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Note 10 - Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]

		Number of shares				Weighted average grant date fair value
							$
Outstanding at December 31, 2018			155,250				19.94
Granted			112,427				14.11
Vested			(113,102	)			17.90
Forfeited			-				-
Outstanding at December 31, 2019			154,575				17.19
Granted			14,394				12.82
Vested			(38,023	)			15.19
Forfeited			-				-
Outstanding at December 31, 2020			130,946				17.30
Granted			15,164				14.64
Vested			(22,683	)			14.78
Forfeited			(40,679	)			14.00
Outstanding at December 31, 2021			82,748				19.12
Expected to vest at December 31, 2021			7,748				12.52

Share-based Payment Arrangement, Option, Activity [Table Text Block]

		Number of options				Weighted average exercise price				Weighted average grant date fair value				Weighted average remaining contractual term				Aggregate intrinsic value
							$				$			Years					$
Outstanding at December 31, 2018			465,900				27.91								9.12
Granted			19,700				13.96				8.63
Canceled			(335,900	)			29.00				19.91
Outstanding at December 31, 2019			149,700				23.61								8.69
Granted			1,791,943				13.32				8.21
Forfeited			(2,594	)			13.83				8.64
Outstanding at December 31, 2020			1,939,049				14.12								9.38
Granted			1,134,672				11.24				8.19
Exercised			(98,500	)			16.13				9.66								473
Forfeited			(307,883	)			14.52				9.06
Outstanding at December 31, 2021			2,667,338				12.77								8.82				-
Exercisable as of December 31,2021			871,881				14.58								8.41				-
Vested and expected to vest at December 31, 2021			1,777,271				13.51								8.73				-

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		December 31,
		2019					2020					2021
Fair value of ordinary share				13.96			10.37	~	17.94			9.48	~	31.31
Risk-free interest rate		1.62%	~	1.68%			0.11%	~	1.64%			0.37%	~	1.47%
Expected term (years)		5.0	~	7.1			5.0	~	10.0			5.0	~	7.49
Expected volatility				70%			70%	~	75%			75%	~	90%
Expected dividend yield				0%					0%					0%
Contractual life (years)				10					10					10

		December 31, 2021
Exercise price			10.18
Fair value of ordinary share			10.71
Risk-free interest rate			1.63	%
Contractual term (years)			10
Expected volatility			75	%
Expected dividend yield			0	%

Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Year Ended December 31,
		2019				2020				2021
			$				$				$
Research and development			630				4,124				901
General and administrative			1,471				4,070				2,251
Total			2,101				8,194				3,152

X

- Definition

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