each
        of its directors that signed the Registration Statement and each director has confirmed that he or she understands such legal advice. The issuance and sale of the Offered Shares, the listing and trading of the Offered Shares on the Nasdaq or the
        consummation of the transactions contemplated by this Agreement is not, as of the date hereof, and will not be, on the Closing Date and on any settlement date, adversely affected by the M&amp;A Rules or any official clarifications, guidance,
        interpretations or implementation rules in connection with or related to the M&amp;A Rules (collectively, the &#8220;M&amp;A Rules and Related Clarifications&#8221;).</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(rr)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">PRC Overseas Investment and Foreign Exchange.</font> Each of the Company and its subsidiaries that were
        incorporated outside of the PRC has taken, or is in the process of taking, if applicable, reasonable steps to comply with, and to ensure compliance by each of its shareholders and option holders that is, or is directly or indirectly owned or
        controlled by, a PRC resident or citizen with any applicable rules and regulations of the relevant PRC government agencies (including but not limited to the Ministry of Commerce, the National Development and Reform Commission and the State
        Administration of Foreign Exchange) relating to overseas investment by PRC residents and citizens or the repatriation of the profits or investment gains realized by such PRC residents and citizens, or the repatriation of the proceeds from overseas
        offering and listing by the Company to the PRC (the &#8220;<font style="font-weight: bold;">PRC Overseas Investment and Listing Regulations and Foreign Exchange Regulations</font>&#8221;), including without limitation, requesting each shareholder and option
        holder that is, or is directly or indirectly owned or controlled by, a PRC resident or citizen to complete any registration and other procedures required under applicable PRC Overseas Investment and Listing Regulations and Foreign Exchange
        Regulations.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">14</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ss)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Brokers</font><font style="font-weight: bold;">.&#160; </font>Except as otherwise disclosed in the Prospectus,
        there is no broker, finder or other party that is entitled to receive from the Company any brokerage or finder&#8217;s fee or other fee or commission as a result of any transactions contemplated by this Agreement.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(tt)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Outstanding Loans or Other Extensions of Credit</font>. Except as otherwise disclosed in the Prospectus,
        since the adoption of Section 13(k) of the Exchange Act, neither the Company nor any of its subsidiaries has extended or maintained credit, arranged for the extension of credit, or renewed any extension of credit, in the form of a personal loan, to
        or for any director or executive officer (or equivalent thereof) of the Company and/or such subsidiary except for such extensions of credit as are expressly permitted by Section 13(k) of the Exchange Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(uu)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Sarbanes-Oxley Act.</font> The Company is in compliance, in all material respects, with all applicable
        provisions of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated thereunder.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(vv)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Foreign Private Issuer.</font> The Company is a &#8220;foreign private issuer&#8221; within the meaning of Rule 405 under
        the Securities Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(ww)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Submission to Jurisdiction</font>.&#160; The Company has the power to submit, and pursuant to Section 19 of this
        Agreement, has legally, validly, effectively and irrevocably submitted, to the personal jurisdiction of each United States federal court and New York state court located in the Borough of Manhattan, in the City of New York, New York, U.S.A. (each,
        a &#8220;<font style="font-weight: bold;">New York Court</font>&#8221;), and the Company has the power to designate, appoint and authorize, and pursuant to Section 19 of this Agreement, has legally, validly, effectively and irrevocably designated, appointed
        and authorized an agent for service of process in any action arising out of or relating to this Agreement or the Offered Shares in any New York Court, and service of process effected on such authorized agent will be effective to confer valid
        personal jurisdiction over the Company as provided in Section 19 hereof.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(xx)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Rights of Immunity</font>.&#160; Except as provided by laws or statutes generally applicable to transactions of
        the type described in this Agreement, neither the Company nor any of its respective properties, assets or revenues has any right of immunity under the laws of the Cayman Islands, New York or United States law, from any legal action, suit or
        proceeding, from the giving of any relief in any such legal action, suit or proceeding, from set-off or counterclaim, from the jurisdiction of any law of the Cayman Islands, New York or United States federal court, from service of process,
        attachment upon or prior judgment, or attachment in aid of execution of judgment, or from execution of a judgment, or other legal process or proceeding for the giving of any relief or for the enforcement of a judgment, in any such court, with
        respect to its obligations, liabilities or any other matter under or arising out of or in connection with this Agreement.&#160; To the extent that the Company or any of its respective properties, assets or revenues may have or may hereafter become
        entitled to any such right of immunity in any such court in which proceedings may at any time be commenced, the Company waives or will waive such right to the extent permitted by law and has consented to such relief and enforcement as provided in
        Section 19 of this Agreement.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">15</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(yy)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Enforceability of Judgments</font>. Under the laws of the Cayman Islands and as described in the Prospectus,
        the courts of the Cayman Islands will recognize and give effect to the choice of law provisions set forth in Section 16 hereof and enforce judgments of U.S. courts obtained against the Company to enforce this Agreement, without re-examination or
        review of the merits of the cause of action in respect of which the original judgment was given or re-litigation of the matters adjudicated upon, by an action commenced on the foreign judgment debt in the Grand Court of the Cayman Islands, provided
        such judgment (i) is given by a court of competent jurisdiction, (ii) imposes on the judgment debtor a liability to pay a liquidated sum for which the judgment has been given, (iii) is final and conclusive, (iv) is not in respect of taxes, a fine
        or a penalty, and (v) was not obtained in a manner and is not of a kind the enforcement of which is contrary to natural justice or the public policy of the Cayman Islands. Under the laws of the PRC, the choice of law provisions set forth in Section
        16 hereof will be recognized by the courts of the PRC and any judgment obtained in any state or federal court located in the Borough of Manhattan, The City of New York, New York (each, a &#8220;<font style="font-weight: bold;">New York Court</font>&#8221;)
        arising out of or in relation to the obligations of the Company under this Agreement will be recognized in PRC courts subject to the applicable provisions of the Civil Procedure Law of the PRC and the PRC General Principles of Civil Law relating to
        the enforceability of foreign judgments and the statements set forth in the Prospectus under the caption &#8220;Enforcement of Civil Liabilities&#8221;.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(zz)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Forward-Looking Statements.</font>&#160; Each financial or operational projection or other &#8220;forward-looking
        statement&#8221; (as defined by Section 27A of the Securities Act or Section 21E of the Exchange Act) contained in the Registration Statement, the Time of Sale Prospectus or the Prospectus (i) was so included by the Company in good faith and with
        reasonable basis after due consideration by the Company of the underlying assumptions, estimates and other applicable facts and circumstances and (ii) is accompanied by meaningful cautionary statements identifying those factors that could cause
        actual results to differ materially from those in such forward&#8209;looking statement.&#160; No such statement was made with the knowledge of an executive officer or director of the Company that it was false or misleading.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">Any certificate signed by any officer of the Company or any of its subsidiaries and delivered to any Underwriter or to counsel for the Underwriters in connection with the offering, or the purchase and sale, of the
        Offered Shares shall be deemed a representation and warranty by the Company to each Underwriter as to the matters covered thereby on the date of such certificate.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The Company acknowledges that the Underwriters and, for purposes of the opinions to be delivered pursuant to Section 6 hereof, counsel to the Company and counsel to the Underwriters, will rely upon the accuracy and
        truthfulness of the foregoing representations and hereby consents to such reliance.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 2.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Purchase, Sale and Delivery of the Offered Shares.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">The Firm Shares</font><font style="font-weight: bold;">.</font>&#160; Upon the terms herein set forth, the Company
        agrees to issue and sell to the several Underwriters an aggregate of 7,500,000 Firm Shares.&#160; On the basis of the representations, warranties and agreements herein contained, and upon the terms but subject to the conditions herein set forth, the
        Underwriters agree, severally and not jointly, to purchase from the Company the respective number of Firm Shares set forth opposite their names on <u>Schedule A</u>.&#160; The purchase price per Offered Share to be paid by the several Underwriters to
        the Company shall be $9.35 per share.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">The First Closing Date</font><font style="font-weight: bold;">.</font>&#160; Delivery of the Firm Shares to be
        purchased by the Underwriters and payment therefor shall be made at the offices of Goodwin Procter LLP (or such other place as may be agreed to by the Company and the Representatives) at 9:00 a.m. New York City time, on November 23, 2020<font style="font-weight: bold;">,</font> or such other time and date not later than 1:30 p.m. New York City time, on November 23, 2020 as the Representatives shall designate by notice to the Company (the time and date of such closing are called the &#8220;<font style="font-weight: bold;">First Closing Date</font>&#8221;).&#160; The Company hereby acknowledges that circumstances under which the Representatives may provide notice to postpone the First Closing Date as originally scheduled include, but are not limited
        to, any determination by the Company or the Representatives to recirculate to the public copies of an amended or supplemented Prospectus or a delay as contemplated by the provisions of Section 11.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">16</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">The Optional Shares; Option Closing Date</font><font style="font-weight: bold;">.</font>&#160; In addition, on the
        basis of the representations, warranties and agreements herein contained, and upon the terms but subject to the conditions herein set forth, the Company hereby grants an option to the several Underwriters to purchase, severally and not jointly, up
        to an aggregate of 1,125,000 Optional Shares from the Company at the purchase price per share to be paid by the Underwriters for the Firm Shares, less an amount per share equal to any dividend or distribution declared by the Company and payable on
        the Firm Shares, but not payable on Optional Shares.&#160; The option granted hereunder may be exercised at any time and from time to time in whole or in part upon notice by the Representatives to the Company (with a copy to the Company), which notice
        may be given at any time within 30 days from the date of this Agreement.&#160; Such notice shall set forth (i) the aggregate number of Optional Shares as to which the Underwriters are exercising the option and (ii) the time, date and place at which
        certificates for the Optional Shares will be delivered (which time and date may be simultaneous with, but not earlier than, the First Closing Date; and in the event that such time and date are simultaneous with the First Closing Date, the term &#8220;<font style="font-weight: bold;">First Closing Date</font>&#8221; shall refer to the time and date of delivery of the Firm Shares and such Optional Shares).&#160; Any such time and date of delivery, if subsequent to the First Closing Date, is called an &#8220;<font style="font-weight: bold;">Option Closing Date</font>,&#8221; and shall be determined by the Representatives and shall not be earlier than two or later than five full business days after delivery of such notice of exercise.&#160; If any Optional Shares are
        to be purchased, each Underwriter agrees, severally and not jointly, to purchase the number of Optional Shares (subject to such adjustments to eliminate fractional shares as the Representatives may determine) that bears the same proportion to the
        total number of Optional Shares to be purchased as the number of Firm Shares set forth on <u>Schedule A</u> opposite the name of such Underwriter bears to the total number of Firm Shares and the Representatives may cancel the option at any time
        prior to its expiration by giving written notice of such cancellation to the Company.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Public Offering of the Offered Shares</font><font style="font-weight: bold;">.</font>&#160; The Representatives
        hereby advise the Company&#160; that the Underwriters intend to offer for sale to the public, initially on the terms set forth in the Registration Statement, the Time of Sale Prospectus and the Prospectus, their respective portions of the Offered Shares
        as soon after this Agreement has been executed as the Representatives, in their sole judgment, have determined is advisable and practicable.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Payment for the Offered Shares</font><font style="font-weight: bold;">.&#160; </font>(1)<font style="font-weight: bold;">&#160;</font>Payment for the Offered Shares to be sold by the Company shall be made at the First Closing Date (and, if applicable, at each Option Closing Date) by wire transfer of immediately available funds to the order of the Company.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;It is understood that the Representatives have been authorized, for their own account and the accounts of the several Underwriters, to accept delivery of and receipt for, and make payment of the purchase
        price for, the Firm Shares and any Optional Shares the Underwriters have agreed to purchase.&#160; Each of BofA, Jefferies and Evercore, individually and not as the Representatives of the Underwriters, may (but shall not be obligated to) make payment
        for any Offered Shares to be purchased by any Underwriter whose funds shall not have been received by the Representatives by the First Closing Date or the applicable Option Closing Date, as the case may be, for the account of such Underwriter, but
        any such payment shall not relieve such Underwriter from any of its obligations under this Agreement.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Delivery of the Offered Shares</font><font style="font-weight: bold;">.</font>&#160; The Company shall deliver, or
        cause to be delivered to the Representatives for the accounts of the several Underwriters, the Firm Shares at the First Closing Date, against release of a wire transfer of immediately available funds for the amount of the purchase price therefor.&#160;
        The Company shall also deliver, or cause to be delivered to the Representatives for the accounts of the several Underwriters, the Optional Shares the Underwriters have agreed to purchase at the First Closing Date or the applicable Option Closing
        Date, as the case may be, against the release of a wire transfer of immediately available funds for the amount of the purchase price therefor.&#160; If BofA so elects, delivery of the Offered Shares may be made by credit to the accounts designated by
        BofA through The Depository Trust Company&#8217;s full fast transfer or DWAC programs. Time shall be of the essence, and delivery at the time and place specified in this Agreement is a further condition to the obligations of the Underwriters.</div>
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      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 3.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Additional Covenants of the Company.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The Company further covenants and agrees with each Underwriter as follows:</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Delivery of Registration Statement, Time of Sale Prospectus and Prospectus.</font><font style="font-style: italic;">&#160;</font> The Company shall furnish to you in New York City, without charge, prior to 10:00 a.m. New York City time on the business day next succeeding the date of this Agreement and during the period when a prospectus relating to the
