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Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total $ (20,143) $ (15,184) $ (57,480) $ (45,445)  
Retained Earnings (Accumulated Deficit), Ending Balance (332,484)   (332,484)   $ (277,818)
Net Cash Provided by (Used in) Operating Activities, Total     (30,324) $ (36,783)  
Net Current Assets 76,111   76,111    
Cash, Cash Equivalents, and Short-term Investments, Total 91,600   91,600    
Debt Securities, Trading, Unrealized Gain 105   105    
Debt Securities, Available-for-sale, Amortized Cost, Total 1,645   1,645    
Debt Securities, Available-for-sale, Allowance for Credit Loss, Ending Balance 0   0    
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Total     0    
Contract with Customer, Asset, after Allowance for Credit Loss, Total 0   0    
Long-term Debt, Excluding Current Maturities, Total $ 0   0   2,167
Long-term Debt, Fair Value         $ 2,136
Product [Member]          
Revenue from Contract with Customer, Excluding Assessed Tax, Total     $ 0