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Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total $ (68,208) $ (63,821) $ (40,333)
Retained Earnings (Accumulated Deficit), Ending Balance (341,997) (277,818)  
Net Cash Provided by (Used in) Operating Activities, Total (47,242) (43,745) (48,162)
Net Current Assets 59,968    
Cash, Cash Equivalents, and Short-term Investments, Total 72,368    
Debt Securities, Available-for-sale, Allowance for Credit Loss, Ending Balance 0    
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Total 0    
Accounts Receivable, Allowance for Credit Loss, Ending Balance 0 0  
Impairment of Long-Lived Assets to be Disposed of 0 0 0
Long-term Debt, Total   2,167  
Long-term Debt, Fair Value   2,136  
Revenue from Contract with Customer, Including Assessed Tax $ 1,351 $ 180 $ 0
Depreciation of RMB Against U.S. Dollar, Percent 2.30% 6.30% 1.30%