        Offered Shares is required by the Securities Act to be delivered (whether physically or through compliance with Rule 172 under the Securities Act or any similar rule) in connection with sales of the Offered Shares, as many copies of the Time of
        Sale Prospectus, the Prospectus and any supplements and amendments thereto or to the Registration Statement as you may reasonably request.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Representatives&#8217; Review of Proposed Amendments and Supplements.</font><font style="font-style: italic;">&#160;</font>
        During the period when a prospectus relating to the Offered Shares is required by the Securities Act to be delivered (whether physically or through compliance with Rule 172 under the Securities Act or any similar rule), the Company (i) will furnish
        to the Representatives for review, a reasonable period of time prior to the proposed time of filing of any proposed amendment or supplement to the Registration Statement, a copy of each such amendment or supplement and (ii) will not amend or
        supplement the Registration Statement (including, in each case, any amendment or supplement through incorporation of any report filed under the Exchange Act), without the Representatives&#8217; prior written consent.&#160; Prior to amending or supplementing
        any preliminary prospectus, the Time of Sale Prospectus or the Prospectus (including any amendment or supplement through incorporation of any report filed under the Exchange Act), the Company shall furnish to the Representatives for review, a
        reasonable amount of time prior to the time of filing or use of the proposed amendment or supplement, a copy of each such proposed amendment or supplement.&#160; The Company shall not file or use any such proposed amendment or supplement without the
        Representatives&#8217; prior written consent.&#160; The Company shall file with the Commission within the applicable period specified in Rule 424(b) under the Securities Act any prospectus required to be filed pursuant to such Rule.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Free Writing Prospectuses.</font><font style="font-style: italic;">&#160;</font> The Company shall furnish to the
        Representatives for review, a reasonable amount of time prior to the proposed time of filing or use thereof, a copy of each proposed free writing prospectus or any amendment or supplement thereto prepared by or on behalf of, used by, or referred to
        by the Company, and the Company shall not file, use or refer to any proposed free writing prospectus or any amendment or supplement thereto without the Representatives&#8217; prior written consent.&#160; The Company shall furnish to each Underwriter, without
        charge, as many copies of any free writing prospectus prepared by or on behalf of, used by or referred to by the Company as such Underwriter may reasonably request.&#160; If at any time when a prospectus is required by the Securities Act to be delivered
        (whether physically or through compliance with Rule 172 under the Securities Act or any similar rule) in connection with sales of the Offered Shares (but in any event if at any time through and including the First Closing Date) there occurred or
        occurs an event or development as a result of which any free writing prospectus prepared by or on behalf of, used by, or referred to by the Company conflicted or would conflict with the information contained in the Registration Statement or
        included or would include an untrue statement of a material fact or omitted or would omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances prevailing at such time, not misleading, the
        Company shall promptly amend or supplement such free writing prospectus to eliminate or correct such conflict or so that the statements in such free writing prospectus as so amended or supplemented will not include an untrue statement of a material
        fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances prevailing at such time, not misleading, as the case may be; <font style="font-style: italic;">provided, however</font>,
        that prior to amending or supplementing any such free writing prospectus, the Company shall furnish to the Representatives for review, a reasonable amount of time prior to the proposed time of filing or use thereof, a copy of such proposed amended
        or supplemented free writing prospectus, and the Company shall not file, use or refer to any such amended or supplemented free writing prospectus without the Representatives&#8217; prior written consent.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">18</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Filing of Underwriter Free Writing Prospectuses.</font><font style="font-style: italic;">&#160;</font> The Company
        shall not take any action that would result in an Underwriter or the Company being required to file with the Commission pursuant to Rule 433(d) under the Securities Act a free writing prospectus prepared by or on behalf of such Underwriter that
        such Underwriter otherwise would not have been required to file thereunder.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Amendments and Supplements to Time of Sale Prospectus.</font><font style="font-style: italic;">&#160;</font> If the
        Time of Sale Prospectus is being used to solicit offers to buy the Offered Shares at a time when the Prospectus is not yet available to prospective purchasers, and any event shall occur or condition exist as a result of which it is necessary to
        amend or supplement the Time of Sale Prospectus so that the Time of Sale Prospectus does not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the
        circumstances when delivered to a prospective purchaser, not misleading, or if any event shall occur or condition exist as a result of which the Time of Sale Prospectus conflicts with the information contained in the Registration Statement, or if,
        in the opinion of counsel for the Underwriters, it is necessary to amend or supplement the Time of Sale Prospectus to comply with applicable law, the Company shall (subject to Section 3(b) and Section 3(c) hereof) promptly prepare, file with the
        Commission and furnish, at its own expense, to the Underwriters and to any dealer upon request, either amendments or supplements to the Time of Sale Prospectus so that the statements in the Time of Sale Prospectus as so amended or supplemented will
        not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances when delivered to a prospective purchaser, not misleading or so that the Time
        of Sale Prospectus, as amended or supplemented, will no longer conflict with the information contained in the Registration Statement, or so that the Time of Sale Prospectus, as amended or supplemented, will comply with applicable law.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Certain Notifications and Required Actions</font><font style="font-weight: bold;">.</font>&#160; After the date of
        this Agreement, the Company shall promptly advise the Representatives in writing of: (i) the receipt of any comments of, or requests for additional or supplemental information from, the Commission; (ii) the time and date of any filing of any
        post-effective amendment to the Registration Statement or any amendment or supplement to any preliminary prospectus, the Time of Sale Prospectus, any free writing prospectus or the Prospectus; (iii) the time and date that any post-effective
        amendment to the Registration Statement becomes effective; and (iv) the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement or any post-effective amendment thereto or any amendment or supplement
        to any preliminary prospectus, the Time of Sale Prospectus or the Prospectus or of any order preventing or suspending the use of any preliminary prospectus, the Time of Sale Prospectus, any free writing prospectus or the Prospectus, or of any
        proceedings to remove, suspend or terminate from listing or quotation the Offered Shares from any securities exchange upon which they are listed for trading or included or designated for quotation, or of the threatening or initiation of any
        proceedings for any of such purposes.&#160; If the Commission shall enter any such stop order at any time, the Company will use its reasonable best efforts to obtain the lifting of such order at the earliest possible moment.&#160; Additionally, the Company
        agrees that it shall comply with all applicable provisions of Rule 424(b), Rule 433 and Rule 430B under the Securities Act and will use its reasonable efforts to confirm that any filings made by the Company under Rule 424(b) or Rule 433 were
        received in a timely manner by the Commission.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">19</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Amendments and Supplements to the Prospectus and Other Securities Act Matters.</font>&#160; If any event shall occur
        or condition exist as a result of which it is necessary to amend or supplement the Prospectus so that the Prospectus does not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements
        therein, in the light of the circumstances when the Prospectus is delivered (whether physically or through compliance with Rule 172 under the Securities Act or any similar rule) to a purchaser, not misleading, or if in the opinion of the
        Representatives or counsel for the Underwriters it is otherwise necessary to amend or supplement the Prospectus to comply with applicable law, the Company agrees (subject to Section 3 (b) and Section 3 (c)) hereof to promptly prepare, file with the
        Commission and furnish, at its own expense, to the Underwriters and to any dealer upon request, amendments or supplements to the Prospectus so that the statements in the Prospectus as so amended or supplemented will not include an untrue statement
        of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances when the Prospectus is delivered (whether physically or through compliance with Rule 172 under the Securities
        Act or any similar rule) to a purchaser, not misleading or so that the Prospectus, as amended or supplemented, will comply with applicable law.&#160; Neither the Representatives&#8217; consent to, nor delivery of, any such amendment or supplement shall
        constitute a waiver of any of the Company&#8217;s obligations under Section 3(b) or Section 3(c).</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Blue Sky Compliance</font><font style="font-weight: bold;">.</font>&#160; The Company shall cooperate with the
        Representatives and counsel for the Underwriters to qualify or register the Offered Shares for sale under (or obtain exemptions from the application of) the state securities or blue sky laws or Canadian provincial securities law or other foreign
        laws of those jurisdictions designated by the Representatives, shall comply with such laws and shall continue such qualifications, registrations and exemptions in effect so long as required for the distribution of the Offered Shares.&#160; The Company
        shall not be required to qualify as a foreign corporation or to take any action that would subject it to general service of process in any such jurisdiction where it is not presently qualified.&#160; The Company will advise the Representatives promptly
        of the suspension of the qualification or registration of (or any such exemption relating to) the Offered Shares for offering, sale or trading in any jurisdiction or any initiation or threat of any proceeding for any such purpose, and in the event
        of the issuance of any order suspending such qualification, registration or exemption, the Company shall use its best efforts to obtain the withdrawal thereof at the earliest possible moment.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Use of Proceeds</font><font style="font-weight: bold;">.</font>&#160; The Company shall apply the net proceeds from
        the sale of the Offered Shares sold by it in the manner described under the caption &#8220;Use of Proceeds&#8221; in the Registration Statement, the Time of Sale Prospectus and the Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(j)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Earnings Statement</font><font style="font-weight: bold;">.</font>&#160; The Company will make generally available to
        its security holders and to the Representatives as soon as practicable an earnings statement (which need not be audited) covering a period of at least twelve months beginning with the first fiscal quarter of the Company commencing after the date of
        this Agreement that will satisfy the provisions of Section 11(a) of the Securities Act and the rules and regulations of the Commission thereunder.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(k)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Continued Compliance with Securities Laws</font><font style="font-weight: bold;">.</font>&#160; The Company will
        comply with the Securities Act and the Exchange Act so as to permit the completion of the distribution of the Offered Shares as contemplated by this Agreement,<font style="font-weight: bold;">&#160;</font>the Registration Statement, the Time of Sale
        Prospectus and the Prospectus.&#160; Without limiting the generality of the foregoing, the Company will, during the period when a prospectus relating to the Offered Shares is required by the Securities Act to be delivered (whether physically or through
        compliance with Rule 172 under the Securities Act or any similar rule), file on a timely basis with the Commission and the Nasdaq all reports and documents required to be filed under the Exchange Act.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">20</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(l)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;"><font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Listing</font><font style="font-weight: bold;">.</font>&#160; The Company will use its best efforts to list, subject to notice of issuance, the Offered Shares on the Nasdaq.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(m)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Company to Provide Copy of the Prospectus in Form That May be Downloaded from the Internet</font><font style="font-weight: bold;">.</font>&#160; If requested by the Representatives, the Company shall cause to be prepared and delivered, at its expense, within one business day from the effective date of this Agreement, to the Representatives an &#8220;<font style="font-weight: bold;">electronic Prospectus</font>&#8221; to be used by the Underwriters in connection with the offering and sale of the Offered Shares.&#160; As used herein, the term &#8220;<font style="font-weight: bold;">electronic Prospectus</font>&#8221;
        means a form of Prospectus, and any amendment or supplement thereto, that meets each of the following conditions: (i) it shall be encoded in an electronic format, satisfactory to the Representatives, that may be transmitted electronically by the
        Representatives and the other Underwriters to offerees and purchasers of the Offered Shares; (ii) it shall disclose the same information as the paper Prospectus, except to the extent that graphic and image material cannot be disseminated
        electronically, in which case such graphic and image material shall be replaced in the electronic Prospectus with a fair and accurate narrative description or tabular representation of such material, as appropriate; and (iii) it shall be in or
        convertible into a paper format or an electronic format, satisfactory to the Representatives, that will allow investors to store and have continuously ready access to the Prospectus at any future time, without charge to investors (other than any
        fee charged for subscription to the Internet as a whole and for on-line time).&#160; The Company hereby confirms that it has included or will include in the Prospectus filed pursuant to EDGAR or otherwise with the Commission and in the Registration
        Statement at the time it was declared effective an undertaking that, upon receipt of a request by an investor or his or her representative, the Company shall transmit or cause to be transmitted promptly, without charge, a paper copy of the
        Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(n)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Agreement Not to Offer or Sell Additional Shares</font><font style="font-weight: bold;">.&#160; </font>During the
        period commencing on and including the date hereof and continuing through and including the 90th day following the date of the Prospectus (such period being referred to herein as the &#8220;<font style="font-weight: bold;">Lock-up Period</font>&#8221;), the
        Company will not, without the prior written consent of BofA, Jefferies and Evercore (which consent may be withheld in their sole discretion), directly or indirectly:(i) sell, offer to sell, contract to sell or lend any Ordinary Shares or Related
        Securities (as defined below); (ii) effect any short sale, or establish or increase any &#8220;put equivalent position&#8221; (as defined in Rule 16a-1(h) under the Exchange Act) or liquidate or decrease any &#8220;call equivalent position&#8221; (as defined in Rule
        16a&#8209;1(b) under the Exchange Act) of any Ordinary Shares or Related Securities; (iii) pledge, hypothecate or grant any security interest in any Ordinary Shares or Related Securities; (iv) in any other way transfer or dispose of any Ordinary Shares
        or Related Securities; (v) enter into any swap, hedge or similar arrangement or agreement that transfers, in whole or in part, the economic risk of ownership of any Ordinary Shares or Related Securities, regardless of whether any such transaction
        is to be settled in securities, in cash or otherwise; (vi) announce the offering of any Ordinary Shares or Related Securities; (vii) submit or file any registration statement under the Securities Act in respect of any Ordinary Shares or Related
        Securities (other than as contemplated by this Agreement with respect to the Offered Shares); (viii) effect a reverse stock split, recapitalization, share consolidation, reclassification or similar transaction affecting the outstanding Ordinary
        Shares; (ix) publicly announce the intention to do any of the foregoing; or (x) the Ordinary Shares to be sold pursuant to the related private placement as described in the Registration Statement, the Time of Sale Prospectus and Prospectus; <font style="font-style: italic;">provided, </font>that the Company may (A) effect the transactions contemplated hereby; (B) issue Ordinary Shares, grant options to purchase Ordinary Shares, restricted stock or restricted stock units or other equity
        awards, pursuant to any share option, share bonus or other share plan or arrangement described in the Registration Statement, the Time of Sale Prospectus and the Prospectus, but only if the holders of such Ordinary Shares or options agree in
        writing with the Underwriters not to sell, offer, dispose of or otherwise transfer any such Ordinary Shares or options during such Lock-up Period without the prior written consent of BofA, Jefferies and Evercore (which consent may be withheld in
        their sole discretion); (C) grant options, restricted shares or other awards to the Company&#8217;s directors, employees and consultants under the 2017 Omnibus Incentive Plan as described in the Prospectus, (D) issue Ordinary Shares pursuant to the
        conversion or exchange of convertible or exchangeable securities or the exercise of options described in the Registration Statement, the Disclosure Package and the Prospectus, (E) file a registration statement on Form S-8 to register Ordinary
        Shares issuable pursuant to the terms of a share option, share bonus or other share plan or arrangement (including any amendment thereto) described in the Registration Statement, the Time of Sale Prospectus and the Prospectus, (F) acknowledge or
        agree to a trading plan to be established pursuant to Rule 10b5-1 under the Exchange Act for the transfer of Ordinary Shares by certain officers or directors of the Company, provided that (i) such plan does not provide for the transfer of Ordinary
        Shares during the Lock-up Period and (ii) to the extent a public announcement or filing under the Exchange Act, if any, is</div>
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      <div>required of or voluntarily made by or on behalf of the Company regarding the establishment of the plan, such announcement or filing shall include a statement to the effect that no transfer of Ordinary Shares may be made under such plan during
        the Lock-up Period, and (G) issue Ordinary Shares in connection with any joint venture, commercial or collaborative relationship or the acquisition or license by the Company of the securities, businesses, property or other assets of another person
        or entity or pursuant to any employee benefit plan as assumed by the Company in connection with any such acquisition; <font style="font-style: italic;">provided, however</font> that in the case of clause (G), (i) such Ordinary Shares shall not in
        the aggregate exceed 5.0% of the Company&#8217;s outstanding Ordinary Shares immediately following the consummation of the offering of the Offered Shares contemplated by this Agreement and (ii) the recipient thereof provide to the Representatives a
        signed letter substantially in the form of <u>Exhibit F</u> hereto. For purposes of the foregoing, &#8220;<font style="font-weight: bold;">Related Securities</font>&#8221; shall mean any options or warrants or other rights to acquire Ordinary Shares or any
        securities exchangeable or exercisable for or convertible into Ordinary Shares, or to acquire other securities or rights ultimately exchangeable or exercisable for, or convertible into, or Ordinary Shares.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(o)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Future Reports to the Representatives.&#160; </font>During the period of five years hereafter, the Company will
        furnish to the Representatives, BofA Securities, Inc., at One Bryant Park, New York, NY 10036, Attention: Syndicate Department, with a copy to Attention: ECM Legal, c/o Jefferies, at 520 Madison Avenue, New York, New York 10022, Attention: Global
        Head of Syndicate and c/o Evercore Group L.L.C., 55 East 52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street, New York, New York 10055, Attention: Kenneth A. Masotti, Esq.: (i) as soon as practicable after
        the end of each fiscal year, copies of the Annual Report of the Company containing the balance sheet of the Company as of the close of such fiscal year and statements of income, stockholders&#8217;<font style="font-style: italic;">&#160;</font>equity and cash
        flows for the year then ended and the opinion thereon of the Company&#8217;s independent public or certified public accountants; (ii) as soon as practicable after the filing thereof, copies of each Annual Report on Form 20-F, Report on Form 6-K or other
        report filed by the Company with the Commission, FINRA or any securities exchange; and (iii) as soon as available, copies of any report or communication of the Company furnished or made available generally to holders of its share capital; <font style="font-style: italic;">provided, however,</font> that the requirements of this Section 3(p) shall be satisfied to the extent that such reports, statement, communications, financial statements or other documents are available on EDGAR.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(p)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Investment Limitation</font><font style="font-weight: bold;">.</font>&#160; The Company shall not invest or otherwise
        use the proceeds received by the Company from its sale of the Offered Shares in such a manner as would require the Company or any of its subsidiaries to register as an investment company under the Investment Company Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(q)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Stabilization or Manipulation; Compliance with Regulation M</font><font style="font-weight: bold;">. </font>The
        Company will not take, and will ensure that no affiliate of the Company will take, directly or indirectly, any action designed to or that might cause or result in stabilization or manipulation of the price of the Offered Shares or any reference
        security with respect to the Offered Shares, whether to facilitate the sale or resale of the Offered Shares or otherwise, and the Company will, and shall cause each of its affiliates to, comply with all applicable provisions of Regulation M.</div>
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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">22</font></div>
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      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(r)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Company to Provide Interim Financial Statements</font><font style="font-weight: bold;">.</font>&#160; Prior to the
        First Closing Date and each applicable Option Closing Date, the Company will furnish the Underwriters, as soon as they have been prepared by or are available to the Company, a copy of any unaudited interim financial statements of the Company for
        any period subsequent to the period covered by the most recent financial statements appearing in the Registration Statement and the Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(s)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Transfer Agent</font>.&#160; The Company agrees to maintain a transfer agent and, if necessary, under the
        jurisdiction of the Cayman Islands of the Company, a registrar for the Shares.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(t)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Amendments and Supplements to Permitted Section 5(d) Communications. </font><font style="font-style: italic;">&#160;</font>If
        at any time following the distribution of any Permitted Section 5(d) Communication, there occurred or occurs an event or development as a result of which such Permitted Section 5(d) Communication included or would include an untrue statement of a
        material fact or omitted or would omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances existing at that subsequent time, not misleading, the Company will promptly notify the
        Representatives and will promptly amend or supplement, at its own expense, such Permitted Section 5(d) Communication to eliminate or correct such&#160; untrue statement or omission.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(u)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Emerging Growth Company Status.</font>&#160; The Company will promptly notify the Representatives if the Company
        ceases to be an Emerging Growth Company at any time prior to the later of (i) the time when a prospectus relating to the Offered Shares is not required by the Securities Act to be delivered (whether physically or through compliance with Rule 172
        under the Securities Act or any similar rule) and (ii) the expiration of the Lock-Up Period (as defined herein).</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(v)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Sales Taxes.</font>&#160; If the performance by the Underwriters of any of their obligations under this Agreement
        shall represent for VAT purposes under any applicable law the making by the Underwriters of any supply of goods or services to the Company (to the extent applicable), the Company shall pay to the Underwriters, in addition to the amounts otherwise
        payable by the Company pursuant to this Agreement, an amount equal to the VAT chargeable on any such supply of goods and services provided that the Underwriters have issued the Company with an appropriate VAT invoice in respect of the supply to
        which the payment relates. For the purposes of this Agreement, &#8220;<font style="font-weight: bold;">VAT</font>&#8221; means value added tax as provided for in the PRC&#8217;s Circular on the Nationwide Implementation of Pilot Program for the Collection of Value
        Added-Tax Instead of Business Tax.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The Representatives, on behalf of the several Underwriters, may, in their sole discretion, waive in writing the performance by the Company of any one or more of the foregoing covenants or extend the time for their
        performance.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">23</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 4.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Payment of Expenses</font>.&#160; The Company agrees to pay all costs, fees and expenses incurred in connection with the
        performance of its obligations hereunder and in connection with the transactions contemplated hereby, including without limitation (i) all expenses incident to the issuance, sale and delivery of the Offered Shares (including all printing and
        engraving costs), (ii) all fees and expenses of the registrar and transfer agent of the Ordinary Shares, (iii) all necessary Transfer Taxes in connection with the issuance and sale of the Offered Shares to the Underwriters, (v) all fees and
        expenses of the Company&#8217;s counsel, independent public or certified public accountants and other advisors, (vi) all costs and expenses incurred in connection with the preparation, printing, filing, shipping and distribution of the Registration
        Statement (including financial statements, exhibits, schedules, consents and certificates of experts), the Time of Sale Prospectus, the Prospectus, each free writing prospectus prepared by or on behalf of, used by, or referred to by the Company,
        and each preliminary prospectus, each Permitted Section 5(d) Communication, and all amendments and supplements thereto, and this Agreement, (vii) all filing fees, attorneys&#8217; fees and expenses incurred by the Company or the Underwriters in
        connection with qualifying or registering (or obtaining exemptions from the qualification or registration of) all or any part of the Offered Shares for offer and sale under the state securities or blue sky laws, and, if requested by the
        Representatives, preparing and printing a &#8220;Blue Sky Survey&#8221;, and any supplements thereto, advising the Underwriters of such qualifications, registrations and exemptions, (viii) the reasonable costs, fees and expenses incurred by the Underwriters in
        connection with determining their compliance with the rules and regulations of FINRA related to the Underwriters&#8217; participation in the offering and distribution of the Offered Shares, including any related filing fees (if any) and the legal fees
        of, and disbursements by, counsel to the Underwriters, (ix) the costs and expenses of the Company relating to investor presentations on any &#8220;road show&#8221;, any Permitted Section 5(d) Communication or any Section 5(d) Oral Communication undertaken in
        connection with the offering of the Offered Shares, including, without limitation, expenses associated with the preparation or dissemination of any electronic road show, expenses associated with the production of road show slides and graphics, fees
        and expenses of any consultants engaged in connection with the road show presentations with the prior approval of the Company, travel and lodging expenses of the representatives, employees and officers of the Company and any such consultants, and
        the cost of any aircraft chartered in connection with the road show, provided that the Company and the Underwriters shall each be responsible for 50% of the cost of any aircraft chartered in connection with the road show; and (ix) the fees and
        expenses associated with listing the Offered Shares on the Nasdaq. In addition, the Company shall reimburse the Representatives for out-of-pocket expenses (including fees and expenses of its counsel and any other independent experts retained by the
        Representatives) reasonably incurred by it in connection with the transactions contemplated hereby; provided that the Company shall not have any obligation to reimburse expenses exceeding $250,000 in the aggregate without the prior approval of the
        Company, except as otherwise agreed. Except as provided in this Section 4 or in Section 7, Section 9 or Section 10 hereof, the Underwriters shall pay their own expenses, including the fees and disbursements of their counsel.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 5.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Covenant of the Underwriters.</font>&#160; Each Underwriter severally and not jointly covenants with the Company not to take any
        action that would result in the Company being required to file with the Commission pursuant to Rule 433(d) under the Securities Act a free writing prospectus prepared by or on behalf of such Underwriter that otherwise would not, but for such
        actions, be required to be filed by the Company under Rule 433(d).</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 6.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Conditions of the Obligations of the Underwriters.</font>&#160; The respective obligations of the several Underwriters hereunder
        to purchase and pay for the Offered Shares as provided herein on the First Closing Date and, with respect to the Optional Shares, each Option Closing Date, shall be subject to the accuracy of the representations and warranties on the part of the
        Company set forth in Section 1 hereof as of the date hereof and as of the First Closing Date as though then made and, with respect to the Optional Shares, as of each Option Closing Date as though then made, to the timely performance by the Company
        of its covenants and other obligations hereunder, and to each of the following additional conditions:</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Comfort Letter</font><font style="font-weight: bold;">.</font>&#160; On the date hereof, the Representatives shall
        have received from Ernst &amp; Young Hua Ming LLP, independent registered public accountants for the Company, a letter dated the date hereof addressed to the Underwriters, in form and substance satisfactory to the Representatives, containing
        statements and information of the type ordinarily included in accountant&#8217;s &#8220;comfort letters&#8221; to underwriters, delivered according to Statement of Auditing Standards No. 72 (or any successor bulletin), with respect to the audited and unaudited
        financial statements and certain financial information contained in the Registration Statement, the Time of Sale Prospectus, and each free writing prospectus, if any.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">24</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Compliance with Registration Requirements; No Stop Order; No Objection from FINRA.</font>&#160; For the period from
        and after the date of this Agreement and through and including the First Closing Date and, with respect to any Optional Shares purchased after the First Closing Date, each Option Closing Date:</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company shall have filed the Prospectus with the Commission (including the information previously omitted from the Registration Statement pursuant to Rule 430B under the Securities Act) in the manner
        and within the time period required by Rule 424(b) under the Securities Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No stop order suspending the effectiveness of the Registration Statement or any post-effective amendment to the Registration Statement shall be in effect, and no proceedings for such purpose shall have
        been instituted or threatened by the Commission.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If a filing has been made with FINRA, FINRA shall have raised no objection to the fairness and reasonableness of the underwriting terms and arrangements.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">No Material Adverse Change or Ratings Agency Change</font><font style="font-weight: bold;">.</font>&#160; For the
        period from and after the date of this Agreement and through and including the First Closing Date and, with respect to any Optional Shares purchased after the First Closing Date, each Option Closing Date:</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;in the judgment of the Representatives there shall not have occurred any Material Adverse Change; and</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;there shall not have occurred any downgrading, nor shall any notice have been given of any intended or potential downgrading or of any review for a possible change that does not indicate the direction of
        the possible change, in the rating accorded any securities of the Company or any of its subsidiaries by any &#8220;nationally recognized statistical rating organization&#8221; as that term is used in Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Opinion of Counsel for the Company</font><font style="font-weight: bold;">.</font>&#160; On each of the First Closing
        Date and each Option Closing Date the Representatives shall have received the opinion of Maples and Calder (Hong Kong) LLP, Cayman Islands counsel for the Company, Skadden, Arps, Slate, Meagher &amp; Flom LLP, U.S. counsel for the Company, and Han
        Kun Law Offices, Chinese counsel for the Company, each dated as of such date, substantially in the form attached hereto as <u>Exhibit A</u>, <u>Exhibit B</u> and <u>Exhibit C</u>, respectively, and to such further effect as the Representatives
        shall reasonably request.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Opinion of Tax Counsel for the Company. </font>On each of the First Closing Date and each Option Closing Date,
        the Representatives shall have received the opinion of Skadden, Arps, Slate, Meagher &amp; Flom LLP, U.S. counsel for the Company with respect to tax matters, dated as of such date, substantially in the form attached hereto attached hereto as <u>Exhibit
          D</u> and to such further effect as the Representatives shall reasonably request.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Opinion of Intellectual Property Counsel for the Company</font>.&#160; On each of the First Closing Date and each
        Option Closing Date, the Representatives shall have received the opinion of Knobbe, Martens, Olson &amp; Bear, LLP, intellectual property counsel for the Company, dated as of such date, substantially in the form attached hereto as <u>Exhibit E</u>
        and to such further effect as the Representatives shall reasonably request.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Opinion of Counsel for the Underwriters</font><font style="font-weight: bold;">.</font>&#160; On each of the First
        Closing Date and each Option Closing Date the Representatives shall have received the opinion of Goodwin Procter LLP, U.S. counsel for the Underwriters, and Fangda Partners, Chinese counsel for the Underwriters in connection with the offer and sale
        of the Offered Shares, in form and substance satisfactory to the Underwriters, each dated as of such date, with executed copies for each of the other Underwriters named on the Prospectus cover page.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">25</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Officers&#8217; Certificate</font><font style="font-weight: bold;">.</font>&#160; On each of the First Closing Date and
        each Option Closing Date, the Representatives shall have received a certificate executed by the Chairman of the Board or the Chief Executive Officer of the Company and a principal financial or accounting officer of the Company, dated as of such
        date, to the effect set forth in Section 6(b)(ii) and further to the effect that:</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;for the period from and including the date of this Agreement through and including such date, there has not occurred any Material Adverse Change;</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the representations, warranties and covenants of the Company set forth in Section 1 of this Agreement are true and correct with the same force and effect as though expressly made on and as of such date;
        and</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company has complied with all the agreements hereunder and satisfied all the conditions on its part to be performed or satisfied hereunder at or prior to such date.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Bring-down Comfort Letter</font><font style="font-weight: bold;">.</font>&#160; On each of the First Closing Date and
        each Option Closing Date the Representatives shall have received from Ernst &amp; Young Hua Ming LLP, independent registered public accountants for the Company, a letter dated such date, in form and substance satisfactory to the Representatives,
        which letter shall:&#160; (i) reaffirm the statements made in the letter furnished by them pursuant to Section 6(a), except that the specified date referred to therein for the carrying out of procedures shall be no more than three business days prior to
        the First Closing Date or the applicable Option Closing Date, as the case may be; and (ii) cover certain financial information contained in the Prospectus.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Lock-Up Agreements.</font>&#160; On or prior to the date hereof, the Company shall have furnished to the
        Representatives an agreement in the form of <u>Exhibit F</u> hereto from each of the persons listed on <u>Exhibit G</u> hereto, and each such agreement shall be in full force and effect on each of the First Closing Date and each Option Closing
        Date.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(j)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Rule 462(b) Registration Statement</font>.&#160; In the event that a Rule 462(b) Registration Statement is filed in
        connection with the offering contemplated by this Agreement, such Rule 462(b) Registration Statement shall have been filed with the Commission on the date of this Agreement and shall have become effective automatically upon such filing.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(k)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Listing</font><font style="font-weight: bold;">.&#160; </font>On or prior to the date hereof, the Offered Shares
        shall have been approved for listing on the Nasdaq, subject to notice of issuance.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(l)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">CFO Certificate</font>. On the date of this Agreement and on the First Closing Date or the applicable Option
        Closing Date, as the case may be, the Company shall have furnished to the Representatives a certificate, dated the respective dates of delivery thereof and addressed to the Underwriters, of its chief financial officer with respect to certain
        financial data contained in the Time of Sale Prospectus and the Prospectus, providing &#8220;management comfort&#8221; with respect to such information, in form and substance reasonably satisfactory to the Representatives.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">26</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(m)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Additional Documents</font>.&#160; On or before each of the First Closing Date and each Option Closing Date, the
        Representatives and counsel for the Underwriters shall have received such information, documents and opinions as they may reasonably request for the purposes of enabling them to pass upon the issuance and sale of the Offered Shares as contemplated
        herein, or in order to evidence the accuracy of any of the representations and warranties, or the satisfaction of any of the conditions or agreements, herein contained; and all proceedings taken by the Company in connection with the issuance and
        sale of the Offered Shares as contemplated herein and in connection with the other transactions contemplated by this Agreement shall be satisfactory in form and substance to the Representatives and counsel for the Underwriters.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">If any condition specified in this Section 6 is not satisfied when and as required to be satisfied, this Agreement may be terminated by the Representatives by notice from the Representatives to the Company at any time
        on or prior to the First Closing Date and, with respect to the Optional Shares, at any time on or prior to the applicable Option Closing Date, which termination shall be without liability on the part of any party to any other party, except that
        Section 4, Section 7, Section 9 and Section 10 shall at all times be effective and shall survive such termination.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 7.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Reimbursement of Underwriters&#8217; Expenses.</font>&#160; If this Agreement is terminated by the Representatives pursuant to Section
        6, Section 11 or Section 12, or if the sale to the Underwriters of the Offered Shares on the First Closing Date is not consummated because of any refusal, inability or failure on the part of the Company to perform any agreement herein or to comply
        with any provision hereof, the Company agrees to reimburse the Representatives and the other Underwriters (or such Underwriters as have terminated this Agreement with respect to themselves), severally, upon demand for all out-of-pocket expenses
        that shall have been reasonably incurred by the Representatives and the Underwriters in connection with the proposed purchase and the offering and sale of the Offered Shares, including, but not limited to, reasonable fees and disbursements of
        counsel, printing expenses, travel expenses, postage, facsimile and telephone charges, except as otherwise agreed.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 8.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Effectiveness of this Agreement.</font>&#160; This Agreement shall become effective upon the execution and delivery hereof by the
        parties hereto.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 9.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Indemnification.</font></div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Indemnification of the Underwriters</font><font style="font-weight: bold;">.</font>&#160; The Company agrees to
        indemnify and hold harmless each Underwriter, its affiliates, directors, officers, employees and agents, and each person, if any, who controls any Underwriter within the meaning of the Securities Act or the Exchange Act against any loss, claim,
        damage, liability or expense, as incurred, to which such Underwriter or such affiliate, director, officer, employee, agent or controlling person may become subject, under the Securities Act, the Exchange Act, other federal or state statutory law or
        regulation, or the laws or regulations of foreign jurisdictions where Offered Shares have been offered or sold or at common law or otherwise (including in settlement of any litigation, if such settlement is effected with the written consent of the
        Company), insofar as such loss, claim, damage, liability or expense (or actions in respect thereof as contemplated below) arises out of or is based upon (i) any untrue statement or alleged untrue statement of a material fact contained in the
        Registration Statement, or any amendment to the Registration Statement, or the omission or alleged omission to state therein a material fact required to be stated in the Registration Statement or necessary to make the statements in the Registration
        Statement not misleading; or (ii) any untrue statement or alleged untrue statement of a material fact included in any preliminary prospectus, the Time of Sale Prospectus, any free writing prospectus that the Company has used, referred to or filed,
        or is required to file, pursuant to Rule 433(d) of the Securities Act, any Marketing Materials, any Section 5(d) Written Communication or the Prospectus (or any amendment or supplement to the foregoing), or the omission or alleged omission to state
        therein a material fact necessary in order to make the statements, in the light of the circumstances under which they were made, not misleading; or (iii) any act or failure to act or any alleged act or failure to act by any Underwriter in
        connection with, or relating in any manner to, the Offered Shares or the offering contemplated hereby, and which is included as part of or referred to in any loss, claim, damage, liability or action arising out of or based upon any matter covered
        by</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">27</font></div>
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      </div>
      <div>clause (i) or (ii) above; and to reimburse each Underwriter and each such affiliate, director, officer, employee, agent and controlling person for any and all expenses (including the fees and disbursements of counsel) as such expenses are
        incurred by such Underwriter or such affiliate, director, officer, employee, agent or controlling person in connection with investigating, defending, settling, compromising or paying any such loss, claim, damage, liability, expense or action; <font style="font-style: italic;">provided, however</font>, that the foregoing indemnity agreement shall not apply to any loss, claim, damage, liability or expense to the extent, but only to the extent, arising out of or based upon any untrue statement
        or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with information relating to any Underwriter furnished to the Company by the Representatives in writing expressly for use in the Registration
        Statement, any preliminary prospectus, the Time of Sale Prospectus, any such free writing prospectus, any Marketing Materials, any Section 5(d) Written Communication or the Prospectus (or any amendment or supplement thereto), it being understood
        and agreed that the only such information consists of the information described in Section 9(b) below.&#160; The indemnity agreement set forth in this Section 9(a) shall be in addition to any liabilities that the Company may otherwise have.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Indemnification of the Company, its Directors and Officers</font>.&#160; Each Underwriter agrees, severally and not
        jointly, to indemnify and hold harmless the Company, each of its directors, each of its officers who signed the Registration Statement and each person, if any, who controls the Company within the meaning of the Securities Act or the Exchange Act,
        against any loss, claim, damage, liability or expense, as incurred, to which the Company, or any such director, officer or controlling person may become subject, under the Securities Act, the Exchange Act, or other federal or state statutory law or
        regulation, or the laws or regulations of foreign jurisdictions where Offered Shares have been offered or sold or at common law or otherwise (including in settlement of any litigation, if such settlement is effected with the written consent of such
        Underwriter), insofar as such loss, claim, damage, liability or expense (or actions in respect thereof as contemplated below) arises out of or is based upon (i) any untrue statement or alleged untrue statement of a material fact contained in the
        Registration Statement, or any amendment to the Registration Statement, or the omission or alleged omission to state therein a material fact required to be stated in the Registration Statement or necessary to make the statements in the Registration
        Statement not misleading or (ii) any untrue statement or alleged untrue statement of a material fact included in any preliminary prospectus, the Time of Sale Prospectus, any free writing prospectus that the Company has used, referred to or filed,
        or is required to file, pursuant to Rule 433 of the Securities Act, any Section 5(d) Written Communication or the Prospectus (or any such amendment or supplement) or the omission or alleged omission to state therein a material fact necessary in
        order to make the statements, in the light of the circumstances under which they were made, not misleading, in each case to the extent, but only to the extent, that such untrue statement or alleged untrue statement or omission or alleged omission
        was made in the Registration Statement, such preliminary prospectus, the Time of Sale Prospectus, such free writing prospectus, such Section 5(d) Written Communication or the Prospectus (or any such amendment or supplement), in reliance upon and in
        conformity with information relating to such Underwriter furnished to the Company by the Representatives in writing expressly for use therein; and to reimburse the Company, or any such director, officer or controlling person for any and all
        expenses (including the fees and disbursements of counsel) as such expenses are incurred by the Company, or any such director, officer or controlling person in connection with investigating, defending, settling, compromising or paying any such
        loss, claim, damage, liability, expense or action.&#160; The Company hereby acknowledges that the only information that the Representatives have furnished to the Company expressly for use in the Registration Statement, any preliminary prospectus, the
        Time of Sale Prospectus, any free writing prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) of the Securities Act, any Section 5(d) Written Communication or the Prospectus (or any amendment or supplement to the
        foregoing) are the statements set forth in<font style="font-weight: bold;">&#160;</font>paragraphs under the caption &#8220;Underwriting&#8221; in the Preliminary Prospectus Supplement and the Final Prospectus Supplement. The indemnity agreement set forth in this
        Section 9(b) shall be in addition to any liabilities that each Underwriter may otherwise have.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">28</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Notifications and Other Indemnification Procedures</font><font style="font-weight: bold;">.</font>&#160; Promptly
        after receipt by an indemnified party under this Section 9 of notice of the commencement of any action, such indemnified party will, if a claim in respect thereof is to be made against an indemnifying party under this Section 9, notify the
        indemnifying party in writing of the commencement thereof, but the omission to so notify the indemnifying party will not relieve the indemnifying party from any liability which it may have to any indemnified party to the extent the indemnifying
        party is not materially prejudiced as a proximate result of such failure and shall not in any event relieve the indemnifying party from any liability that it may have otherwise than on account of this indemnity agreement.&#160; In case any such action
        is brought against any indemnified party and such indemnified party seeks or intends to seek indemnity from an indemnifying party, the indemnifying party will be entitled to participate in, and, to the extent that it shall elect, jointly with all
        other indemnifying parties similarly notified, by written notice delivered to the indemnified party promptly after receiving the aforesaid notice from such indemnified party, to assume the defense thereof with counsel reasonably satisfactory to
        such indemnified party; <font style="font-style: italic;">provided, however</font>, that if the defendants in any such action include both the indemnified party and the indemnifying party and the indemnified party shall have reasonably concluded
        that a conflict may arise between the positions of the indemnifying party and the indemnified party in conducting the defense of any such action or that there may be legal defenses available to it and/or other indemnified parties which are
        different from or additional to those available to the indemnifying party, the indemnified party or parties shall have the right to select separate counsel to assume such legal defenses and to otherwise participate in the defense of such action on
        behalf of such indemnified party or parties.&#160; Upon receipt of notice from the indemnifying party to such indemnified party of such indemnifying party&#8217;s election to so assume the defense of such action and approval by the indemnified party of
        counsel, the indemnifying party will not be liable to such indemnified party under this Section 9 for any legal or other expenses subsequently incurred by such indemnified party in connection with the defense thereof unless (i) the indemnified
        party shall have employed separate counsel in accordance with the proviso to the preceding sentence (it being understood, however, that the indemnifying party shall not be liable for the fees and expenses of more than one separate counsel (together
        with local counsel), representing the indemnified parties who are parties to such action), which counsel (together with any local counsel) for the indemnified parties shall be selected by BofA (in the case of counsel for the indemnified parties
        referred to in Section 9(a) above) or by the Company (in the case of counsel for the indemnified parties referred to in Section 9(b) above)) or (ii) the indemnifying party shall not have employed counsel satisfactory to the indemnified party to
        represent the indemnified party within a reasonable time after notice of commencement of the action or (iii) the indemnifying party has authorized in writing the employment of counsel for the indemnified party at the expense of the indemnifying
        party, in each of which cases the fees and expenses of counsel shall be at the expense of the indemnifying party and shall be paid as they are incurred.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; font-style: italic;">Settlements</font><font style="font-weight: bold;">.</font>&#160; The indemnifying party under this Section 9 shall
        not be liable for any settlement of any proceeding effected without its written consent, but if settled with such consent or if there be a final judgment for the plaintiff, the indemnifying party agrees to indemnify the indemnified party against
        any loss, claim, damage, liability or expense by reason of such settlement or judgment.&#160; Notwithstanding the foregoing sentence, if at any time an indemnified party shall have requested an indemnifying party to reimburse the indemnified party for
        fees and expenses of counsel as contemplated by Section 9(c) hereof, the indemnifying party shall be liable for any settlement of any proceeding effected without its written consent if (i) such settlement is entered into more than 30 days after
        receipt by such indemnifying party of the aforesaid request and (ii) such indemnifying party shall not have reimbursed the indemnified party in accordance with such request prior to the date of such settlement.&#160; No indemnifying party shall, without
        the prior written consent of the indemnified party, effect any settlement, compromise or consent to the entry of judgment in any pending or threatened action, suit or proceeding in respect of which any indemnified party is or could have been a
        party and indemnity was or could have been sought hereunder by such indemnified party, unless such settlement, compromise or consent includes an unconditional release of such indemnified party from all liability on claims that are the subject
        matter of such action, suit or proceeding and does not include an admission of fault or culpability or a failure to act by or on behalf of such indemnified party.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">29</font></div>
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      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 10.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Contribution.</font>&#160; If the indemnification provided for in Section 9 is for any reason held to be unavailable to or
        otherwise insufficient to hold harmless an indemnified party in respect of any losses, claims, damages, liabilities or expenses referred to therein, then each indemnifying party shall contribute to the aggregate amount paid or payable by such
        indemnified party, as incurred, as a result of any losses, claims, damages, liabilities or expenses referred to therein (i) in such proportion as is appropriate to reflect the relative benefits received by the Company, on the one hand, and the
        Underwriters, on the other hand, from the offering of the Offered Shares pursuant to this Agreement or (ii) if the allocation provided by clause (i) above is not permitted by applicable law, in such proportion as is appropriate to reflect not only
        the relative benefits referred to in clause (i) above but also the relative fault of the Company, on the one hand, and the Underwriters, on the other hand, in connection with the statements or omissions which resulted in such losses, claims,
        damages, liabilities or expenses, as well as any other relevant equitable considerations.&#160; The relative benefits received by the Company, on the one hand, and the Underwriters, on the other hand, in connection with the offering of the Offered
        Shares pursuant to this Agreement shall be deemed to be in the same respective proportions as the total proceeds from the offering of the Offered Shares pursuant to this Agreement (before deducting expenses) received by the Company, and the total
        underwriting discounts and commissions received by the Underwriters, in each case as set forth on the front cover page of the Prospectus, bear to the aggregate initial public offering price of the Offered Shares as set forth on such cover.&#160; The
        relative fault of the Company, on the one hand, and the Underwriters, on the other hand, shall be determined by reference to, among other things, whether any such untrue or alleged untrue statement of a material fact or omission or alleged omission
        to state a material fact relates to information supplied by the Company, on the one hand, or the Underwriters, on the other hand, and the parties&#8217; relative intent, knowledge, access to information and opportunity to correct or prevent such
        statement or omission.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The amount paid or payable by a party as a result of the losses, claims, damages, liabilities and expenses referred to above shall be deemed to include, subject to the limitations set forth in Section 9(c), any legal
        or other fees or expenses reasonably incurred by such party in connection with investigating or defending any action or claim.&#160; The provisions set forth in Section 9(c) with respect to notice of commencement of any action shall apply if a claim for
        contribution is to be made under this Section 10; <font style="font-style: italic;">provided, however,</font> that no additional notice shall be required with respect to any action for which notice has been given under Section 9(c) for purposes of
        indemnification.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">The Company and the Underwriters agree that it would not be just and equitable if contribution pursuant to this Section 10 were determined by pro rata allocation (even if the Underwriters were treated as one entity for
        such purpose) or by any other method of allocation which does not take account of the equitable considerations referred to in this Section 10.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">Notwithstanding the provisions of this Section 10, no Underwriter shall be required to contribute any amount in excess of the underwriting discounts and commissions received by such Underwriter in connection with the
        Offered Shares underwritten by it and distributed to the public.&#160; No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of
        such fraudulent misrepresentation.&#160; The Underwriters&#8217; obligations to contribute pursuant to this Section 10 are several, and not joint, in proportion to their respective underwriting commitments as set forth opposite their respective names on <u>Schedule
          A</u>.&#160; For purposes of this Section 10, each affiliate, director, officer, employee and agent of an Underwriter and each person, if any, who controls an Underwriter within the meaning of the Securities Act or the Exchange Act shall have the same
        rights to contribution as such Underwriter, and each director of the Company, each officer of the Company who signed the Registration Statement, and each person, if any, who controls the Company within the meaning of the Securities Act and the
        Exchange Act shall have the same rights to contribution as the Company.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">30</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 11.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Default of One or More of the Several Underwriters</font><font style="font-weight: bold; font-style: italic;">.</font>&#160; If,
        on the First Closing Date or any Option Closing Date any one or more of the several Underwriters shall fail or refuse to purchase Offered Shares that it or they have agreed to purchase hereunder on such date, and the aggregate number of Offered
        Shares which such defaulting Underwriter or Underwriters agreed but failed or refused to purchase does not exceed 10% of the aggregate number of the Offered Shares to be purchased on such date, the Representatives may make arrangements satisfactory
        to the Company for the purchase of such Offered Shares by other persons, including any of the Underwriters, but if no such arrangements are made by such date, the other Underwriters shall be obligated, severally and not jointly, in the proportions
        that the number of Firm Shares set forth opposite their respective names on <u>Schedule A</u> bears to the aggregate number of Firm Shares set forth opposite the names of all such non-defaulting Underwriters, or in such other proportions as may be
        specified by the Representatives with the consent of the non-defaulting Underwriters, to purchase the Offered Shares which such defaulting Underwriter or Underwriters agreed but failed or refused to purchase on such date. If, on the First Closing
        Date or any Option Closing Date any one or more of the Underwriters shall fail or refuse to purchase Offered Shares and the aggregate number of Offered Shares with respect to which such default occurs exceeds 10% of the aggregate number of Offered
        Shares to be purchased on such date, and arrangements satisfactory to the Representatives and the Company for the purchase of such Offered Shares are not made within 48 hours after such default, this Agreement shall terminate without liability of
        any party to any other party except that the provisions of Section 4, Section 7, Section 9 and Section 10 shall at all times be effective and shall survive such termination.&#160; In any such case either the Representatives or the Company shall have the
        right to postpone the First Closing Date or the applicable Option Closing Date, as the case may be, but in no event for longer than seven days in order that the required changes, if any, to the Registration Statement and the Prospectus or any other
        documents or arrangements may be effected.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">As used in this Agreement, the term &#8220;<font style="font-weight: bold;">Underwriter</font>&#8221; shall be deemed to include any person substituted for a defaulting Underwriter under this Section 11.&#160; Any action taken under
        this Section 11 shall not relieve any defaulting Underwriter from liability in respect of any default of such Underwriter under this Agreement.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 12.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Termination of this Agreement</font><font style="font-weight: bold; font-style: italic;">.</font>&#160; Prior to the purchase of
        the Firm Shares by the Underwriters on the First Closing Date, this Agreement may be terminated by the Representatives by notice given to the Company if at any time: (i) trading or quotation in any of the Company&#8217;s securities shall have been
        suspended or limited by the Commission or by Nasdaq, or trading in securities generally on either the Nasdaq or the New York Stock Exchange shall have been suspended or limited, or minimum or maximum prices shall have been generally established on
        any of such stock exchanges; (ii) a general banking moratorium shall have been declared by any of federal, New York, or PRC authorities; (iii) there shall have occurred any outbreak or escalation of national or international hostilities or any
        crisis or calamity, or any change in the United States or international financial markets, or any substantial change or development involving a prospective substantial change in United States&#8217; or international political, financial or economic
        conditions, as in the judgment of the Representatives is material and adverse and makes it impracticable to market the Offered Shares in the manner and on the terms described in the Time of Sale Prospectus or the Prospectus or to enforce contracts
        for the sale of securities; (iv) in the judgment of the Representatives there shall have occurred any Material Adverse Change; or (v) the Company shall have sustained a loss by strike, fire, flood, earthquake, accident or other calamity of such
        character as in the judgment of the Representatives may interfere materially with the conduct of the business and operations of the Company regardless of whether or not such loss shall have been insured.&#160; Any termination pursuant to this Section 12
        shall be without liability on the part of (a) the Company to any Underwriter, except that the Company shall be obligated to reimburse the expenses of the Representatives and the Underwriters pursuant to Section 4 or Section 7 hereof or (b) any
        Underwriter to the Company; <font style="font-style: italic;">provided, however,</font> that the provisions of Section 9 and Section 10 shall at all times be effective and shall survive such termination.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">31</font></div>
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      </div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 13.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">No Advisory or Fiduciary Relationship.</font>&#160; The Company acknowledges and agrees that (a) the purchase and sale of the
        Offered Shares pursuant to this Agreement, including the determination of the public offering price of the Offered Shares and any related discounts and commissions, is an arm&#8217;s-length commercial transaction between the Company, on the one hand, and
        the several Underwriters, on the other hand, (b) in connection with the offering contemplated hereby and the process leading to such transaction, each Underwriter is and has been acting solely as a principal and is not the agent or fiduciary of the
        Company, or its stockholders, or its creditors, employees or any other party, (c) no Underwriter has assumed or will assume an advisory or fiduciary responsibility in favor of the Company with respect to the offering contemplated hereby or the
        process leading thereto (irrespective of whether such Underwriter has advised or is currently advising the Company on other matters) and no Underwriter has any obligation to the Company with respect to the offering contemplated hereby except the
        obligations expressly set forth in this Agreement, (d) the Underwriters and their respective affiliates may be engaged in a broad range of transactions that involve interests that differ from those of the Company, and (e) the Underwriters have not
        provided any legal, accounting, regulatory or tax advice with respect to the offering contemplated hereby and the Company has consulted its own legal, accounting, regulatory and tax advisors to the extent it deemed appropriate.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 14.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Representations and Indemnities to Survive Delivery</font><font style="font-weight: bold; font-style: italic;">.</font>&#160; The
        respective indemnities, agreements, representations, warranties and other statements of the Company, of its officers and of the several Underwriters set forth in or made pursuant to this Agreement will remain in full force and effect, regardless of
        any investigation made by or on behalf of any Underwriter or the Company or any of its or their partners, officers or directors or any controlling person, as the case may be, and, anything herein to the contrary notwithstanding, will survive
        delivery of and payment for the Offered Shares sold hereunder and any termination of this Agreement.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 15.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Notices.</font>&#160; All communications hereunder shall be in writing and shall be mailed, hand delivered or telecopied and
        confirmed to the parties hereto as follows:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4410ecf2de9e40b9a43f6a0945cb1fbf" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 144pt; vertical-align: top; align: right;">If to the Representatives:</td>
            <td style="width: auto; vertical-align: top;">
              <div>BofA Securities, Inc.</div>
            </td>
          </tr>

      </table>
      <div style="margin-left: 180pt;">One Bryant Park</div>
      <div style="margin-left: 180pt;">New York, New York 10036</div>
      <div style="margin-left: 180pt;">Facsimile: (646) 855-3073</div>
      <div style="margin-left: 180pt;">Attention: Syndicate Department</div>
      <div style="margin-left: 180pt;">With a copy to:</div>
      <div style="margin-left: 180pt;">Facsimile: (212) 230-8730</div>
      <div style="margin-left: 180pt;">Attention: ECM Legal</div>
      <div><br>
      </div>
      <div style="margin-left: 180pt;">Jefferies LLC</div>
      <div style="margin-left: 180pt;">520 Madison Avenue</div>
      <div style="margin-left: 180pt;">New York, New York 10022</div>
      <div style="margin-left: 180pt;">Facsimile: (646) 619-4437</div>
      <div style="margin-left: 180pt;">Attention:&#160; General Counsel</div>
      <div><br>
      </div>
      <div style="margin-left: 180pt;">Evercore Group L.L.C.</div>
      <div style="margin-left: 180pt;">55 East 52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street</div>
      <div style="margin-left: 180pt;">New York, New York 10055</div>
      <div style="margin-left: 180pt;">Attention: Kenneth A. Masotti, Esq.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">32</font></div>
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      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb7448bebd9e14849b0d2715b200571c5" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 144pt; vertical-align: top; align: right;">with a copy to:</td>
            <td style="width: auto; vertical-align: top;">
              <div>Goodwin Procter LLP</div>
            </td>
          </tr>

      </table>
      <div style="text-indent: 0pt; margin-left: 180pt;">620 Eighth Avenue</div>
      <div style="text-indent: 0pt; margin-left: 180pt;">New York, New York 10018</div>
      <div style="text-indent: 0pt; margin-left: 180pt;">Facsimile: (646) 558-4145</div>
      <div style="margin-left: 180pt;">Attention: Michael Maline and Benjamin Marsh</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z831f108c68f740fb888be46363183187" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 144pt; vertical-align: top; align: right;">If to the Company:</td>
            <td style="width: auto; vertical-align: top;">
              <div>BeyondSpring Inc.</div>
            </td>
          </tr>

      </table>
      <div style="text-indent: 0pt; margin-left: 180pt;">28 Liberty Street, 39<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor</div>
      <div style="text-indent: 0pt; margin-left: 180pt;">New York, New York 10005</div>
      <div style="margin-left: 180pt;">Attention:&#160; Finance Department</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za93c8f5bc57f4f4d966713bb6a18522f" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 144pt; vertical-align: top; align: right;">with a copy to:</td>
            <td style="width: auto; vertical-align: top;">
              <div>Skadden, Arps, Slate, Meagher &amp; Flom LLP</div>
            </td>
          </tr>

      </table>
      <div style="text-indent: 0pt; margin-left: 180pt;">One Manhattan West</div>
      <div style="margin-left: 180pt;">New York, New York 10001</div>
      <div style="margin-left: 180pt;">Attention: Andrea L. Nicol&#225;s</div>
      <div><br>
      </div>
      <div>Any party hereto may change the address for receipt of communications by giving written notice to the others.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 16.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Successors</font><font style="font-weight: bold; font-style: italic;">.</font>&#160; This Agreement will inure to the benefit of
        and be binding upon the parties hereto, including any substitute Underwriters pursuant to Section 11 hereof, and to the benefit of the affiliates, directors, officers, employees, agents and controlling persons referred to in Section 9 and Section
        10, and in each case their respective successors, and no other person will have any right or obligation hereunder.&#160; The term &#8220;successors&#8221; shall not include any purchaser of the Offered Shares as such from any of the Underwriters merely by reason of
        such purchase.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 17.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Partial Unenforceability.</font>&#160; The invalidity or unenforceability of any section, paragraph or provision of this
        Agreement shall not affect the validity or enforceability of any other section, paragraph or provision hereof.&#160; If any section, paragraph or provision of this Agreement is for any reason determined to be invalid or unenforceable, there shall be
        deemed to be made such minor changes (and only such minor changes) as are necessary to make it valid and enforceable.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 18.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Recognition of the U.S. Special Resolution Regimes.</font></div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In the event that any Underwriter that is a Covered Entity becomes subject to a proceeding under a U.S. Special Resolution Regime, the transfer from such Underwriter
        of this Agreement, and any interest and obligation in or under this Agreement, will be effective to the same extent as the transfer would be effective under the U.S. Special Resolution Regime if this Agreement, and any such interest and obligation,
        were governed by the laws of the United States or a state of the United States.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In the event that any Underwriter that is a Covered Entity or a BHC Act Affiliate of such Underwriter becomes subject to a proceeding under a U.S. Special Resolution
        Regime, Default Rights under this Agreement that may be exercised against such Underwriter are permitted to be exercised to no greater extent than such Default Rights could be exercised under the U.S. Special Resolution Regime if this Agreement
        were governed by the laws of the United States or a state of the United States.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">33</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
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      </div>
      <div><br>
      </div>
      <div>For purposes of this Agreement, (A) &#8220;<font style="font-weight: bold;">BHC Act Affiliate</font>&#8221; has the meaning assigned to the term &#8220;affiliate&#8221; in, and shall be interpreted in accordance with, 12 U.S.C. &#167; 1841(k); (B) &#8220;<font style="font-weight: bold;">Covered Entity</font>&#8221; means any of the following: (i) a &#8220;covered entity&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167; 252.82(b); (ii) a &#8220;covered bank&#8221; as that term is defined in, and interpreted in
        accordance with, 12 C.F.R. &#167; 47.3(b); or (iii) a &#8220;covered FSI&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167; 382.2(b); (C) &#8220;<font style="font-weight: bold;">Default Right</font>&#8221; has the meaning assigned to that term
        in, and shall be interpreted in accordance with, 12 C.F.R. &#167;&#167; 252.81, 47.2 or 382.1, as applicable; and (D) &#8220;<font style="font-weight: bold;">U.S. Special Resolution Regime</font>&#8221; means each of (i) the Federal Deposit Insurance Act and the
        regulations promulgated thereunder and (ii) Title II of the Dodd-Frank Wall Street Reform and Consumer Protection Act and the regulations promulgated thereunder.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 19.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Governing Law Provisions; Currency Provisions<font style="font-style: italic;">.</font></font></div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;This Agreement shall be governed by and construed in accordance with the internal laws of the State of New York applicable to agreements made and to be performed in
        such state.&#160; Any legal suit, action or proceeding arising out of or based upon this Agreement or the transactions contemplated hereby (&#8220;Related Proceedings&#8221;) may be instituted in the federal courts of the United States of America located in the
        Borough of Manhattan in the City of New York or the courts of the State of New York in each case located in the Borough of Manhattan in the City of New York (collectively, the &#8220;<font style="font-weight: bold;">Specified Courts</font>&#8221;), and each
        party irrevocably submits to the exclusive jurisdiction (except for proceedings instituted in regard to the enforcement of a judgment of any such court (a &#8220;<font style="font-weight: bold;">Related Judgment</font>&#8221;), as to which such jurisdiction is
        non-exclusive) of such courts in any such suit, action or proceeding.&#160; Service of any process, summons, notice or document by mail to such party&#8217;s address set forth above shall be effective service of process for any suit, action or other
        proceeding brought in any such court.&#160; The parties irrevocably and unconditionally waive any objection to the laying of venue of any suit, action or other proceeding in the Specified Courts and irrevocably and unconditionally waive and agree not to
        plead or claim in any such court that any such suit, action or other proceeding brought in any such court has been brought in an inconvenient forum.&#160; The Company and each other party not located in the United States has irrevocably appointed CT
        Corporation System, which currently maintains a New York City office at 111 Eighth Avenue, New York, New York 10011, United States of America, as its agent to receive service of process or other legal summons for purposes of any such suit, action
        or proceeding that may be instituted in any state or federal court in the Borough of Manhattan in the City of New York, United States of America.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;With respect to any Related Proceeding, each party irrevocably waives, to the fullest extent permitted by applicable law, all immunity (whether on the basis of
        sovereignty or otherwise) from jurisdiction, service of process, attachment (both before and after judgment) and execution to which it might otherwise be entitled in the Specified Courts, and with respect to any Related Judgment, each party waives
        any such immunity in the Specified Courts or any other court of competent jurisdiction, and will not raise or claim or cause to be pleaded any such immunity at or in respect of any such Related Proceeding or Related Judgment, including, without
        limitation, any immunity pursuant to the United States Foreign Sovereign Immunities Act of 1976, as amended.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The obligations of the Company pursuant to this Agreement in respect of any sum due to any Underwriter shall, notwithstanding any judgment in a currency other than
        United States dollars, not be discharged until the first business day, following receipt by any Underwriter of any sum adjudged to be so due in such other currency, on which such Underwriter may in accordance with normal banking procedures purchase
        United States dollars with such other currency.&#160; If the United States dollars so purchased are less than the sum originally due to such Underwriter in United States dollars hereunder, the Company agrees as a separate obligation and notwithstanding
        any such judgment, to indemnify such Underwriter against such loss.&#160; If the United States dollars so purchased are greater than the sum originally due to such Underwriter hereunder, such Underwriter agrees to pay to the Company an amount equal to
        the excess of the dollars so purchased over the sum originally due to such Underwriter hereunder.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">34</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;All payments made by the Company under this Agreement, if any, will be made without withholding or deduction for or on account of any present or future taxes,
        duties, assessments or governmental charges of whatever nature (other than taxes on net income) imposed or levied by or on behalf of the Cayman Islands or the PRC or any political subdivision or any taxing authority thereof or therein unless the
        Company is or becomes required by law to withhold or deduct such taxes, duties, assessments or other governmental charges.&#160; In such event, the Company will pay such additional amounts as will result, after such withholding or deduction, in the
        receipt by each Underwriter and each person controlling any Underwriter, as the case may be, of the amounts that would otherwise have been receivable in respect thereof.</div>
      <div><br>
      </div>
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">Section 20.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">General Provisions.</font></div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;This Agreement constitutes the entire agreement of the parties to this Agreement and supersedes all prior written or oral and all contemporaneous oral agreements,
        understandings and negotiations with respect to the subject matter hereof.&#160; This Agreement may be executed in two or more counterparts, each one of which shall be an original, with the same effect as if the signatures thereto and hereto were upon
        the same instrument.&#160; This Agreement may not be amended or modified unless in writing by all of the parties hereto, and no condition herein (express or implied) may be waived unless waived in writing by each party whom the condition is meant to
        benefit.&#160; The section headings herein are for the convenience of the parties only and shall not affect the construction or interpretation of this Agreement.</div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Each of the parties hereto acknowledges that it is a sophisticated business person who was adequately represented by counsel during negotiations regarding the
        provisions hereof, including, without limitation, the indemnification provisions of Section 9 and the contribution provisions of Section 10, and is fully informed regarding said provisions.&#160; Each of the parties hereto further acknowledges that the
        provisions of Section 9 and Section 10 hereof fairly allocate the risks in light of the ability of the parties to investigate the Company, its affairs and its business in order to assure that adequate disclosure has been made in the Registration
        Statement, any preliminary prospectus, the Time of Sale Prospectus, each free writing prospectus and the Prospectus (and any amendments and supplements to the foregoing), as contemplated by the Securities Act and the Exchange Act.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">35</font></div>
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          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">If the foregoing is in accordance with your understanding of our agreement, kindly sign and return to the Company the enclosed copies hereof, whereupon this instrument, along with all counterparts hereof, shall become
        a binding agreement in accordance with its terms.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="ze2882516e334465badf79c54b4fc9bd9" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Very truly yours,</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">BEYONDSPRING INC.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="font-family: 'Times New Roman', Times, serif;">By: <br>
              </div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-family: 'Times New Roman', Times, serif;">/s/ Lan Huang</font> <br>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Name: Lan Huang</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Title:&#160;&#160; CEO</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-indent: 72pt;">The foregoing Underwriting Agreement is hereby confirmed and accepted by the Representatives in New York, New York as of the date first above written.</div>
      <div><br>
      </div>
      <div style="font-weight: bold;">BOFA SECURITIES, INC.</div>
      <div style="font-weight: bold;">JEFFERIES LLC</div>
      <div style="font-weight: bold;">EVERCORE GROUP L.L.C.</div>
      <div>Acting individually and as Representatives</div>
      <div>of the several Underwriters named in</div>
      <div>the attached Schedule A.</div>
      <div><br>
      </div>
      <div style="font-weight: bold;">BOFA SECURITIES, INC.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z8abd86f7498a41c88f1cc1616d9a0d3d" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">/s/ Arvind Kush</div>
            </td>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Name: Arvind Kush</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Title:&#160;&#160; Managing Director</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="font-weight: bold;">JEFFERIES LLC</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zd5d91d24d91349778f72a5aabd95dc1f" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">/s/ Dustin Tyner</div>
            </td>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Name: Dustin Tyner</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Title:&#160;&#160; Managing Director</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="font-weight: bold;">EVERCORE GROUP L.L.C.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z984c599830d54c27ae2281888e1756ba" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">/s/ Maren Winnick</div>
            </td>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Name: Maren Winnick</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Title:&#160;&#160; Senior Managing Director</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;">36</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Schedule A</div>
      <div style="text-align: right; font-weight: bold;"> <br>
      </div>
      <table id="zd0f69da49ab54352b1cb006af1d3b6ac" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="vertical-align: bottom;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Underwriters</div>
            </td>
            <td colspan="1" style="vertical-align: bottom;" valign="bottom">&#160;</td>
            <td colspan="2" style="vertical-align: bottom;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Number of</div>
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Firm Shares</div>
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">to be Purchased</div>
            </td>
            <td colspan="1" style="vertical-align: bottom;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: bottom; width: 88%; background-color: #CCEEFF;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">BofA Securities, Inc.</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">2,775,000</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: bottom; width: 88%;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">Jefferies LLC</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; width: 1%;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">2,325,000</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: bottom; width: 88%; background-color: #CCEEFF;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">Evercore Group L.L.C.</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">2,025,000</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: bottom; width: 88%; padding-bottom: 1px;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">H.C. Wainwright &amp; Co., LLC</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 1px;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: #000000 solid 1px;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 1px;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">375,000</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 1px;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: bottom; width: 88%; padding-bottom: 2px; background-color: #CCEEFF;" valign="bottom">
              <div style="text-indent: 0pt; margin-left: 36pt; font-family: 'Times New Roman', Times, serif;">Total</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" valign="bottom">&#160;</td>
            <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" valign="bottom">
              <div style="font-family: 'Times New Roman', Times, serif;">7,500,000</div>
            </td>
            <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">&#160;</td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Schedule B</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Free Writing Prospectuses Included in the Time of Sale Prospectus</u></div>
      <div><br>
      </div>
      <div>None.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Schedule C</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Permitted Section 5(d) Communications</u></div>
      <div><br>
      </div>
      <div>None.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%A-%%-->
      <div style="text-align: right; font-weight: bold;">Exhibit A</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Opinion of Cayman Islands Company Counsel</u></div>
      <div><br>
      </div>
      <div style="text-align: center;">Attached.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">A-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%B-%%-->
      <div style="text-align: right; font-weight: bold;">Exhibit B</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Opinion of Chinese Company Counsel</u></div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Attached.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">B-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%C-%%-->
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">EXHIBIT C</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Opinion of U.S. Company Counsel</u></div>
      <div><br>
      </div>
      <div style="text-align: center;">Attached.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">C-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%D-%%-->
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">EXHIBIT D</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Tax Opinion of U.S. Company Counsel</u></div>
      <div><br>
      </div>
      <div style="text-align: center;">Attached.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">D-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%E-%%-->
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">EXHIBIT E</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Opinion of Intellectual Property Company Counsel</u></div>
      <div><br>
      </div>
      <div style="text-align: center;">Attached.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">E-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%F-%%-->
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Exhibit F</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;"><u>Form of Lock-up Agreement</u></div>
      <div><br>
      </div>
      <div>November __, 2020</div>
      <div><br>
      </div>
      <div>BofA Securities, Inc.</div>
      <div>Jefferies LLC</div>
      <div>Evercore Group L.L.C.</div>
      <div style="margin-left: 36pt;">As Representatives of the several Underwriters</div>
      <div><br>
      </div>
      <div>c/o BofA Securities, Inc.</div>
      <div>One Bryant Park</div>
      <div>New York, New York 10036</div>
      <div><br>
      </div>
      <div>c/o Jefferies LLC</div>
      <div>520 Madison Avenue</div>
      <div>New York, New York 10022</div>
      <div><br>
      </div>
      <div>c/o Evercore Group L.L.C.</div>
      <div>55 East 52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street</div>
      <div>New York, New York 10055</div>
      <div><br>
      </div>
      <div>RE:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;BeyondSpring Inc. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;)</div>
      <div><br>
      </div>
      <div>Ladies &amp; Gentlemen:</div>
      <div><br>
      </div>
      <div>The undersigned is a record or beneficial owner of ordinary shares, par value $0.0001 per share, of the Company (&#8220;<font style="font-weight: bold;">Ordinary Shares</font>&#8221;) or of securities convertible into or exchangeable or exercisable for
        Ordinary Shares.&#160; The Company proposes to conduct a public offering of Ordinary Shares (the &#8220;<font style="font-weight: bold;">Offering</font>&#8221;) for which BofA Securities, Inc. (&#8220;<font style="font-weight: bold;">BofA</font>&#8221;), Jefferies LLC (&#8220;<font style="font-weight: bold;">Jefferies</font>&#8221;) and Evercore Group L.L.C. (&#8220;<font style="font-weight: bold;">Evercore</font>&#8221;) will act as the representatives of the underwriters.&#160; The undersigned recognizes that the Offering will benefit each of
        the Company and the undersigned.&#160; The undersigned acknowledges that the underwriters are relying on the representations and agreements of the undersigned contained in this letter agreement in conducting the Offering and, at a subsequent date, in
        entering into an underwriting agreement (the &#8220;<font style="font-weight: bold;">Underwriting Agreement</font>&#8221;) and other underwriting arrangements with the Company with respect to the Offering.</div>
      <div><br>
      </div>
      <div>Annex A sets forth definitions for capitalized terms used in this letter agreement that are not defined in the body of this agreement.&#160; Those definitions are a part of this agreement.</div>
      <div><br>
      </div>
      <div>In consideration of the foregoing, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the undersigned hereby agrees that, during the Lock-up Period, the undersigned will not (and will
        cause any Family Member not to), without the prior written consent of BofA, Jefferies and Evercore, which may withhold their consent in their sole discretion:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc237534e53854a62a03432b8b7400bf5" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Sell or Offer to Sell any Ordinary Shares or Related Securities currently or hereafter owned either of record or beneficially (as defined in Rule 13d-3 under the Exchange Act) by the undersigned or such Family Member,</div>
            </td>
          </tr>

      </table>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4471c286dffb4239a5d9968c773d13ec" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>enter into any Swap,</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6e66825fb1ea4b3482db4fb7ad6aca60" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>make any demand for, or exercise any right with respect to, the registration under the Securities Act of the offer and sale of any Ordinary Shares or Related Securities, or cause to be filed a registration statement, prospectus or
                prospectus supplement (or an amendment or supplement thereto) with respect to any such registration, or</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf9a3a66fa4a146b39a8d9b7cb1041e44" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>publicly announce any intention to do any of the foregoing.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>The foregoing will not apply to the registration of the offer and sale of the Offered Shares, and the sale of the Offered Shares to the underwriters, in each case as contemplated by the Underwriting Agreement.&#160; In addition, the foregoing
        restrictions shall not apply to:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z70aaf8bf58fb4aafa0ae6012173c7aa2" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a bona fide gift or gifts or by will or intestacy, provided that (i) the donee(s) or transferee(s) thereof agree to be bound in writing by the restrictions set forth herein, (ii) any such transfer shall not involve a disposition for
                value and (iii) no public disclosures or filing reporting a reduction in beneficial ownership of shares of Ordinary Shares shall be required, or made voluntarily, during the Lock-Up Period,</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3c75de9a23454ee09ceb6d324f36a6be" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>any member of the immediate family of the undersigned or any trust or other legal entity for the direct or indirect benefit of the undersigned or the immediate family of the undersigned, provided that (i) the transferee agrees to be
                bound in writing by the restrictions set forth herein, and (ii) no public disclosures or filing reporting a reduction in beneficial ownership of shares of Ordinary Shares shall be required, or made voluntarily, during the Lock-Up Period,</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zebfb9cf6ded84a699321f12d33c5c7d2" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares to the Company upon the vesting or exercise of an option or other award granted under a share incentive plan or share purchase plan of the Company described in the Prospectus (as defined in the Underwriting
                Agreement) (by way of &#8220;net&#8221; exercise in accordance with their terms, and/or to cover withholding tax obligations in connection with such exercise, but for the avoidance of doubt, excluding all manners of exercise that would involve a sale
                to a third party of any securities, whether to cover the applicable aggregate exercise price, withholding tax obligations or otherwise), provided that any such Ordinary Shares received upon such vesting or exercise shall be subject to the
                terms of this letter agreement;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2088fb0124324a9abeb4d778c4db62fc" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares to the Company, or the withholding of Ordinary Shares by the Company, solely in connection with the payment of taxes due with respect to the vesting of restricted shares granted under a share incentive plan
                or pursuant to a contractual employment arrangement described in the Prospectus;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zee82c049cc7d4ab78fe9c6203e687a6a" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Ordinary Shares acquired in the Offering or in open market transactions after the Offering, provided that no public disclosures or filing reporting a reduction in beneficial ownership of shares of Ordinary Shares shall be required, or
                made voluntarily, in connection with subsequent sales of such securities;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z65c19504f03d4ddaacfa33a85325bbbf" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares to any corporation, partnership, limited liability company or other entity all of the beneficial ownership interests of which are held by the undersigned or its affiliates, provided that (i) the transferee
                agrees to be bound in writing by the restrictions set forth herein, (ii) any such transfer shall not involve a disposition for value and (iii) no public disclosures or filing reporting a reduction in beneficial ownership of Ordinary Shares
                shall be required, or made voluntarily;</div>
            </td>
          </tr>

      </table>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-2</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7932050ab839467a8fd64e91cfea7a63" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares as part of a distribution, transfer or disposition by the undersigned to its limited or general partners, members, stockholders or affiliates (as defined under Rule 12b-2 of the Exchange Act), provided that
                (i) the transferee agrees to be bound in writing by the restrictions set forth herein, (ii) any such transfer shall not involve a disposition for value and (iii) no public disclosures or filing reporting a reduction in beneficial ownership
                of Ordinary Shares shall be required, or made voluntarily;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zeaff57cd460845b78ff09723ee60c834" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares by operation of law, including pursuant to orders of a court or regulatory agency, a domestic order or negotiated divorce settlement;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z43555ae8ae5f4442b9889b7d9d191af3" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a transfer of Ordinary Shares pursuant to any contractual arrangement described in the Prospectus in effect on the date of this letter agreement that provides for the repurchase of the undersigned&#8217;s Ordinary Shares by the Company in
                connection with the termination of the undersigned&#8217;s employment or other service relationship with the Company or the undersigned&#8217;s failure to meet certain conditions set out upon receipt of such Ordinary Shares, or</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze759c25f9e2e4b2faa1b9895bc7b98f7" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>a bona fide third-party tender offer for all outstanding shares of the Company, merger, consolidation or other similar transaction made to all holders of the Company&#8217;s securities involving a change of control of the Company (including,
                without limitation, the entering into any lock-up, voting or similar agreement pursuant to which the undersigned may agree to transfer, sell, tender or otherwise dispose of Ordinary Shares or other such securities in connection with such
                transaction, or vote any Ordinary Shares or other such securities in favor of any such transaction), provided that in the event that such tender offer, merger, consolidation or other such transaction is not completed, such securities held
                by the undersigned shall remain subject to the provisions of this letter agreement.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>Furthermore, nothing in this letter agreement shall be deemed to prevent the undersigned from establishing any contract, instruction or plan (a &#8220;<font style="font-weight: bold;">Plan</font>&#8221;) pursuant to Rule 10b5-1 under the Exchange Act for
        the transfer of Ordinary Shares, provided that (a) such Plan does not provide for the transfer of Ordinary Shares during the Lock-Up Period and (b) no public filing or disclosure of any such action shall be required or voluntarily made by any
        person during the Lock-Up Period.</div>
      <div><br>
      </div>
      <div>The undersigned also agrees and consents to the entry of stop transfer instructions with the Company&#8217;s transfer agent and registrar against the transfer of Ordinary Shares and/or Related Securities held by the undersigned and the undersigned&#8217;s
        Family Members, if any, except in compliance with the foregoing restrictions.</div>
      <div><br>
      </div>
      <div>The undersigned confirms that the undersigned has not, and has no knowledge that any Family Member has, directly or indirectly, taken any action designed to or that might reasonably be expected to cause or result in the stabilization or
        manipulation of the price of any security of the Company to facilitate the sale of the Ordinary Shares.&#160; The undersigned will not, and will cause any Family Member not to take, directly or indirectly, any such action.</div>
      <div><br>
      </div>
      <div>Whether or not the Offering occurs as currently contemplated or at all depends on market conditions and other factors.&#160; The Offering will only be made pursuant to the Underwriting Agreement, the terms of which are subject to negotiation between
        the Company and the underwriters.</div>
      <div><br>
      </div>
      <div>The undersigned hereby represents and warrants that the undersigned has full power, capacity and authority to enter into this letter agreement.&#160; This letter agreement is irrevocable and will be binding on the undersigned and the successors,
        heirs, personal representatives and assigns of the undersigned.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-3</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div>This letter agreement shall be governed by, and construed in accordance with, the laws of the State of New York.</div>
      <div><br>
      </div>
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          <tr>
            <td style="width: 50%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;"><br>
              </div>
            </td>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Signature</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Printed Name of Person Signing</div>
            </td>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
          </tr>

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        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-4</font></div>
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      <div><br>
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      <div style="text-align: center; font-weight: bold;">Certain Defined Terms</div>
      <div style="text-align: center; font-weight: bold;"><u>Used in Lock-up Agreement</u></div>
      <div><br>
      </div>
      <div>For purposes of the letter agreement to which this Annex A is attached and of which it is made a part:</div>
      <div><br>
      </div>
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          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Call Equivalent Position</font>&#8221;<font style="font-weight: bold;">&#160;</font>shall have the meaning set forth in Rule 16a-1(b) under the Exchange Act.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
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          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Exchange Act</font>&#8221;<font style="font-weight: bold;">&#160;</font>shall mean the Securities Exchange Act of 1934, as amended.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf5e85c6c5cc147ca8698578a6b1887a8" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Family Member</font>&#8221; shall mean the spouse of the undersigned, an immediate family member of the undersigned or an immediate family member of the undersigned&#8217;s spouse, in each case living in the
                undersigned&#8217;s household or whose principal residence is the undersigned&#8217;s household (regardless of whether such spouse or family member may at the time be living elsewhere due to educational activities, health care treatment, military
                service, temporary internship or employment or otherwise).&#160; &#8220;<font style="font-weight: bold;">Immediate family member</font>&#8221; as used above shall have the meaning set forth in Rule 16a-1(e) under the Exchange Act.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0798e42faec74472aa52b0750b78d0cf" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Lock-up Period</font>&#8221; shall mean the period beginning on the date hereof and continuing through the close of trading on the date that is 90 days after the date of the Prospectus (as defined in the
                Underwriting Agreement).</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc4cd1be9f7d4439bbe43acc370e9f1c3" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Put Equivalent Position</font>&#8221; shall have the meaning set forth in Rule 16a-1(h) under the Exchange Act.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4b9ce112b868478bb13964d96b008dbd" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Related Securities</font>&#8221; shall mean any options or warrants or other rights to acquire ADSs or Ordinary Shares or any securities exchangeable or exercisable for or convertible into ADSs or Ordinary
                Shares, or to acquire other securities or rights ultimately exchangeable or exercisable for or convertible into ADSs or Ordinary Shares.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z1fbcf5c550064fa39a0595cd3d082813" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Securities Act</font>&#8221; shall mean the Securities Act of 1933, as amended.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z44346666538f4462bafe446424c8c71e" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Sell or Offer to Sell</font>&#8221; shall mean to:</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb623520ff997487ea80f2add3f248a8c" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8722;</td>
            <td style="width: auto; vertical-align: top;">
              <div>sell, offer to sell, contract to sell or lend,</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7f281e967b7e4de5bfe43e0284df679e" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8722;</td>
            <td style="width: auto; vertical-align: top;">
              <div>effect any short sale or establish or increase a Put Equivalent Position or liquidate or decrease any Call Equivalent Position</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0042266799b248449091bb2f6c9fc16f" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8722;</td>
            <td style="width: auto; vertical-align: top;">
              <div>pledge, hypothecate or grant any security interest in, or</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z956e3ce5d9c74a7b83c58e64d478a453" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8722;</td>
            <td style="width: auto; vertical-align: top;">
              <div>in any other way transfer or dispose of,</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-indent: 36pt;">in each case whether effected directly or indirectly.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd32794c6230544fb925e33e5fef14d81" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>&#8220;<font style="font-weight: bold;">Swap</font>&#8221; shall mean any swap, hedge or similar arrangement or agreement that transfers, in whole or in part, the economic risk of ownership of ADSs, Ordinary Shares or Related Securities, regardless
                of whether any such transaction is to be settled in securities, in cash or otherwise.</div>
            </td>
          </tr>

      </table>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-1</font></div>
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif; font-weight: normal;">Capitalized terms not defined in this Annex A shall have the meanings given to them in the body of this letter agreement.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">F-2</font></div>
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          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div style="text-align: right; font-weight: bold;">Exhibit G</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Certain Shareholders, Directors and Executive Officers</div>
      <div style="text-align: center; font-weight: bold;"><u>Signing Lock-up Agreement</u></div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdae25c17d44f416f9b037c84a3cb80c8" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Ever Regal Group Limited</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6333e6e0e8594e2c930498aea4d85abc" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Fairy Eagle Investment Limited</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z96eec7f69ee54370b070737c9dc43dc7" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Rosy Time Holdings Limited</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4717df526e634dffa9825098ea1c7cad" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Decheng Capital China Life Sciences USD Fund II, L.P.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zda4d787603924342ae827f6f51a6c3e6" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Decheng Capital China Life Sciences USD Fund III, L.P.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8c38d26d227e4141aee33b7030b15afb" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Lan Huang, Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2041d9caaa894848832f6507de4e650f" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Elizabeth Czerepak, M.B.A.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z235ec5774a464f12b5f81d028ac96bdf" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Edward Dongheng Liu</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z03d6be3efd0c43fa8657d9520c29bcd1" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Ramon W. Mohanlal, M.D., Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z61b805d6e830409790eb682167d16340" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>G. Kenneth Lloyd, Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb8b251e1b82b4c7ebc615e0b4d4eec3f" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Gordon L. Schooley, Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6157fc6d99814e0e9556dd1402539f98" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Richard Daly, M.B.A.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4fc2f4211fa048be930502249a74143e" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>James R. Tonra, Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z56ba13ec8df8450a9757f12950ca4842" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Patrick Fabbio, M.B.A.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdc67703551bf4a89ba83eaebeb89f03b" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Matthew Kirkby, M.A.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z439d6531e08148d88ba7cdfc6f65c129" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Quanqi Song, Ph.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z646e37171aee4512a2eba2cf25e36055" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Yanbin Xie, M.D.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze70ac2ba0ebb49adac01fb569b461648" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Christine Ying Zhao, M.B.A.</div>
            </td>
          </tr>

      </table>
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            <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
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              <div>Daniel L. Zabrowski, Ph.D.</div>
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      <div style="text-indent: 18pt; text-align: center;">G-1<br>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>nt10017010x4_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">Exhibit 5.1</div>
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          <td style="width: 90pt; vertical-align: top; align: right;">Our ref</td>
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            <div>VSL/715660-000001/18661735v2</div>
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    <div>BeyondSpring Inc.</div>
    <div>28 Liberty Street, 39th Floor</div>
    <div>New York, New York 10005</div>
    <div><br>
    </div>
    <div style="text-align: justify;">23 November 2020</div>
    <div><br>
    </div>
    <div style="text-align: justify;">Dear Sirs,</div>
    <div><br>
    </div>
    <div style="color: #000000; font-weight: bold;">BeyondSpring Inc.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">We have acted as Cayman Islands legal advisers to BeyondSpring Inc. (the "<font style="font-weight: bold;">Company</font>") in connection with the Company&#8217;s registration statement on Form F-3, including all amendments
      or supplements thereto, filed with the Securities and Exchange Commission (the '"<font style="font-weight: bold;">SEC</font>") under the U.S. Securities Act of 1933 on 3 November 2020 and declared effective by the SEC on 12 November 2020, as amended
      to date (the "<font style="font-weight: bold;">Registration Statement</font>") relating to the offering by the Company of certain ordinary shares of par value US$0.0001 each (the "<font style="font-weight: bold;">Shares</font>").</div>
    <div><br>
    </div>
    <div style="text-align: justify;">We are furnishing this opinion as Exhibits 5.1 and 23.1 to the Registration Statement.</div>
    <div><br>
    </div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-weight: bold;">1</td>
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            <div style="font-weight: bold;">Documents Reviewed</div>
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    <div style="text-align: justify;">For the purposes of this opinion, we have reviewed only originals, copies or final drafts of the following documents:</div>
    <div><br>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.1</td>
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            <div>The certificate of incorporation of the Company dated 21 November 2014.</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.2</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The amended and restated memorandum and articles of association of the Company as conditionally adopted by a special resolution passed on 24 February 2017 and effective immediately prior to the completion of the Company&#8217;s initial public
              offering of the Shares (the "<font style="font-weight: bold;">Memorandum and Articles</font>").</div>
          </td>
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    <div><br>
    </div>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.3</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The written resolutions of the board of directors of the Company dated 1 November 2020 (the "<font style="font-weight: bold;">Directors'</font>&#160;<font style="font-weight: bold;">Resolutions</font>").</div>
          </td>
        </tr>

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          <td style="width: 36pt; vertical-align: top; align: right;">1.4</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The written resolutions of the offering committee of the board of directors of the Company dated 17 November 2020 and 18 November 2020 (the "<font style="font-weight: bold;">Committee Resolutions</font>").</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.5</td>
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            <div>A certificate from a director of the Company, a copy of which is attached hereto (the "<font style="font-weight: bold;">Director's Certificate</font>").</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.6</td>
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            <div>A certificate of good standing dated 18 November 2020, issued by the Registrar of Companies in the Cayman Islands (the "<font style="font-weight: bold;">Certificate of Good Standing</font>").</div>
          </td>
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          <td style="width: 36pt; vertical-align: top; align: right;">1.7</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The Registration Statement.</div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-weight: bold;">2</td>
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            <div style="font-weight: bold;">Assumptions</div>
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    <div style="text-align: justify;">The following opinions are given only as to, and based on, circumstances and matters of fact existing and known to us on the date of this opinion letter.&#160; These opinions only relate to the laws of the Cayman Islands
      which are in force on the date of this opinion letter.&#160; In giving these opinions we have relied (without further verification) upon the completeness and accuracy of the Director's Certificate and the Certificate of Good Standing.&#160; We have also relied
      upon the following assumptions, which we have not independently verified:</div>
    <div><br>
    </div>
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          <td style="width: 36pt; vertical-align: top; align: right;">2.1</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>Copies of documents, conformed copies or drafts of documents provided to us are true and complete copies of, or in the final forms of, the originals, and translations of documents provided to us are complete and accurate.</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">2.2</td>
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            <div>All signatures, initials and seals are genuine.</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">2.3</td>
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            <div>There is nothing under any law (other than the law of the Cayman Islands), and there is nothing contained in the minute book or corporate records of the Company (which we have not inspected), which would or might affect the opinions set
              out below.</div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-weight: bold;">3</td>
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            <div style="font-weight: bold;">Opinion</div>
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    <div>Based upon the foregoing and subject to the qualifications set out below and having regard to such legal considerations as we deem relevant, we are of the opinion that:</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">3.1</td>
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            <div>The Company has been duly incorporated as an exempted company with limited liability and is validly existing and in good standing under the laws of the Cayman Islands.</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">3.2</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The authorised share capital of the Company is US$50,000 divided into 500,000,000 ordinary shares of a par value of US$0.0001 each.</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">3.3</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>The issue and allotment of the Shares have been duly authorised and when allotted, issued and paid for as contemplated in the Registration Statement, the Shares will be legally issued and allotted, fully paid and non-assessable. As a
              matter of Cayman law, a share is only issued when it has been entered in the register of members (shareholders).</div>
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    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">2</font></div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-weight: bold;">4</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Qualifications</div>
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    <div style="text-align: justify;">In this opinion the phrase "non-assessable" means, with respect to shares in the Company, that a shareholder shall not, solely by virtue of its status as a shareholder and in absence of a contractual arrangement, or an
      obligation pursuant to the memorandum and articles of association, to the contrary, be liable for additional assessments or calls on the shares by the Company or its creditors (except in exceptional circumstances, such as involving fraud, the
      establishment of an agency relationship or an illegal or improper purpose or other circumstances in which a court may be prepared to pierce or lift the corporate veil).</div>
    <div><br>
    </div>
    <div style="text-align: justify;">Except as specifically stated herein, we make no comment with respect to any representations and warranties which may be made by or with respect to the Company in any of the documents or instruments cited in this
      opinion or otherwise with respect to the commercial terms of the transactions the subject of this opinion.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and to the reference to our name under the headings "Enforceability of Civil Liabilities" and "Legal Matters" and elsewhere in
      the prospectus included in the Registration Statement.&#160; In giving such consent, we do not thereby admit that we come within the category of persons whose consent is required under Section 7 of the U.S. Securities Act of 1933, as amended, or the Rules
      and Regulations of the Commission thereunder.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">Yours faithfully</div>
    <div><br>
    </div>
    <div style="text-align: justify;"><u>/s/ Maples and Calder (Hong Kong) LLP</u></div>
    <div><br>
    </div>
    <div style="text-align: justify;">Maples and Calder (Hong Kong) LLP</div>
    <div style="text-align: justify;">Encl</div>
    <div style="text-align: justify;"> <br>
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